Results 121 to 130 of about 6,518 (266)

Resolved Stellar Populations of Super-Metal-Rich Star Clusters in the\n Bulge of M31 [PDF]

, 2000
P. Jablonka, F. Courbin, G. Meylan, A. Sarajedini, Terry Bridges, Pierre Magain   +5 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Novel Approach to Identifying Substructures through Analysis of Metallicity Distribution Functions

The Astrophysical Journal
We present a new method for identifying Galactic halo substructures accreted from dwarf galaxies by combining metallicity distribution functions (MDFs) with orbital parameters.
Young Kwang Kim, Young Sun Lee, Timothy C. Beers   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Observational Properties of Primordial Stellar Populations [PDF]

, 2002
N. Panagia, M. Stiavelli, Henry C. Ferguson, H. S. Stockman   +3 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

STELLAR POPULATIONS OF Lyα EMITTERS ATz∼ 6-7: CONSTRAINTS ON THE ESCAPE FRACTION OF IONIZING PHOTONS FROM GALAXY BUILDING BLOCKS [PDF]

, 2010
Yoshiaki Ono, Kazuhiro Shimasaku, J. C. Dunlop, D. Farrah, Ross McLure, Sadanori Okamura   +5 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

oMEGACat. VIII. A Subpopulation Census of ω Centauri

The Astrophysical Journal
An understanding of the assembly history of the complex star cluster Omega Centauri has long been sought after, with many studies separating the stars on the color–magnitude diagram into multiple groupings across small magnitude ranges.
C. Clontz, A. C. Seth, Z. Wang, M. Häberle, M. S. Nitschai, N. Neumayer, P. J. Smith, M. Latour, A. Feldmeier-Krause, M. Libralato, A. Bellini   +10 more
doaj   +1 more source

Spatially-resolved stellar populations of nearby galaxies in multi-filter surveys [PDF]

, 2016
I. San Roman, A. J. Cenarro, L. A. Díaz-García, C. López-Sanjuán, J. Varela, the J-PLUS Team   +5 more
openalex   +1 more source