Results 141 to 150 of about 15,741 (301)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The distribution of stellar populations within galaxies

, 2014
The study of stellar populations in galaxies is particularly interesting, since they are a fossil record of several physical processes associated with the formation and evolution of galaxies.
Novais, Patricia Martins de, Junior, Laerte Sodre   +1 more
core  

Stellar populations in the SAMI Galaxy Survey

We present a set of line index-based measurements of the relative α-element abundance, [α/Fe], for up to 2097 galaxies in the Sydney-Australian-Astronomical-Observatory Multi-object Integral-field Spectrograph (SAMI) Galaxy Survey using aperture spectra ...
Watson, Peter Jonathan
core   +1 more source

GALAXY STRUCTURE, STELLAR POPULATIONS, AND STAR FORMATION QUENCHING AT 0.6 ≲ <i>z</i> ≲ 1.2. [PDF]

Astrophys J, 2018
Kim K, Malhotra S, Rhoads JE, Joshi B, Fererras I, Pasquali A.   +5 more
europepmc   +1 more source

oMEGACat. VIII. A Subpopulation Census of ω Centauri

The Astrophysical Journal
An understanding of the assembly history of the complex star cluster Omega Centauri has long been sought after, with many studies separating the stars on the color–magnitude diagram into multiple groupings across small magnitude ranges.
C. Clontz, A. C. Seth, Z. Wang, M. Häberle, M. S. Nitschai, N. Neumayer, P. J. Smith, M. Latour, A. Feldmeier-Krause, M. Libralato, A. Bellini   +10 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Extended Stellar Populations in Ultrafaint Dwarf Galaxies

The Astronomical Journal
The possible existence of stellar halos in low-mass galaxies is being intensely discussed nowadays after some recent discoveries of stars located in the outskirts of dwarf galaxies of the Local Group.
Elisa A. Tau, A. Katherina Vivas, Clara E. Martínez-Vázquez   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Stellar populations in the Galactic bulge

, 2009
AIMS:The aim of this paper is to study the characteristics of the stellar populations and the metallicity distribution in the Galactic bulge. We study the entire stellar population, but also retrieve information using only the red clump stars.
M. A. T. Groenewegen, L. Girardi, Girardi, L., E. Vanhollebeke, Vanhollebeke, E., Groenewegen, M. A. T.   +5 more
core   +1 more source