Results 51 to 60 of about 69,259,824 (258)

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Embryonic and induced pluripotent stem cells: understanding, creating, and exploiting the nano-niche for regenerative medicine.

, 2013
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the capacity to differentiate into any specialized cell type of the human body, and therefore, ESC/iPSC-derived cell types offer great potential for regenerative medicine ...
Kingham, Emma Jayne, Richard O.C. Oreffo, Oreffo, Richard O.C., Emmajayne Kingham   +3 more
core   +1 more source

Metabolic costs and trade-offs of hypermetabolism in human motor neurons with ATP synthase deficiency

Communications Biology
Hypermetabolism, a futile cycle of energy production and consumption, has been proposed as an adaptative response to deficiencies in mitochondrial oxidative phosphorylation. However, the cellular costs of hypermetabolism remain largely unknown.
Rubén Torregrosa-Muñumer, Jeremi Turkia, Rumeysa Ermiş, Jouni Kvist, Sandra Harjuhaahto, Jana Pennonen, Ville Hietakangas, Emil Ylikallio, Henna Tyynismaa   +8 more
doaj   +1 more source

Mesenchymal Stem Cells Alleviate Moderate-to-Severe Psoriasis by Reducing the Production of Type I Interferon (IFN-I) by Plasmacytoid Dendritic Cells (pDCs)

Stem Cells International, 2019
The anti-inflammatory and immunomodulatory properties of mesenchymal stem cells (MSCs) have been proposed to be involved in some autoimmune diseases and have been successfully tested in patients and mice.
Maosheng Chen, Jing Peng, Qi Xie, Na Xiao, Xian Su, Hua Mei, Yeping Lu, Jia Zhou, Yanni Dai, Siqi Wang, Chuang Li, Ge Lin, Lamei Cheng   +12 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Costs and Benefits of Stem Cell Research and Treatment: Media Presentation and Audience Understanding in Hungary [PDF]

, 2010
This study examined the press coverage and audience understanding of the costs and benefits of stem cell research/treatment in Hungary. A content analysis of five newspapers and a focus group study was conducted.
Lilla Vicsek, Vicsek, Lilla
core   +1 more source

The Continued Absence of Functional Germline Stem Cells in Adult Ovaries [PDF]

, 2022
Ovaries are central to development, fertility, and reproduction of women. A particularly interesting feature of ovaries is their accelerated aging compared to other tissues, leading to loss of function far before other organs senesce. The limited pool of
Yoshihara, Masahito, Zhao, Cheng, Lanner, Fredrik, Katayama, Shintaro, Damdimopoulos, Anastasios, Wagner, Magdalena, Petropoulos, Sophie, Kere, Juha, Damdimopoulou, Pauliina, Lanner, F,, Petropoulos, S,, Damdimopoulou, P,, Zhao, C,, Katayama, S,, Wagner, M, Damdimopoulos, A,, Kere, J,, Yoshihara, M,   +17 more
core   +1 more source

Apolipoproteins have a major role in cellular tumor dormancy in triple negative breast cancer: In-silico study

Scientific Reports
Triple-negative breast cancer (TNBC) lacks estrogen, progesterone, and human epidermal growth factor receptors and has a poor prognosis as it is resistant to chemotherapy.
Zaynab El-Gammal, Usama Bakry, Ahmed F. El-Sayed, Toka A. Ahmed, Gehad Atef Oura, Shimaa E. Elshenawy, Nagwa El-Badri, Amin F. Romany, Khaled Amer, Tarek Elnagdy, Osama Mahmoud Azmy, Tarek Taha Ahmed Ali   +11 more
doaj   +1 more source

The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α

Nature Communications, 2022
The TYK2 gene is associated with development of type 1 diabetes. Here the authors show that TYK2 regulates β-cell development, but at the same time TYK2 inhibition in the islets prevents IFNα responses and enhances their survival against CD8+ T-cell ...
Vikash Chandra, Hazem Ibrahim, Clémentine Halliez, Rashmi B. Prasad, Federica Vecchio, Om Prakash Dwivedi, Jouni Kvist, Diego Balboa, Jonna Saarimäki-Vire, Hossam Montaser, Tom Barsby, Väinö Lithovius, Isabella Artner, Swetha Gopalakrishnan, Leif Groop, Roberto Mallone, Decio L. Eizirik, Timo Otonkoski   +17 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source