Results 121 to 130 of about 104,545 (289)
Primordial Stellar Populations
, 2002 We review the expected properties of the first stellar generations in the Universe. In particular, we consider and discuss the diagnostics, based on the emission from associated HII regions, that permit one to discern bona fide primeval stellar generations from the ones formed after pollution by supernova explosions has occurred. We argue that a proper
openaire +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Stellar Population Properties in the Stellar Streams around SPRC047
The Astrophysical JournalAbstract We have investigated the properties (e.g., age, metallicity) of the stellar populations of a ringlike tidal stellar stream (or streams) around the edge-on galaxy SPRC047 (z = 0.031) using spectral energy distribution (SED) fits to integrated broadband aperture flux densities.
Seppo Laine +7 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The competing influences of ram pressure and tidal interaction in NGC 2276
Astronomy & AstrophysicsContext. The evolution of galaxies in groups is profoundly influenced by a variety of physical processes, with ram pressure and tidal interactions playing pivotal roles in shaping their structural and evolutionary pathways.
Matijević L. +11 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
TESS Stellar Rotation up to 80 Days in the Southern Continuous Viewing Zone
The Astrophysical JournalThe Transiting Exoplanet Survey Satellite (TESS) mission delivers time-series photometry for millions of stars across the sky, offering a probe into stellar astrophysics, including rotation, on a population scale. However, light-curve systematics related
Zachary R. Claytor +5 more
doaj +1 more source
, 1996 Monte-Carlo simulations of optical and near-infrared colour-magnitude diagrams in Baade's Window (l=1.0,b=-3.9) are compared with each other. The morphological structure of the red horizontal branch in those CMDs is likely due to a combination of extinction and age-metallicity of the stars from the bulge/bar.
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source