Results 111 to 120 of about 1,811,299 (294)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Characterizing Supernova Host Galaxies with FrankenBlast: A Scalable Tool for Transient Host Galaxy Association, Photometry, and Stellar Population Modeling

The Astrophysical Journal
We present FrankenBlast , a customized and improved version of the Blast web application. FrankenBlast associates transients to their host galaxies, performs host photometry, and runs a innovative spectral energy distribution fitting code to constrain ...
Anya E. Nugent, V. Ashley Villar, Alex Gagliano, David O. Jones, Asaf Horowicz, Kaylee de Soto, Bingjie Wang, Ben Margalit   +7 more
doaj   +1 more source

CHRONOS: Towards a self-consistent and absolute stellar age scale

Astronomy & Astrophysics
Context. Establishing a self-consistent age scale for stellar populations requires physically well-calibrated chronometers. Among these, lithium-based diagnostics, particularly the lithium depletion boundary (LDB), provide one of the most robust age ...
González-Ramírez L., Barrado D., Olivares J., Berihuete A., Sarro L. M., Palmero F. J.   +5 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Dissecting stellar populations with manifold learning

Context. Different stellar populations may be identified through differences in chemical, kinematic, and chronological properties, suggesting the interplay of various physical mechanisms that led to their origin and subsequent evolution.
A. Miglio, A. W. Neitzel, D. Bossini, T. L. Campante   +3 more
core   +1 more source

New Rotation Periods from the Kepler Bonus Background Light Curves

The Astrophysical Journal
The Kepler field hosts the best-studied sample of field star rotation periods. However, due to Kepler’s large 4″ pixels, many of its light curves are at high risk of contamination from background sources.
Zachary R. Claytor, Jamie Tayar
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Azimuthal Misalignments in Stellar Warp Structure as Dynamical Tracers of Mergers in Milky Way–like Galaxies

The Astrophysical Journal Letters
We investigate the origin of warps in stellar disks using high-resolution Milky Way analogs from the IllustrisTNG50 simulation. Focusing on galaxies that experienced a major merger, we identify a characteristic azimuthal misalignment between the warp ...
Lekshmi Thulasidharan, Elena D’Onghia, Robert Benjamin   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Modeling Small Stellar Populations Using Starburst99

, 2015
In this work, we have developed a new approach to form stars from clusters first, where massive stars are formed from fractions of mass of small stellar clusters.
Gerardo A. Vázquez, Claus Leitherer
core   +1 more source