Results 101 to 110 of about 104,545 (289)

PANCAKE: A Python-based Numerical Color–Magnitude Diagram Analysis Package

open access: yesThe Astrophysical Journal Supplement Series
Stellar populations serve as a fossil record of galaxy formation and evolution, providing crucial information about the history of star formation and galaxy evolution.
Yun Zheng   +13 more
doaj   +1 more source

Bridging Model and Observed Stellar Spectra

open access: yes, 2010
Accurate model stellar fluxes are key for the analysis of observations of individual stars or stellar populations. Model spectra differ from real stellar spectra due to limitations of the input physical data and adopted simplifications, but can be ...
Allende Prieto   +33 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Fluorine Abundances in Local Stellar Populations

open access: yesThe Astronomical Journal
We present the first fluorine measurements in 12 normal K giants belonging to the Galactic thin and thick disks using spectra obtained with the Phoenix infrared spectrometer on the 2.1 m telescope at Kitt Peak. Abundances are determined from the (1−0) R9
K. E. Brady   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Azimuthal Misalignments in Stellar Warp Structure as Dynamical Tracers of Mergers in Milky Way–like Galaxies

open access: yesThe Astrophysical Journal Letters
We investigate the origin of warps in stellar disks using high-resolution Milky Way analogs from the IllustrisTNG50 simulation. Focusing on galaxies that experienced a major merger, we identify a characteristic azimuthal misalignment between the warp ...
Lekshmi Thulasidharan   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

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