Results 101 to 110 of about 1,883,435 (259)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

New Rotation Periods from the Kepler Bonus Background Light Curves

The Astrophysical Journal
The Kepler field hosts the best-studied sample of field star rotation periods. However, due to Kepler’s large 4″ pixels, many of its light curves are at high risk of contamination from background sources.
Zachary R. Claytor, Jamie Tayar
doaj   +1 more source

CHRONOS: Towards a self-consistent and absolute stellar age scale

Astronomy & Astrophysics
Context. Establishing a self-consistent age scale for stellar populations requires physically well-calibrated chronometers. Among these, lithium-based diagnostics, particularly the lithium depletion boundary (LDB), provide one of the most robust age ...
González-Ramírez L., Barrado D., Olivares J., Berihuete A., Sarro L. M., Palmero F. J.   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Chemical Radial Gradients for the Bulge Bar Stellar Populations from the APOGEE Survey

The Astrophysical Journal
The Milky Way bulge bar is composed of multiple populations. Using chemical and kinematical planes, we segregate six populations in a bulge bar sample observed by the APOGEE survey: two with bar-driven orbits, two with eccentric orbits, and two with low ...
J. V. Sales-Silva, K. Cunha, V. V. Smith, S. Daflon, D. Souto, R. Guerço, V. Loaiza-Tacuri, A. Queiroz, C. Chiappini, I. Minchev, S. R. Majewski, B. Barbuy, D. Bizyaev, José G. Fernández-Trincado, Peter M. Frinchaboy, S. Hasselquist, D. Horta, Henrik Jönsson, T. Masseron, N. Prantzos, R. P. Schiavon, M. Schultheis, M. Zoccali   +22 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Stellar flares cannot explain the Galactic 511 keV emission

Astronomy & Astrophysics
Context. The origin of the 511 keV line signal in the Milky Way remains unresolved despite decades of observations. The measured flux of ∼3 × 10−3 ph cm−2 s−1 suggests a steady-state positron injection rate of ∼1043-1044 e+ s−1.
Mittal Saurabh, Siegert Thomas, Calore Francesca, Panther Fiona H., Serpico Pasquale D., Yoneda Hiroki, Bauer Niklas C., Bouchet Tristan, Eisenberger Laura, Gelowicz Mika A., Oka Tomohiko, Reinhardt Rudi, Skalka Manuel R. H. W., Tsatsis Dimitris, Zimmerer Manja L.   +14 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Azimuthal Misalignments in Stellar Warp Structure as Dynamical Tracers of Mergers in Milky Way–like Galaxies

The Astrophysical Journal Letters
We investigate the origin of warps in stellar disks using high-resolution Milky Way analogs from the IllustrisTNG50 simulation. Focusing on galaxies that experienced a major merger, we identify a characteristic azimuthal misalignment between the warp ...
Lekshmi Thulasidharan, Elena D’Onghia, Robert Benjamin   +2 more
doaj   +1 more source

Planetary nebulae as tracers of accreted stellar populations in massive galaxies in groups and clusters

Frontiers in Astronomy and Space Sciences
Planetary nebulae (PNe) are valuable spatial and kinematic tracers of nearby galaxies. In this mini-review, I focus on their role in tracing the halo and intra-cluster/intra-group light assembly in groups and clusters of galaxies within 100 Mpc and, in ...
Johanna Hartke, Johanna Hartke, Johanna Hartke   +2 more
doaj   +1 more source