Sirtuins 1–7 expression in human adipose-derived stem cells from subcutaneous and visceral fat depots: influence of obesity and hypoxia [PDF]
, 2016 The sirtuin family comprises seven NAD+-dependent deacetylases which control the overall health of organisms through the regulation of pleiotropic metabolic pathways.
Di Rocco, Giuliana +5 more
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Mesenchymal stem cell-based therapy for ischemic stroke [PDF]
, 2016 Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available.
Anderson, JD +20 more
core +2 more sources
Subventricular zone stem cells are heterogeneous with respect to their embryonic origins and neurogenic fates in the adult olfactory bulb [PDF]
, 2007 Wedetermined the embryonic origins of adult forebrain subventricular zone (SVZ) stem cells by Cre-lox fate mapping in transgenic mice. We found that all parts of the telencephalic neuroepithelium, including the medial ganglionic eminence and lateral ...
C.H. Papadimitriou +8 more
core +4 more sources
Long term in vitro expansion of epithelial stem cells enabled by pharmacological inhibition of PAK1-ROCK-Myosin II and TGF-β signaling [PDF]
, 2018 Summary: Despite substantial self-renewal capability in vivo, epithelial stem and progenitor cells located in various tissues expand for a few passages in vitro in feeder-free condition before they succumb to growth arrest.
Challberg, Sharon S +7 more
core +2 more sources
Chemical approaches to targeting drug resistance cancer stem cells [PDF]
, 2016 STEMCHEM is a COST action aiming to target causes of drug resistance in cancer stem cells. Cancer stem cells are cells which are believed to be responsible for the larger part of the regenerative capacity of cancers.
Blaire Theuma, Krystle +6 more
core +1 more source
Characterization of interstitial stem cells in hydra by cloning [PDF]
, 1977 A procedure has been developed for cloning interstitial stem cells from hydra. Clones are prepared by introducing small numbers of viable cells into aggregates of nitrogen mustard-inactivated host tissue.
David, Charles N., Murphy, Susan
core +1 more source
Physiological conditions influencing regenerative potential of stem cells [PDF]
, 2016 Stem cells are being used in the treatment of cardivovascular diseases. Here, we review the physiologic and pathologic conditions that impact the regenerative potential of stem cells in the treatment of cardiovascular diseases which include the influence
Avitabile, Daniele +3 more
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Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut [PDF]
, 2015 Adult tissue homeostasis requires a tight balance between the removal of old or damaged cells and the production of new ones. Such processes are usually driven by dedicated stem cells that reside within specific tissue locations or niches.
Carroll, Lynsey +2 more
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Stem cells conditioned medium: a new approach to skin wound healing management [PDF]
, 2014 Stem cell biology has gained remarkable interest in recent years, driven by the hope of finding cures for numerous diseases including skin wound healing through transplantation medicine.
Govindasamy, V. +4 more
core +1 more source
Experimental Biology and Medicine, 2001 Within the bone marrow stroma there exists a subset of nonhematopoietic cells referred to as mesenchymal stem or mesenchymal progenitor cells. These cells can be ex vivo expanded and induced, either in vitro or in vivo, to terminally differentiate into osteoblasts, chondrocytes, adipocytes, tenocytes, myotubes, neural cells, and hematopoietic ...
Minguell, JJ, Erices, A, Conget, P
openaire +6 more sources