Results 141 to 150 of about 1,811,299 (294)

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Final report on the STELLAR Delphi study: Future directions for TEL and TEL research: areas of tension, core research areas and grand challenge problems

, 2012
In this report on the STELLAR Delphi study, we present the results of the final global survey, that is the 4th STELLAR Delphi round, and illustrate the elaboration and dissemination of these results (5th STELLAR Delphi round).
Spada, Hans, Plesch, Christine, Wiedmann, Michael   +2 more
core   +2 more sources

oMEGACat. VIII. A Subpopulation Census of ω Centauri

The Astrophysical Journal
An understanding of the assembly history of the complex star cluster Omega Centauri has long been sought after, with many studies separating the stars on the color–magnitude diagram into multiple groupings across small magnitude ranges.
C. Clontz, A. C. Seth, Z. Wang, M. Häberle, M. S. Nitschai, N. Neumayer, P. J. Smith, M. Latour, A. Feldmeier-Krause, M. Libralato, A. Bellini   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The evolution of high-z proto-star clusters into local globular clusters

Astronomy & Astrophysics
The James Webb Space Telescope (JWST) detected numerous massive and relatively compact stellar clumps around proto-galaxies at high redshift (z > 0.5).
Della Croce A., Vesperini E., Pascale R., Askar A., Calura F., Dalessandro E., Giersz M.   +6 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

oMEGACat. IV. Constraining the Ages of Omega Centauri Subgiant Branch Stars with HST and MUSE

The Astrophysical Journal
We present age estimates for over 8100 subgiant branch (SGB) stars in Omega Centauri ( ω Cen) to study its star formation history. Our large data set, which combines multi-wavelength Hubble Space Telescope photometry with MUSE metallicities, provides an ...
C. Clontz, A. C. Seth, A. Dotter, M. Häberle, M. S. Nitschai, N. Neumayer, A. Feldmeier-Krause, M. Latour, Z. Wang, S. O. Souza, N. Kacharov, A. Bellini, M. Libralato, R. Pechetti, G. van de Ven, M. Alfaro-Cuello   +15 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

On the Origin of Neutron-capture Elements in r-I and r-II Stars: A Differential-abundance Analysis

The Astrophysical Journal
We present a strictly line-by-line differential analysis of a moderately r -process-enhanced star ( r -I: HD 107752) with respect to a strongly r -process-enhanced star ( r -II: CS 31082-0001) to investigate the possible common origin of their heavy ...
Pallavi Saraf, Thirupathi Sivarani, Timothy C. Beers, Yutaka Hirai, Masaomi Tanaka, Carlos Allende Prieto, Drisya Karinkuzhi   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source