Results 141 to 150 of about 104,545 (289)

oMEGACat. IV. Constraining the Ages of Omega Centauri Subgiant Branch Stars with HST and MUSE

The Astrophysical Journal
We present age estimates for over 8100 subgiant branch (SGB) stars in Omega Centauri ( ω Cen) to study its star formation history. Our large data set, which combines multi-wavelength Hubble Space Telescope photometry with MUSE metallicities, provides an ...
C. Clontz, A. C. Seth, A. Dotter, M. Häberle, M. S. Nitschai, N. Neumayer, A. Feldmeier-Krause, M. Latour, Z. Wang, S. O. Souza, N. Kacharov, A. Bellini, M. Libralato, R. Pechetti, G. van de Ven, M. Alfaro-Cuello   +15 more
doaj   +1 more source

The stellar to sub-stellar masses transition in 47 Tuc

Astronomy & Astrophysics
Context. The study of the globular cluster 47 Tuc offers an opportunity to shed new light on the debated issue of the presence of multiple populations in globular clusters, as recent results from HST photometry and high-resolution spectroscopy outlined ...
Ventura C., Tailo M., Ventura P., D’Antona F., Milone A. P., Marino A. F., Fiumi C.   +6 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

On the Origin of Neutron-capture Elements in r-I and r-II Stars: A Differential-abundance Analysis

The Astrophysical Journal
We present a strictly line-by-line differential analysis of a moderately r -process-enhanced star ( r -I: HD 107752) with respect to a strongly r -process-enhanced star ( r -II: CS 31082-0001) to investigate the possible common origin of their heavy ...
Pallavi Saraf, Thirupathi Sivarani, Timothy C. Beers, Yutaka Hirai, Masaomi Tanaka, Carlos Allende Prieto, Drisya Karinkuzhi   +6 more
doaj   +1 more source

Implications for the formation of Oort cloud-like structures and interstellar comets in dense environments

Astronomy & Astrophysics
Most stars form in dense stellar environments, where frequent close encounters can strongly perturb and reshape the early architecture of planetary systems.
Torres Santiago
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Extended Stellar Populations in Ultrafaint Dwarf Galaxies

The Astronomical Journal
The possible existence of stellar halos in low-mass galaxies is being intensely discussed nowadays after some recent discoveries of stars located in the outskirts of dwarf galaxies of the Local Group.
Elisa A. Tau, A. Katherina Vivas, Clara E. Martínez-Vázquez   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hidden Figures of Globular Clusters: Integrated Stellar Populations Impacted by Hot Subdwarfs

The Astrophysical Journal
Globular clusters (GCs) are fundamental for understanding the integrated light of old stellar populations and galaxy assembly processes. However, the role of hot, evolved stars, such as horizontal branch (HB), extreme HB, and blue stragglers, remains ...
Thayse A. Pacheco, Paula R. T. Coelho, Lucimara P. Martins, Ricardo P. Schiavon, Erik V. R. de Lima, Marcos P. Diaz, Domenico Nardiello, Ronaldo S. Levenhagen, Rogério Riffel, Charles J. Bonatto, Ana L. Chies-Santos   +10 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source