Results 151 to 160 of about 15,741 (301)

Galaxy interactions in void substructures: Morphology and stellar populations of two triplets from CAVITY

Astronomy & Astrophysics
Context. Cosmic voids, vast, underdense regions of the Universe, serve as unique laboratories for studying galaxy evolution in isolation. Within these voids, galaxy triplets, rare systems of three close galaxies, provide crucial insights into how local ...
Azevedo G. M., Chies-Santos A. L., Riffel R., Perez I., Ferrari F., de Souza R. S., Argudo-Fernandéz M., Bidaran B.   +7 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

oMEGACat. IV. Constraining the Ages of Omega Centauri Subgiant Branch Stars with HST and MUSE

The Astrophysical Journal
We present age estimates for over 8100 subgiant branch (SGB) stars in Omega Centauri ( ω Cen) to study its star formation history. Our large data set, which combines multi-wavelength Hubble Space Telescope photometry with MUSE metallicities, provides an ...
C. Clontz, A. C. Seth, A. Dotter, M. Häberle, M. S. Nitschai, N. Neumayer, A. Feldmeier-Krause, M. Latour, Z. Wang, S. O. Souza, N. Kacharov, A. Bellini, M. Libralato, R. Pechetti, G. van de Ven, M. Alfaro-Cuello   +15 more
doaj   +1 more source

The stellar to sub-stellar masses transition in 47 Tuc

Astronomy & Astrophysics
Context. The study of the globular cluster 47 Tuc offers an opportunity to shed new light on the debated issue of the presence of multiple populations in globular clusters, as recent results from HST photometry and high-resolution spectroscopy outlined ...
Ventura C., Tailo M., Ventura P., D’Antona F., Milone A. P., Marino A. F., Fiumi C.   +6 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

On the Origin of Neutron-capture Elements in r-I and r-II Stars: A Differential-abundance Analysis

The Astrophysical Journal
We present a strictly line-by-line differential analysis of a moderately r -process-enhanced star ( r -I: HD 107752) with respect to a strongly r -process-enhanced star ( r -II: CS 31082-0001) to investigate the possible common origin of their heavy ...
Pallavi Saraf, Thirupathi Sivarani, Timothy C. Beers, Yutaka Hirai, Masaomi Tanaka, Carlos Allende Prieto, Drisya Karinkuzhi   +6 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Studying Stellar Systems with Classical Pulsators [PDF]

, 2018
Classical Cepheids and RR Lyrae are very important primary distance indicators and stellar population tracers, thanks to the relations between pulsation properties and intrinsic stellar parameters. Through the theoretical prediction of these relations as
MARCONI, Marcella, RIPEPI, Vincenzo, Moretti, Maria Ida, MUSELLA, ILARIA, MOLINARO, Roberto   +4 more
core  

Hidden Figures of Globular Clusters: Integrated Stellar Populations Impacted by Hot Subdwarfs

The Astrophysical Journal
Globular clusters (GCs) are fundamental for understanding the integrated light of old stellar populations and galaxy assembly processes. However, the role of hot, evolved stars, such as horizontal branch (HB), extreme HB, and blue stragglers, remains ...
Thayse A. Pacheco, Paula R. T. Coelho, Lucimara P. Martins, Ricardo P. Schiavon, Erik V. R. de Lima, Marcos P. Diaz, Domenico Nardiello, Ronaldo S. Levenhagen, Rogério Riffel, Charles J. Bonatto, Ana L. Chies-Santos   +10 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source