Results 71 to 80 of about 3,799 (315)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Discovery of a Collimated Jet from the Low-luminosity Protostar IRAS 16253−2429 in a Quiescent Accretion Phase with the JWST

The Astrophysical Journal Letters
Investigating Protostellar Accretion (IPA) is a JWST Cycle 1 GO program that uses NIRSpec integral field units and MIRI Medium Resolution Spectrograph to obtain 2.9–28 μ m spectral cubes of young, deeply embedded protostars with luminosities of 0.2–10 ...
Mayank Narang, P. Manoj, Himanshu Tyagi, Dan M. Watson, S. Thomas Megeath, Samuel Federman, Adam E. Rubinstein, Robert Gutermuth, Alessio Caratti o Garatti, Henrik Beuther, Tyler L. Bourke, Ewine F. Van Dishoeck, Neal J. Evans II, Guillem Anglada, Mayra Osorio, Thomas Stanke, James Muzerolle, Leslie W. Looney, Yao-Lun Yang, Pamela Klaassen, Nicole Karnath, Prabhani Atnagulov, Nashanty Brunken, William J. Fischer, Elise Furlan, Joel Green, Nolan Habel, Lee Hartmann, Hendrik Linz, Pooneh Nazari, Riwaj Pokhrel, Rohan Rahatgaonkar, Will R. M. Rocha, Patrick Sheehan, Katerina Slavicinska, Amelia M. Stutz, John J. Tobin, Lukasz Tychoniec, Scott Wolk   +38 more
doaj   +1 more source

Mass, energy, and momentum capture from stellar winds by magnetized and unmagnetized planets: implications for atmospheric erosion and habitability [PDF]

, 2018
Eric G. Blackman, J. A. Tarduno
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Milky Way Project MOBStIRS: Parameterizing Infrared Stellar-wind Bow Shock Morphologies with Citizen Science

The Astronomical Journal
Mass-loss influences stellar evolution, especially for massive stars with strong winds. Stellar wind bow shock nebulae driven by Galactic OB stars can be used to measure mass-loss rates ( $\dot{M}$ ).
Angelica S. Whisnant, Matthew S. Povich, Nikhil Patten, Henry A. Kobulnicky   +3 more
doaj   +1 more source

Clumps in stellar winds [PDF]

ASTRA Proceedings, 2014
Abstract. We discuss the origin and quantification of wind clumping and mass–loss rates (Ṁ), particularly in close proximity to the Eddington (Γ) limit, relevant for very massive stars (VMS). We present evidence that clumping may not be the result of the line-deshadowing instability (LDI), but that clumps are already present in the stellar photosphere.
openaire   +2 more sources

Cosmic-ray acceleration in a supernova remnant shock propagating in a stellar wind with a wind termination shock [PDF]

, 2023
Shoma F. Kamijima, Yutaka Ohira
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Aperture and Resolution Effects on Ultraviolet Star-forming Properties: Insights from Local Galaxies and Implications for High-redshift Observations

The Astrophysical Journal
We present an analysis of the effects of spectral resolution and aperture scale on derived galaxy properties using far-ultraviolet (FUV) spectra of local star-forming galaxies from the International Ultraviolet Explorer ( R ∼ 250, field of view (FOV ...
Ilyse Clark, Danielle A. Berg, Claus Leitherer, Karla Z. Arellano-Córdova, Andreas A. C. Sander   +4 more
doaj   +1 more source