Results 11 to 20 of about 12,666,103 (318)

Mesenchymal stem cell perspective: cell biology to clinical progress

npj Regenerative Medicine, 2019
The terms MSC and MSCs have become the preferred acronym to describe a cell and a cell population of multipotential stem/progenitor cells commonly referred to as mesenchymal stem cells, multipotential stromal cells, mesenchymal stromal cells, and ...
M. Pittenger, D. Discher, B. Péault, D. Phinney, J. Hare, A. Caplan   +5 more
semanticscholar   +1 more source

Treatment of shoulder osteoarthritis and rotator cuff tears with bone marrow concentrate and whole bone marrow injections

Cogent Medicine, 2019
Background: Human bone marrow has shown promise as a minimally invasive approach in treating a variety of musculoskeletal conditions due to the presence of stem cells, platelets, and growth factors in solution.
Marc Darrow, Brent Shaw, Nicholas Schmidt, Gabrielle Boeger, Saskia Budgett   +4 more
doaj   +1 more source

The Choice of Anticoagulant Influences the Characteristics of Bone Marrow Aspirate Concentrate and Mesenchymal Stem Cell Bioactivity In Vitro

Stem Cells International, 2022
Bone marrow aspirate concentrate (BMC) is commonly used as a therapeutic agent to resolve orthopedic injuries, using its unique cellularity to reduce inflammation and prime the region for repair.
Ryan C. Dregalla, Jessica Ann Herrera, Lucanus Steven Koldewyn, Edward Jeffery Donner   +3 more
doaj   +1 more source

Processing Adipose Tissue Samples in a GMP Environment Standardizes the Use of SVF in Cell Therapy Treatments: Data on 302 Patients

Biomedicines, 2023
Stromal vascular fraction (SVF) cells, together with adipose-derived mesenchymal stem cells, are becoming the tool of choice for many clinical applications.
Martina Cremona, Giulio Rusconi, Alessandro Ferrario, Luca Mariotta, Mauro Gola, Gianni Soldati   +5 more
doaj   +1 more source

Treatment of unresolved lower back pain with platelet-rich plasma injections

Cogent Medicine, 2019
Background: Platelet-Rich Plasma (PRP) is a non-invasive modality that has been used to treat musculoskeletal conditions for the past two decades. Based on our research, there were no publications that studied the effect of PRP on unresloved lower back ...
Marc Darrow, Brent Shaw, Schmidt Nicholas, Xian Li, Gabrielle Boeger   +4 more
doaj   +1 more source

Nitric oxide has contrasting age-dependent effects on the functionality of murine hematopoietic stem cells

Stem Cell Research & Therapy, 2016
Background The success of hematopoietic stem cell (HSC) transplantation is dependent on the quality of the donor HSCs. Some sources of HSCs display reduced engraftment efficiency either because of inadequate number (e.g., fetal liver and cord blood), or ...
Sapana Jalnapurkar, Shweta Singh, Moirangthem Ranjita Devi, Lalita Limaye, Vaijayanti Kale   +4 more
doaj   +1 more source

Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts

Nature Communications, 2022
By coupling robotic cell culture systems with artificial intelligence–powered image analysis, Schiff et al. identify previously unseen characteristics of Parkinson’s disease in patient skin cells that distinguish them from healthy controls.
Lauren Schiff, Bianca Migliori, Ye Chen, Deidre Carter, Caitlyn Bonilla, Jenna Hall, Minjie Fan, Edmund Tam, Sara Ahadi, Brodie Fischbacher, Anton Geraschenko, Christopher J. Hunter, Subhashini Venugopalan, Sean DesMarteau, Arunachalam Narayanaswamy, Selwyn Jacob, Zan Armstrong, Peter Ferrarotto, Brian Williams, Geoff Buckley-Herd, Jon Hazard, Jordan Goldberg, Marc Coram, Reid Otto, Edward A. Baltz, Laura Andres-Martin, Orion Pritchard, Alyssa Duren-Lubanski, Ameya Daigavane, Kathryn Reggio, NYSCF Global Stem Cell Array® Team, Phillip C. Nelson, Michael Frumkin, Susan L. Solomon, Lauren Bauer, Raeka S. Aiyar, Elizabeth Schwarzbach, Scott A. Noggle, Frederick J. Monsma, Daniel Paull, Marc Berndl, Samuel J. Yang, Bjarki Johannesson   +42 more
doaj   +1 more source

Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies

Stem cell research & therapeutics, 2019
Normal wound healing is a dynamic and complex multiple phase process involving coordinated interactions between growth factors, cytokines, chemokines, and various cells. Any failure in these phases may lead wounds to become chronic and have abnormal scar
Azar Nourian Dehkordi, Fatemeh Mirahmadi Babaheydari, Mohammad Chehelgerdi, Shiva Raeisi Dehkordi   +3 more
semanticscholar   +1 more source

Advances in Recellularization of Decellularized Liver Grafts with Different Liver (Stem) Cells: Towards Clinical Applications

Cells, 2023
Liver transplantation is currently the only curative therapy for patients with acute or chronic liver failure. However, a dramatic gap between the number of available liver grafts and the number of patients on the transplantation waiting list emphasizes ...
Burak Toprakhisar, Catherine M. Verfaillie, Manoj Kumar   +2 more
doaj   +1 more source

Clinical applications of stem cell-derived exosomes

Signal Transduction and Targeted Therapy
Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it nevertheless comes with inescapable drawbacks that might limit its clinical translation.
Fei Tan, Xuran Li, Zhao Wang, Jiaojiao Li, K. Shahzad, Jialin C. Zheng   +5 more
semanticscholar   +1 more source