Results 121 to 130 of about 15,741 (301)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Stellar populations in gravitationally bound systems [PDF]

open access: yes, 2020
The understanding of how, which, where and when stars form provides important information for the vast majority of astronomical fields. Star-formation has a complex multi-scale physical nature. Stars form in dense sub-parsec regions of molecular clouds,
Jeřábková, Tereza
core  

New Rotation Periods from the Kepler Bonus Background Light Curves

open access: yesThe Astrophysical Journal
The Kepler field hosts the best-studied sample of field star rotation periods. However, due to Kepler’s large 4″ pixels, many of its light curves are at high risk of contamination from background sources.
Zachary R. Claytor, Jamie Tayar
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

On Stellar Models with Blanketed Atmospheres as Boundary Conditions

open access: yes, 2007
The impact on the predicted Teff scale of using the latest MARCS model atmospheres, instead of a fixed atmospheric structure (e.g., the gray T–τ relation) is examined.
Edvardsson, Bengt,   +4 more
core   +1 more source

Chemical Radial Gradients for the Bulge Bar Stellar Populations from the APOGEE Survey

open access: yesThe Astrophysical Journal
The Milky Way bulge bar is composed of multiple populations. Using chemical and kinematical planes, we segregate six populations in a bulge bar sample observed by the APOGEE survey: two with bar-driven orbits, two with eccentric orbits, and two with low ...
J. V. Sales-Silva   +22 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Evolutionary synthesis of simple stellar populations

open access: yes, 1998
. We construct evolutionary synthesis models for simple stellar populations using the evolutionary tracks from the Padova group (1993, 1994), theoretical colour calibrations from Lejeune et al.
O. M. Kurth   +6 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Stellar populations in bulges. The isolated galaxies. [PDF]

open access: yes, 2019
In a recent series of papers we presented the results of the investigation on the stellar populations and their gradients of the bulge dominated region.
Morelli, L.   +6 more
core  

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