Results 11 to 20 of about 2,387,298 (366)

Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation

Scientific Reports, 2020
Interleukin (IL)-6 is a pleiotropic cytokine involved in the regulation of hematological and immune responses. IL-6 is secreted chiefly by stromal cells, but little is known about its precise role in the homeostasis of human mesenchymal stromal cells ...
Akaitz Dorronsoro, Valérie Lang, Izaskun Ferrin, Jon Fernández-Rueda, Lorea Zabaleta, Estibaliz Pérez-Ruiz, Pilar Sepúlveda, César Trigueros   +7 more
doaj   +1 more source

Institutional imaginaries of publics in stem cell banking: The cases of the UK and Spain [PDF]

, 2013
The UK and Spanish Stem Cell Banks hold politically controversial-but potentially therapeutically beneficial-human embryonic stem cells for distribution to research laboratories globally.
Bharawaj A., Hooper J., Jasanoff S., Neil Stephens, Paul Atkinson, Peter Glasner, Steering Committee for the UK Stem Cell Bank and For the Use of Stem Cell Lines, Steering Committee for the UK Stem Cell Bank and For the Use of Stem Cell Lines, Stem Cell Research Select Committee   +8 more
core   +2 more sources

Stem cells, cancer, and cancer stem cells [PDF]

Nature, 2001
Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine.
Sean J. Morrison, Tannishtha Reya, Tannishtha Reya, Michael F. Clarke, Irving L. Weissman   +4 more
openaire   +4 more sources

Regulation of stem cell dynamics through volume exclusion [PDF]

Garc\'ia-Tejera R, SchumacherL, Grima R. 2022 Regulation of stem cell dynamics through volume exclusion. Proc.R.Soc.A478: 20220376, 2022
Maintenance and regeneration of adult tissues rely on the self-renewal of stem cells. Regeneration without over-proliferation requires precise regulation of the stem cell proliferation and differentiation rates. The nature of such regulatory mechanisms in different tissues, and how to incorporate them in models of stem cell population dynamics, is ...
arxiv   +1 more source

25 years of epidermal stem cell research. [PDF]

, 2012
This is a chronicle of concepts in the field of epidermal stem cell biology and a historic look at their development over time. The past 25 years have seen the evolution of epidermal stem cell science, from first fundamental studies to a sophisticated ...
Aasen, Akashi, Al-Hajj, Armstrong, Artavanis-Tsakonas, Badiavas, Barrandon, Baxter, Bergoglio, Bickenbach, Bickenbach, Bickenbach, Bilousova, Blanpain, Blanpain, Borue, Braun, Braun, Brittan, Budak, Carey, Chang, Charruyer, Charruyer, Chen, Chen, Cheung, Clayton, Cotsarelis, Cotsarelis, Cotsarelis, Deng, Dick, Dotto, Dunnwald, Ehama, Estrach, Fathke, Ferrari, Fortunel, Fuchs, Garza, Ghazizadeh, Ghazizadeh, Ginestier, Harris, Harrison, Haylock, Hess, Hess, Hodgson, Honeycutt, Horvitz, Inoue, Ito, Itoh, Jaks, Jensen, Jensen, Jones, Jones, Jones, Kaur, Kaur, Kaur, Kaur, Knoblich, Kobayashi, Kondo, Koster, Koster, Koster, Lajtha, Langton, Lapidot, Larderet, Lechler, Lemaître, Lerner, Levy, Levy, Li, Li, Lowell, Luo, Lyle, Lyle, Mackenzie, Mackenzie, Mackenzie, Mahjour, Marazzi, Matic, Mavilio, Michel, Mikkola, Morris, Morris, Morrison, Nakamura, Niemann, Nijhof, Notta, Ohyama, Oliver, Oliver, Oshima, Pan, Park, Pavlovitch, Pellegrini, Pellegrini, Popova, Potten, Potten, Potten, Potten, Pouliot, Prince, Purton, Randall, Rangarajan, Rochat, Ruby Ghadially, Santamaria, Sasahara, Sauvageau, Schieke, Schneider, Selver, Senoo, Shackleton, Siminovitch, Smith, Snippert, Spangrude, Spangrude, Strachan, Sudo, Sutherland, Szilvassy, Tani, Taswell, Terunuma, Till, Till, Tolar, Trempus, Trevisan, Triel, Truong, Tumbar, Uitto, van der Wath, Van Zant, Wan, Wan, Watt, Weissman, Weissman, Williams, Wilson, Withers, Withers, Wu, Wu, Xie, Yamamoto, Yilmaz, Yu, Zhou   +170 more
core   +2 more sources

Prostate Stem Cells and Cancer Stem Cells [PDF]

Cold Spring Harbor Perspectives in Medicine, 2018
Stem/progenitor cells play central roles in processes of organogenesis and tissue maintenance, whereas cancer stem cells (CSCs) are thought to drive tumor malignancy. Here, we review recent progress in the identification and analysis of normal prostate stem/progenitor cells as well as putative CSCs in both genetically engineered mouse models as well as
Michael M. Shen, Jia J. Li
openaire   +3 more sources

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]

, 2018
Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat, Broxmeyer, Hal E., Huang, Xinxin, Trinh, Thao   +3 more
core   +1 more source

Stem Cells and Stem Cell Therapy

MedEdPORTAL, 2013
Abstract This team-based learning (TBL) exercise presents hematopoietic malignancies of myeloid origin and invites users to consider appropriate methods of treatment utilizing stem cell therapy. The 100-minute session is structured in traditional TBL format, and all components—including the learning objectives, reading assignments, individual Readiness
Adam Gromley, Zeynep Gromley
openaire   +3 more sources

PTEN, Stem Cells, and Cancer Stem Cells [PDF]

Journal of Biological Chemistry, 2009
Like normal stem cells, "cancer stem cells" have the capacity for indefinite proliferation and generation of new cancerous tissues through self-renewal and differentiation. Among the major intracellular signaling pathways, WNT, SHH, and NOTCH are known to be important in regulating normal stem cell activities, and their alterations are associated with ...
Hong Wu, Reginald Hill
openaire   +3 more sources

Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells

Nature Communications, 2018
The International Stem Cell Initiative tests methods in a multisite study to detect pluripotency and teratoma formation (PluriTest, Embryoid Body and Teratoma methods) in human pluripotent stem cells.
The International Stem Cell Initiative
doaj   +1 more source