Results 31 to 40 of about 193,899 (265)
Metabolic Teamwork in the Stem Cell Niche [PDF]
, 2018 Nearby cells can support stem cell differentiation, but the metabolic activities in stem cell niches are unknown. A recent study (Rodríguez-Colman et al., 2017) reveals a metabolic partnership in the intestinal stem cell niche: glycolysis in niche Paneth
Roper, Jatin, Yilmaz, Omer
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Patient-derived induced pluripotent stem cells for models of cancer and cancer stem cell research
Journal of the Formosan Medical Association, 2018 Induced pluripotent stem cells (iPSCs) are embryonic stem cell-like cells reprogrammed from somatic cells by four transcription factors, OCT4, SOX2, KLF4 and c-MYC.
Hsiao-Mei Chao, Edward Chern
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Biophysical regulation of stem cell behavior within the niche. [PDF]
, 2012 Stem cells reside within most tissues throughout the lifetimes of mammalian organisms. To maintain their capacities for division and differentiation and thereby build, maintain, and regenerate organ structure and function, these cells require extensive ...
Conway, Anthony, Schaffer, David V
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Cell Reports, 2018 Summary: Homeostasis in adult tissues depends on the precise regulation of stem cells and their surrounding microenvironments, or niches. Here, we show that the cell cycle inhibitor and tumor suppressor Retinoblastoma (RB) is a critical regulator of ...
Leah J. Greenspan, Erika L. Matunis
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An Integrated Gene Regulatory Network Controls Stem Cell Proliferation in Teeth [PDF]
, 2012 Epithelial stem cells reside in specific niches that regulate their self-renewal and differentiation, and are responsible for the continuous regeneration of tissues such as hair, skin, and gut.
Alonso, Maria T +9 more
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Stem Cell Reports, 2018 Summary: The regulatory mechanisms that control neural stem cell (NSC) activation in the adult ventricular-subventricular zone (V-SVZ) stem cell niche have been the focus of intense investigation, yet how the niche first develops and organizes is poorly ...
Xiwei Shan +3 more
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Bioengineering, 2021 The recapitulation of the stem cell microenvironment is an emerging area of research that has grown significantly in the last 10 to 15 years. Being able to understand the underlying mechanisms that relate stem cell behavior to the physical environment in
David H. Ramos-Rodriguez +3 more
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Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila Testis [PDF]
, 2016 The Drosophila testis is a well-established system for studying stem cell self-renewal and competition. In this tissue, the niche supports two stem cell populations, germ line stem cells (GSCs), which give rise to sperm, and somatic stem cells called ...
Amoyel, Marc +4 more
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E-cadherin is required for centrosome and spindle orientation in Drosophila male germline stem cells. [PDF]
PLoS ONE, 2010 Many adult stem cells reside in a special microenvironment known as the niche, where they receive essential signals that specify stem cell identity.
Mayu Inaba +4 more
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Targeting self-renewal pathways in myeloid malignancies [PDF]
, 2013 A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
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