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Stem cells in dermatology [PDF]

open access: yesAnais Brasileiros de Dermatologia, 2014
Preclinical and clinical research have shown that stem cell therapy could be a promising therapeutic option for many diseases in which current medical treatments do not achieve satisfying results or cure. This article describes stem cells sources and their therapeutic applications in dermatology today.
Ogliari, Karolyn Sassi   +3 more
openaire   +6 more sources

Advances in Recellularization of Decellularized Liver Grafts with Different Liver (Stem) Cells: Towards Clinical Applications

open access: yesCells, 2023
Liver transplantation is currently the only curative therapy for patients with acute or chronic liver failure. However, a dramatic gap between the number of available liver grafts and the number of patients on the transplantation waiting list emphasizes ...
Burak Toprakhisar   +2 more
doaj   +1 more source

Improving single-cell cloning workflow for gene editing in human pluripotent stem cells [PDF]

open access: yes, 2018
The availability of human pluripotent stem cells (hPSCs) and progress in genome engineering technology have altered the way we approach scientific research and drug development screens.
Chen, Yi-Hsien, Pruett-Miller, Shondra M
core   +2 more sources

Treatment of unresolved lower back pain with platelet-rich plasma injections

open access: yesCogent Medicine, 2019
Background: Platelet-Rich Plasma (PRP) is a non-invasive modality that has been used to treat musculoskeletal conditions for the past two decades. Based on our research, there were no publications that studied the effect of PRP on unresloved lower back ...
Marc Darrow   +4 more
doaj   +1 more source

Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts

open access: yesNature Communications, 2022
By coupling robotic cell culture systems with artificial intelligence–powered image analysis, Schiff et al. identify previously unseen characteristics of Parkinson’s disease in patient skin cells that distinguish them from healthy controls.
Lauren Schiff   +42 more
doaj   +1 more source

Distribution of interstitial stem cells in Hydra [PDF]

open access: yes, 1979
The distribution of interstitial stem cells along the Hydra body column was determined using a simplified cloning assay. The assay measures stem cells as clone-forming units (CFU) in aggregates of nitrogen mustard inactivated Hydra tissue.
Bode   +16 more
core   +2 more sources

When is a stem cell really a stem cell? [PDF]

open access: yesBone Marrow Transplantation, 2003
While bone marrow transplantation has long been established as an effective approach to the clinical management of a variety of malignant and nonmalignant diseases, the future application of pluripotent stem cells in transplant settings promises to deliver this therapy to a much broader range of indications.
openaire   +3 more sources

The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB [PDF]

open access: yes, 2017
Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that normally control stem cell ...
Carnero Moya, Amancio   +4 more
core   +1 more source

Nitric oxide has contrasting age-dependent effects on the functionality of murine hematopoietic stem cells

open access: yesStem Cell Research & Therapy, 2016
Background The success of hematopoietic stem cell (HSC) transplantation is dependent on the quality of the donor HSCs. Some sources of HSCs display reduced engraftment efficiency either because of inadequate number (e.g., fetal liver and cord blood), or ...
Sapana Jalnapurkar   +4 more
doaj   +1 more source

Stem cell decisions:A twist of fate or a niche market? [PDF]

open access: yes, 2014
Establishing and maintaining cell fate in the right place at the right time is a key requirement for normal tissue maintenance. Stem cells are at the core of this process.
Anderson   +112 more
core   +2 more sources

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