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Leydig cells: From stem cells to aging
Molecular and Cellular Endocrinology, 2009 Leydig cells are the testosterone-producing cells of the testis. The adult Leydig cell population ultimately develops from undifferentiated mesenchymal-like stem cells present in the interstitial compartment of the neonatal testis. Four distinct stages of adult Leydig cell development have been identified and characterized: stem Leydig cells ...
Haolin Chen, Ren-Shan Ge, Barry R Zirkin
exaly +5 more sources
The effects of testicular aging on Leydig cells and the application of stem cells in restoring Leydig cells function [PDF]
Reproductive Biology and EndocrinologyAbstract With the global population aging at an accelerated pace, testicular aging and its associated male health issues have garnered increasing attention. Testicular aging encompasses both age-related physiological decline and premature or pathological aging caused by various pathogenic factors.
Zhu WB +4 more
exaly +4 more sources
Endosialin defines human stem Leydig cells with regenerative potential. [PDF]
Hum Reprod, 2020 Abstract STUDY QUESTION Is endosialin a specific marker of human stem Leydig cells (SLCs) with the ability to differentiate into testosterone-producing Leydig cells (LCs) in vitro and in vivo? SUMMARY ANSWER Endosialin is a specific ...
Xia K +6 more
europepmc +4 more sources
Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig Cells. [PDF]
Front Physiol, 2017 Adult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone. ALCs develop postnatally from a pool of stem cells, referred to as stem Leydig cells (SLCs). SLCs are spindle-shaped cells that lack steroidogenic cell markers, including luteinizing hormone (LH) receptor and 3β-hydroxysteroid dehydrogenase. The commitment of
Ye L, Li X, Li L, Chen H, Ge RS.
europepmc +5 more sources
Dexamethasone suppresses the differentiation of stem Leydig cells in rats in vitro. [PDF]
BMC Pharmacol Toxicol, 2019 It is an established fact that excess of glucocorticoids could cause the harmful effects, such as suppression on the male reproduction. Although glucocorticoids pharmacologically inhibit the Leydig cell function, their roles in Leydig cell development are unclear.
Zhang J +8 more
europepmc +5 more sources
Stem Leydig cells: From fetal to aged animals [PDF]
Birth Defects Research Part C: Embryo Today Reviews, 2010 AbstractLeydig cells are the testosterone‐producing cells of the testis. The adult Leydig cell (ALC) population ultimately develops from undifferentiated mesenchymal‐like stem cells present in the interstitial compartment of the neonatal testis. Distinct stages of ALC development have been identified and characterized.
Haolin Chen, Barry R Zirkin
exaly +3 more sources
Leydig cell stem cells: Identification, proliferation and differentiation [PDF]
Molecular and Cellular Endocrinology, 2017 Adult Leydig cells develop from undifferentiated mesenchymal-like stem cells (stem Leydig cells, SLCs) present in the interstitial compartment of the early postnatal testis. Putative SLCs also have been identified in peritubular and perivascular locations of the adult testis.
Haolin Chen, Ren-Shan Ge, Barry R Zirkin
exaly +3 more sources
Stem Leydig Cells in the Adult Testis: Characterization, Regulation and Potential Applications. [PDF]
Endocr Rev, 2020 Abstract Androgen deficiency (hypogonadism) affects males of all ages. Testosterone replacement therapy (TRT) is effective in restoring serum testosterone and relieving symptoms. TRT, however, is reported to have possible adverse effects in part because administered testosterone is not produced in response to the hypothalamic–pituitary ...
Chen P, Zirkin BR, Chen H.
europepmc +3 more sources
Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation. [PDF]
Adv Sci (Weinh)Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Y +6 more
europepmc +2 more sources
Transplanted human p75-positive stem Leydig cells replace disrupted Leydig cells for testosterone production. [PDF]
Cell Death Dis, 2017 AbstractPrevious studies have demonstrated that rodent stem Leydig cell (SLC) transplantation can partially restore testosterone production in Leydig cell (LC)-disrupted or senescent animal models, which provides a promising approach for the treatment of hypogonadism.
Zhang M +11 more
europepmc +4 more sources