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Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyIntestinal stem cells replenish the epithelium throughout life by continuously generating intestinal epithelial cell types, including absorptive enterocytes, and secretory goblet, endocrine, and Paneth cells. This process is orchestrated by a symphony of
Michaela Quintero, Linda C. Samuelson
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Ocular surface microbiota: Ophthalmic infectious disease and probiotics
Frontiers in Microbiology, 2022 Recently, increasing studies have emphasized the importance of commensal bacteria in humans, including microbiota in the oral cavity, gut, vagina, or skin.
Ming-Cheng Chiang +2 more
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KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state
Journal of Hematology & Oncology, 2021 Background Little is known about endogenous inhibitors of angiogenic growth factors. In this study, we identified a novel endogenous anti-angiogenic factor expressed in pericytes and clarified its underlying mechanism and clinical significance.
Jin-Woo Lee +16 more
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Biomaterials Research, 2023 Background Although vasospastic angina (VSA) is known to be caused by coronary artery spasm, no study has fully elucidated the exact underlying mechanism. Moreover, in order to confirm VSA, patients should undergo invasive coronary angiography with spasm
Han-Mo Yang +14 more
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Targeting the stem cell niche micro-environment as therapeutic strategies in aging
Frontiers in Cell and Developmental Biology, 2023 Adult stem cells (ASCs) reside throughout the body and support various tissue. Owing to their self-renewal capacity and differentiation potential, ASCs have the potential to be used in regenerative medicine. Their survival, quiescence, and activation are
Raheleh Farahzadi +3 more
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The SVZ stem cell niche–components, functions, and in vitro modelling
Frontiers in Cell and Developmental Biology, 2023 Neocortical development depends on the intrinsic ability of neural stem and progenitor cells to proliferate and differentiate to generate the different kinds of neurons in the adult brain.
Nesil Eşiyok, Michael Heide
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Notch signaling sculpts the stem cell niche
Frontiers in Cell and Developmental Biology, 2022 Adult stem cells depend on their niches for regulatory signaling that controls their maintenance, division, and their progeny differentiation. While communication between various types of stem cells and their niches is becoming clearer, the process of ...
Ana-Maria Zamfirescu +2 more
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Distant activation of Notch signaling induces stem cell niche assembly.
PLoS Genetics, 2021 Here we show that multiple modes of Notch signaling activation specify the complexity of spatial cellular interactions necessary for stem cell niche assembly.
Andriy S Yatsenko, Halyna R Shcherbata
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eLife, 2014 Mesenchymal stem cells (MSCs) and osteolineage cells contribute to the hematopoietic stem cell (HSC) niche in the bone marrow of long bones. However, their developmental relationships remain unclear.
Joan Isern +7 more
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Stem Cell Research, 2015 We have previously shown that pluripotent stem cells can be induced from adult somatic cells which were exposed to protein extracts isolated from mouse embryonic stem cells (mESC).
Yoo-Wook Kwon +6 more
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