Results 11 to 20 of about 4,949,444 (161)

Differentiation of adult-type Leydig cells occurs in gonadotrophin-deficient mice [PDF]

, 2003
During mammalian testis development distinct generations of fetal and adult Leydig cells arise. Luteinising hormone (LH) is required for normal adult Leydig cell function and for the establishment of normal adult Leydig cell number but its role in the ...
Baker, P.J., Johnston, H., Abel, M., Charlton, H.M., O'Shaughnessy, P.J.   +4 more
core   +9 more sources

Identification of Stem Leydig Cells Derived from Pig Testicular Interstitium. [PDF]

Stem Cells Int, 2017
Stem Leydig cells (SLCs), located in the testicular interstitial compartment in the mammalian testes, are capable of differentiating to testosterone-synthesizing Leydig cells (LCs), thus providing a new strategy for treating testosterone deficiency. However, no previous reports have identified and cultured SLCs derived from the pig.
Yu S, Zhang P, Dong W, Zeng W, Pan C.
europepmc   +5 more sources

High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance. [PDF]

Cell Prolif
In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Huang J, Wang A, Li X, Huang P, Zeng K, Sun L, Li M, Chen Y, Wang J.   +8 more
europepmc   +2 more sources

Leydig Cells: Testicular Side Population Harbors Transplantable Leydig Stem Cells [PDF]

Endocrinology, 2004
Dirk G de Rooij, De Rooij Dirk G
exaly   +5 more sources

Regulation of seminiferous tubule-associated stem Leydig cells in adult rat testes [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2016
Haolin Chen, June Liu, Xiaoheng Li
exaly   +2 more sources

Fetal Leydig cells dedifferentiate and serve as adult Leydig stem cells [PDF]

Development, 2018
ABSTRACT Previous studies have established that fetal Leydig cells (FLCs) and adult Leydig cells (ALCs) show distinct functional characteristics. However, the lineage relationship between FLCs and ALCs has not been clarified yet. Here, we reveal that a subset of FLCs dedifferentiate at fetal stages to give rise to ALCs at the pubertal ...
Yuichi Shima, Kanako Miyabayashi, Tetsuya Sato, Mikita Suyama, Yasuyuki Ohkawa, Masao Doi, Hitoshi Okamura, Kentaro Suzuki   +7 more
openaire   +2 more sources

Identification, Proliferation, and Differentiation of Adult Leydig Stem Cells [PDF]

Endocrinology, 2012
Leydig cells, the testosterone-producing cells of the adult testis, rarely turn over. However, their elimination with ethane dimethanesulfonate (EDS) is followed by the appearance of new, fully functional adult Leydig cells. The cells that give rise to the new Leydig cells have not been well characterized, and little is known about the mechanism by ...
Erin, Stanley, Chieh-Yin, Lin, Shiying, Jin, June, Liu, Chantal M, Sottas, Renshan, Ge, Barry R, Zirkin, Haolin, Chen   +7 more
openaire   +2 more sources

Effects of Midazolam on the Development of Adult Leydig Cells From Stem Cells In Vitro [PDF]

Frontiers in Endocrinology, 2021
BackgroundMidazolam is a neurological drug with diverse functions, including sedation, hypnosis, decreased anxiety, anterograde amnesia, brain-mediated muscle relaxation, and anticonvulsant activity. Since it is frequently used in children and adolescents for extended periods of time, there is a risk that it may affect their pubertal development. Here,
Xingyi Zhao, Minpeng Ji, Xin Wen, Dan Chen, Fu Huang, Xiaoju Guan, Xiaoju Guan, Jing Tian, Jing Tian, Jiajia Xie, Jingjing Shao, Jiexia Wang, Luoqi Huang, Han Lin, Leping Ye, Haolin Chen, Haolin Chen, Haolin Chen   +17 more
openaire   +3 more sources

Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction [PDF]

Cell Research, 2014
The ability to identify and isolate lineage-specific stem cells from adult tissues could facilitate cell replacement therapy. Leydig cells (LCs) are the primary source of androgen in the mammalian testis, and the prospective identification of stem Leydig cells (SLCs) may offer new opportunities for treating testosterone deficiency.
Jiang, Mei Hua, Cai, Bing, Tuo, Ying, Wang, Jiancheng, Zang, Zhi Jun, Tu, Xiang'an, Gao, Yong, Su, Zhijian, Li, Weiqiang, Li, Guilan, Zhang, Min, Jiao, Jianwei, Wan, Zi, Deng, Chunhua, Lahn, Bruce T, Xiang, Andy Peng   +15 more
openaire   +2 more sources

Aldosterone Blocks Rat Stem Leydig Cell Development In Vitro [PDF]

Frontiers in Endocrinology, 2018
Aldosterone (ALDO) is a primary endogenous mineralocorticoid, appearing as the main hormone controlling sodium and water homeostasis. Its emerging role in the development of many organs has gained interest over the past few years. In the testis, Leydig cells contain mineralocorticoid receptors and ALDO stimulates androgen synthesis via the ...
Jingwei Zhang, Bisheng Huang, Guanghui Hu, Xiangcheng Zhan, Tiancheng Xie, Saiyang Li, Xiaolu Zhang, Huitao Li, Ren-Shan Ge, Yunfei Xu   +9 more
openaire   +3 more sources