Results 71 to 80 of about 817,109 (355)
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Runx2+ Niche Cells Maintain Incisor Mesenchymal Tissue Homeostasis through IGF Signaling
Cell Reports, 2020 Summary: Stem cell niches provide a microenvironment to support the self-renewal and multi-lineage differentiation of stem cells. Cell-cell interactions within the niche are essential for maintaining tissue homeostasis.
Shuo Chen +8 more
doaj +1 more source
Genes & Development, 2018 Here, Shimotohno et al. investigated how upstream factors that regulate WUS and WOX genes converge to position organizer cells during embryogenesis, initiation of new lateral organs, and regeneration after tissue damage in Arabodopsis.
Akie Shimotohno +3 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah +8 more
wiley +1 more source
Stem Cells: Specifying Stem-Cell Niches in the Worm [PDF]
Current Biology, 2006 Recent work has shown that components of the Wnt signaling pathway directly activate a homeodomain transcription factor so as to specify the cell fate that provides niche function to germline stem cells in the nematode Caenorhabditis elegans.
Van Hoffelen, Samantha +1 more
openaire +2 more sources
FEBS Open Bio, EarlyView.We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan +6 more
wiley +1 more source
Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells
Nature Cell Biology, 2019 Haematopoietic stem cells (HSCs) are maintained by bone marrow niches in vivo1,2, but the ability of niche cells to maintain HSCs ex vivo is markedly diminished.
F. Nakahara +13 more
semanticscholar +1 more source
Cell Death and Disease, 2020 Radiotherapy for head and neck cancer is associated with impairment of salivary gland function and consequent xerostomia, which has a devastating effect on the quality of life of the patients.
Xiaohong Peng +7 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Engineering Hydrogel Microenvironments to Recapitulate the Stem Cell Niche.
Annual Review of Biomedical Engineering, 2018 Stem cells are a powerful resource for many applications including regenerative medicine, patient-specific disease modeling, and toxicology screening.
C. Madl, S. Heilshorn
semanticscholar +1 more source