Results 71 to 80 of about 1,695,865 (287)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Utilization of Viable Bone Marrow Derivat Stem Cells Through an Adaption in Low Oxigen Tension as an Attempt to Increase Cellular Transplantation Efficacy for Spermatogenesis Process [PDF]

, 2013
Cellular transplantation using stem cells provides very promising solutions in the regeneration and repairment of cells that have experienced degeneration where recovery through medical or surgical intervension is impossible.
Bumi, C. (Candra), Hariadi, M. (Mas’ud), Helen, H. (Helen), Mardi, S. W. (Sri), Mulyani, M. (Mulyani), Prasetyo, R. H. (R), Purwati, P. (Purwati), Rantam, F. A. (Fedik), Safitri, E. (Erma), Utama, S. (Suzanita)   +9 more
core   +3 more sources

Signs of immune dysregulation in second-trimester maternal blood RNA profiles in late-onset preeclampsia

Scientific Reports
Preeclampsia (PE) is a hypertensive disorder that affects 5% of pregnancies. It is characterized by new-onset hypertension and proteinuria after 20 weeks of gestation. We investigated maternal second-trimester peripheral blood gene expression profiles to
Gamze Yazgeldi Gunaydin, Sini Ezer, Juho Wedenoja, Katri Räikkönen, Juha Kere, Satu Wedenoja, Shintaro Katayama   +6 more
doaj   +1 more source

Latest Developments in Early Detection and Effective Treatment of Cancer: A Meeting Report [PDF]

Cell Journal
Despite a lower estimated rate of cancer incidence in Iran compared to the global average, the trend is unfortunatelyincreasing. This necessitates the implementation of early detection of cancer and targeted therapies to effectively treatvarious types of
Morvarid Ghattan, Niloofar Bajool, Mina Pahlavanneshan, Melika Zamanian, Sharif Moradi   +4 more
doaj   +1 more source

Pluripotent human stem cells: Standing on the shoulders of giants [PDF]

, 2016
The advent of human pluripotent stem cells, with the first derivation of human embryonic stem cells in 1998, and of human induced pluripotent stem cells in 2007, has ushered in an era of considerable excitement about the prospects of using these cells to
Andrews, P.W., Damjanov, I.
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts. [PDF]

, 2013
Copyright: 2013 Hermann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
A Jemal, A Jimeno, Anamaria Balic, Annette Bakker, Bruno Sainz, C Li, C Li, Christopher Heeschen, D Cosco, E Gallmeier, E Lonardo, E Lonardo, E Lonardo, E Matano, EA Collisson, Elena Garcia, Hana Algül, KP Olive, M Vandana, Mallaredy Vandana, Manuel Hidalgo, ML Rothenberg, MT Mueller, P Ferruzzi, PA Philip, Patrick C. Hermann, Patrizia Tunici, PC Hermann, PC Hermann, S Asuthkar, S Bao, S Jones, Sanjeeb K. Sahoo, Sara M. Trabulo, Stephan A. Hahn, T Conroy, T Reya, Y Wang   +37 more
core   +4 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo

Molecular Cancer, 2023
Background Acute leukemias represent deadly malignancies that require better treatment. As a challenge, treatment is counteracted by a microenvironment protecting dormant leukemia stem cells. Methods To identify responsible surface proteins, we performed
Ehsan Bahrami, Jan Philipp Schmid, Vindi Jurinovic, Martin Becker, Anna-Katharina Wirth, Romina Ludwig, Sophie Kreissig, Tania Vanessa Duque Angel, Diana Amend, Katharina Hunt, Rupert Öllinger, Roland Rad, Joris Maximilian Frenz, Maria Solovey, Frank Ziemann, Matthias Mann, Binje Vick, Christian Wichmann, Tobias Herold, Ashok Kumar Jayavelu, Irmela Jeremias   +20 more
doaj   +1 more source

Stem cell therapies for treating osteoarthritis: prescient or premature? [PDF]

, 2014
There has been unprecedented interest in recent years in the use of stem cells as therapy for an array of diseases in companion animals. Stem cells have already been deployed therapeutically in a number of clinical settings, in particular the use of ...
Banks, Tania A., Whitworth, Deanne J.
core   +1 more source