Results 51 to 60 of about 2,605,751 (360)

Stem cell boost [PDF]

Current Biology, 2003
AbstractBritain is publicly and privately backing stem-cell research but worries continue about the legal framework scientists face in undergoing such work ...
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Protocol to assess fatal embolism risks from human stem cells

STAR Protocols, 2023
Summary: Here, we present a protocol to identify the pro-embolic sub-population of human adipose-derived multipotent stromal cells (ADSCs) and predict fatal embolism risks from ADSC infusion.
Fei Ma, Jinlai Zhang, Xin Jin, Pengfei Han, Yuling Liu, Ting Zhang, Kaijing Yan, Y. James Kang   +7 more
doaj   +1 more source

MicroRNAs as Important Regulators Mediate the Multiple Differentiation of Mesenchymal Stromal Cells

Frontiers in Cell and Developmental Biology, 2021
MicroRNAs (miRNAs) are endogenous short non-encoding RNAs which play a critical role on the output of the proteins, and influence multiple biological characteristics of the cells and physiological processes in the body.
Chao Yang, Maowen Luo, Yu Chen, Min You, Qiang Chen, Qiang Chen   +5 more
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The individuality of stem cells [PDF]

BMC Biology, 2011
Lander BMC Biology 2011, 9:40 http://www.biomedcentral.com/1741-7007/9/40 CO M M E N T Open Access The individuality of stem cells Arthur D Lander* When a group of immigrants moves into a community in large numbers, so much attention is usually focused on how they are different – in language, customs, appearance, and so on – from everyone else, that ...
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YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells

Nature Communications, 2019
Pluripotent stem cells can be directed into insulin-producing beta cells in vitro. Here, the authors show that downregulation of YAP, an effector of the Hippo pathway, enhances endocrine progenitor differentiation and the generation of beta-cells with ...
Edwin A. Rosado-Olivieri, Kendall Anderson, Jennifer H. Kenty, Douglas A. Melton   +3 more
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Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

eLife, 2014
Dysfunction or death of pancreatic β cells underlies both types of diabetes. This functional decline begins with β cell stress and de-differentiation. Current drugs for type 2 diabetes (T2D) lower blood glucose levels but they do not directly alleviate β
Barak Blum, Adam N Roose, Ornella Barrandon, René Maehr, Anthony C Arvanites, Lance S Davidow, Jeffrey C Davis, Quinn P Peterson, Lee L Rubin, Douglas A Melton   +9 more
doaj   +1 more source

PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development

Communications Biology, 2022
The transcription factor PU.1 recruits c-Jun as a co-activator to promoters without AP-1 binding sites, and mice with point mutations in PU.1 that disrupts the interaction between PU1 and c-Jun have defects in PU.1 dependent blood lineages, including ...
Xinhui Zhao, Boris Bartholdy, Yukiya Yamamoto, Erica K. Evans, Meritxell Alberich-Jordà, Philipp B. Staber, Touati Benoukraf, Pu Zhang, Junyan Zhang, Bon Q. Trinh, John D. Crispino, Trang Hoang, Mahmoud A. Bassal, Daniel G. Tenen   +13 more
doaj   +1 more source

WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics [PDF]

, 2009
Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in non-adherent cultures.
A de la Taille, A Glinka, A van Bokhoven, AA George, AP Verhagen, AS Waller, AT Collins, AT Collins, AT Collins, B Hoang, B Mao, BA Reynolds, C Lo Celso, C Wissmann, CC Carson 3rd, CI Truica, CL Hall, CL Hall, D Beier, D Bonnet, D Masiello, D Mizrak, DA Lawson, David M Prowse, DK Singla, DL Hudson, DL Hudson, DP Petrylak, DR Chesire, EM Hurt, G Dontu, G Gu, G Shaw, G Shaw, GD Richardson, GJ van Leenders, GL Shaw, GN Thalmann, H Clevers, H Li, H Zhu, HF English, Isabelle Bisson, IV Litvinov, IV Litvinov, J Miki, JA Schalken, JE Visvader, JM Adams, KD Bunting, KG Leong, L Adam, L Patrawala, L Patrawala, L Patrawala, L Ricci-Vitiani, L Vezzoni, L Xin, L Xin, LE Pascal, LG Wang, M Al-Hajj, M Locke, M Verras, MJ Linja, MS Chen, MS Wicha, N Uchida, PN Kelly, RI Bhatt, S Signoretti, S Weiss, S Zhou, SI Hwang, SK Singh, SM Janes, SV Shmelkov, T Hara, T Nikolova, T Reya, WJ Huss, Y Katoh, Y Lu   +82 more
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Stem Cells and Irradiation [PDF]

Cells, 2021
The main difficulty of radiotherapy is to destroy cancer cells without depletion of healthy tissue [...]
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Multiple feedback loops through cytokinin signaling control stem cell number within the Arabidopsis shoot meristem [PDF]

, 2009
A central unanswered question in stem cell biology, both in plants and in animals, is how the spatial organization of stem cell niches are maintained as cells move through them.
Anders, Birnbaum, Brand, C. Ohno, Clark, Clark, Clark, Clark, E. M. Meyerowitz, Fletcher, Fletcher, Gallois, Gallois, Geier, Gordon, Haecker, Jasinski, Jonsson, Kayes, Kurakawa, Laux, Leibfried, Long, Mahonen, Mayer, Muller, Muller, S. P. Gordon, Sablowski, Schoof, Skoog, Tucker, V. S. Chickarmane, Yanai   +33 more
core   +2 more sources