Results 91 to 100 of about 2,711,256 (365)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Stem cell clinical trials [PDF]

, 2013
No description ...
Rosemann, Achim
core  

Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging. [PDF]

, 2017
Intestinal stem cells (ISCs) maintain the midgut epithelium in Drosophila melanogaster Proper cellular turnover and tissue function rely on tightly regulated rates of ISC division and appropriate differentiation of daughter cells.
Abramov, Amcheslavsky, Amcheslavsky, Amcheslavsky, Benard, Biteau, Biteau, Biteau, Buchon, Buchon, Buchon, Christopher L. Koehler, Clark, Clarkson, Coppé, Correia-Melo, D. Leanne Jones, Deng, Greene, Guo, Guy A. Perkins, Hackenbrock, Han, Henchcliffe, Hochmuth, Hur, Jiang, Jiang, Jones, Kashatus, Lee, Lee, Li, Liu, Maeda, Marianes, Mark H. Ellisman, McGuire, Micchelli, Myant, Nakamura, Nicholson, Ohlstein, Ohlstein, Osterwalder, O’Brien, Park, Passos, Poole, Poole, Rana, Rera, Resende, Resnik-Docampo, Roman, Springer, Sykiotis, Takashima, Tian, Twig, Wang, Wang, Wei, Westermann, Yang, Youle, Zeng, Zeng, Zhu   +68 more
core   +1 more source

Skeletal Stem Cells

Development, 2004
Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays. These lineages emerge in a specific sequence during embryonic development and post natal growth, and together comprise a continuous anatomical system, the bone-bone marrow ...
BIANCO, Paolo, P.G. Robey
openaire   +4 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Tankyrase inhibition promotes endocrine commitment of hPSC-derived pancreatic progenitors

Nature Communications
Human pluripotent stem cells (hPSCs) have the potential to differentiate into various cell types, including pancreatic insulin-producing β cells, which are crucial for developing therapies for diabetes.
Frankie Poon, Rangarajan Sambathkumar, Roman Korytnikov, Yasaman Aghazadeh, Amanda Oakie, Paraish S. Misra, Farida Sarangi, M. Cristina Nostro   +7 more
doaj   +1 more source

Osteopetrotic induced pluripotent stem cells derived from patients with different disease-associated mutations by non-integrating reprogramming methods

Stem Cell Research & Therapy, 2019
Background Autosomal recessive osteopetrosis is a genetically and phenotypically heterogeneous disease, caused by defects in osteoclast formation and function.
Fatma Visal Okur, İnci Cevher, Cansu Özdemir, Çetin Kocaefe, Duygu Uçkan Çetinkaya   +4 more
doaj   +1 more source

Chemical approaches to targeting drug resistance cancer stem cells [PDF]

, 2016
STEMCHEM is a COST action aiming to target causes of drug resistance in cancer stem cells. Cancer stem cells are cells which are believed to be responsible for the larger part of the regenerative capacity of cancers.
Blaire Theuma, Krystle, Cassar, Analisse, Micallef, Neville, Passarella, Daniele, Schembri-Wismayer, Pierre, Stipourou, Iona, Suleiman, Sherif   +6 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice

Nature Communications, 2016
Rett syndrome is a neurodevelopmental disorder caused by mutations in Mecp2. Here the authors show that Mecp2 loss-of-function leads to upregulation of the NF-κB pathway, and that reducing NF-κB signalling ameliorates phenotypes of Mecp2-null mice, thus ...
Noriyuki Kishi, Jessica L. MacDonald, Julia Ye, Bradley J. Molyneaux, Eiman Azim, Jeffrey D. Macklis   +5 more
doaj   +1 more source