Targeting the stem cell niche micro-environment as therapeutic strategies in aging
Frontiers in Cell and Developmental Biology, 2023 Adult stem cells (ASCs) reside throughout the body and support various tissue. Owing to their self-renewal capacity and differentiation potential, ASCs have the potential to be used in regenerative medicine. Their survival, quiescence, and activation are
Raheleh Farahzadi +3 more
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Notch signaling sculpts the stem cell niche
Frontiers in Cell and Developmental Biology, 2022 Adult stem cells depend on their niches for regulatory signaling that controls their maintenance, division, and their progeny differentiation. While communication between various types of stem cells and their niches is becoming clearer, the process of ...
Ana-Maria Zamfirescu +2 more
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Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components [PDF]
Stem Cells International, 2017 The intestinal epithelium comprises a monolayer of polarised columnar cells organised along the crypt-villus axis. Intestinal stem cells reside at the base of crypts and are constantly nourished by their surrounding niche for maintenance, self-renewal ...
Laween Meran, Anna Baulies, Vivian Li
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The SVZ stem cell niche–components, functions, and in vitro modelling [PDF]
Frontiers in Cell and Developmental Biology, 2023 Neocortical development depends on the intrinsic ability of neural stem and progenitor cells to proliferate and differentiate to generate the different kinds of neurons in the adult brain.
Nesil Eşiyok, Michael Heide
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Neural stem cell niche heterogeneity. [PDF]
Seminars in Cell & Developmental Biology, 2019 In mammals, new neurons can be generated from neural stem cells in specific regions of the adult brain. Neural stem cells are characterized by their abilities to differentiate into all neural lineages and to self-renew. The specific microenvironments regulating neural stem cells, commonly referred to as neurogenic niches, comprise multiple cell ...
J. Andreotti +10 more
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Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyIntestinal stem cells replenish the epithelium throughout life by continuously generating intestinal epithelial cell types, including absorptive enterocytes, and secretory goblet, endocrine, and Paneth cells. This process is orchestrated by a symphony of
Michaela Quintero, Linda C. Samuelson
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Stem Cell Research & Therapy, 2019 Background Injury of stem cell niches may disturb tissue homeostasis and regeneration coordinated by specific niche components. Yet, the mechanisms of stem cell niche restoration remain poorly understood.
Georgy Sagaradze +9 more
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The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells? [PDF]
Cell Stem Cell, 2015 Vicki Plaks, Niwen Kong, Zena Werb
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IGFBP-2 and IGF-II: Key Components of the Neural Stem Cell Niche? Implications for Glioblastoma Pathogenesis. [PDF]
Int J Mol SciHarland AJ, Perks CM.
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3D Tumor-Engineered Model Replicating the Osteosarcoma Stem Cell Niche and <i>In Vivo</i> Tumor Complexity. [PDF]
ACS Appl Mater InterfacesBassi G +8 more
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