Results 51 to 60 of about 2,387,298 (366)
Nature Communications, 2022 By coupling robotic cell culture systems with artificial intelligence–powered image analysis, Schiff et al. identify previously unseen characteristics of Parkinson’s disease in patient skin cells that distinguish them from healthy controls.
Lauren Schiff +42 more
doaj +1 more source
MicroRNAs as Important Regulators Mediate the Multiple Differentiation of Mesenchymal Stromal Cells
Frontiers in Cell and Developmental Biology, 2021 MicroRNAs (miRNAs) are endogenous short non-encoding RNAs which play a critical role on the output of the proteins, and influence multiple biological characteristics of the cells and physiological processes in the body.
Chao Yang +5 more
doaj +1 more source
Cholangiocytes: Cell transplantation [PDF]
, 2017 Background:Due to significant limitations to the access to orthotropic liver transplantation, cell therapies forliver diseases have gained large interest worldwide.Scope of review:To revise current literature dealing with cell therapy for liver diseases.
Alvaro, Domenico +5 more
core +1 more source
The individuality of stem cells [PDF]
BMC Biology, 2011 Lander BMC Biology 2011, 9:40 http://www.biomedcentral.com/1741-7007/9/40 CO M M E N T Open Access The individuality of stem cells Arthur D Lander* When a group of immigrants moves into a community in large numbers, so much attention is usually focused on how they are different – in language, customs, appearance, and so on – from everyone else, that ...
openaire +6 more sources
Nature Communications, 2019 Pluripotent stem cells can be directed into insulin-producing beta cells in vitro. Here, the authors show that downregulation of YAP, an effector of the Hippo pathway, enhances endocrine progenitor differentiation and the generation of beta-cells with ...
Edwin A. Rosado-Olivieri +3 more
doaj +1 more source
Dynamics of cell-type transition mediated by epigenetic modifications [PDF]
arXiv, 2023 Maintaining tissue homeostasis requires appropriate regulation of stem cell differentiation. The Waddington landscape posits that gene circuits in a cell form a potential landscape of different cell types, wherein cells follow attractors of the probability landscape to develop into distinct cell types.
arxiv
Using Deep Learning to Predict Neural Stem Cell Differentiation in Regenerative Medicine [PDF]
arXiv, 2023 Over one in three people are affected by neurodegenerative disorders. Neural stem cells, which are multipotent regenerative cells with the potential to differentiate into any of the neural cell types, have immense therapeutic potential for treating neurological disorders.
arxiv
Modeling tumorspheres reveals cancer stem cell niche building and plasticity [PDF]
, 2019 Cancer stem cells have been shown to be critical to the development of a variety of solid cancers. The precise interplay mechanisms between cancer stem cells and the rest of a tissue are still not elucidated. To shed light on the interactions between stem and non-stem cancer cell populations we develop a two-population mathematical model, which is ...
arxiv +1 more source
Cancer stem cells display extremely large evolvability: alternating plastic and rigid networks as a potential mechanism [PDF]
Seminars in Cancer Biology 30 (2015) 42-51, 2013 Cancer is increasingly perceived as a systems-level, network phenomenon. The major trend of malignant transformation can be described as a two-phase process, where an initial increase of network plasticity is followed by a decrease of plasticity at late stages of tumor development. The fluctuating intensity of stress factors, like hypoxia, inflammation
arxiv +1 more source
Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]
, 2018 Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita +6 more
core +3 more sources