Results 131 to 140 of about 1,811,299 (294)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A Novel Approach to Identifying Substructures through Analysis of Metallicity Distribution Functions

The Astrophysical Journal
We present a new method for identifying Galactic halo substructures accreted from dwarf galaxies by combining metallicity distribution functions (MDFs) with orbital parameters.
Young Kwang Kim, Young Sun Lee, Timothy C. Beers   +2 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Evolving sparse stellar populations

, 2016
We examine the role that stochastic fluctuations in the IMF and in the number of interacting binaries have on the spectro-photometric properties of sparse stellar populations as a function of age and metallicity.
Gustavo Bruzual, Gladis Magris C., Fabiola Hernández-Pérez   +2 more
core   +1 more source

Tracing Early Cosmic Chemical Enrichment: A Uniform XMM-Newton Survey of Metallicity in Galaxy Groups and Clusters

The Astrophysical Journal
Observed metal abundances in the intracluster medium (ICM) of galaxy groups and clusters, Z _ICM , exceed what is expected from present-day stellar populations alone.
Anne E. Blackwell, Joel N. Bregman, Sophia Chan Davis   +2 more
doaj   +1 more source

GALAXY STRUCTURE, STELLAR POPULATIONS, AND STAR FORMATION QUENCHING AT 0.6 ≲ <i>z</i> ≲ 1.2. [PDF]

Astrophys J, 2018
Kim K, Malhotra S, Rhoads JE, Joshi B, Fererras I, Pasquali A.   +5 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Stellar populations in the SAMI Galaxy Survey [PDF]

We present a set of line index-based measurements of the relative α-element abundance, [α/Fe], for up to 2097 galaxies in the Sydney-Australian-Astronomical-Observatory Multi-object Integral-field Spectrograph (SAMI) Galaxy Survey using aperture spectra ...
Watson, Peter Jonathan
core   +1 more source