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Morinda officinalis polysaccharides activate the SIRT1/PGC-1α pathway to reduce oxidative damage in Leydig TM3 cells. [PDF]
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NGF induces adult stem Leydig cells to proliferate and differentiate during Leydig cell regeneration
Biochemical and Biophysical Research Communications, 2013Nerve growth factor (NGF) has been reported to be involved in male reproductive physiology. However, few reports have described the activity of NGF during Leydig cell development. The objective of the present study was to examine the role of NGF during stem-Leydig-cell (SLC) regeneration.
Qi Xiang, Ren-Shan Ge, Yadong Huang
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Molecular and Cellular Endocrinology, 2021
Peritubular stem Leydig cells (SLCs) have been identified from rat testicular seminiferous tubules. However, no stem cells for peritubular myoid cells have been reported in the adult testis so far. In the present study, we tested the hypothesis that the peritubular SLCs are multipotent and able to form either Leydig or myoid cells.
Haolin Chen, Ren-Shan Ge, Minpeng Ji
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Peritubular stem Leydig cells (SLCs) have been identified from rat testicular seminiferous tubules. However, no stem cells for peritubular myoid cells have been reported in the adult testis so far. In the present study, we tested the hypothesis that the peritubular SLCs are multipotent and able to form either Leydig or myoid cells.
Haolin Chen, Ren-Shan Ge, Minpeng Ji
exaly +3 more sources
Interleukin 6 inhibits the differentiation of rat stem Leydig cells
Molecular and Cellular Endocrinology, 2018Inflammation causes male hypogonadism. Several inflammatory cytokines, including interleukin 6 (IL-6), are released into the blood and may suppress Leydig cell development. The objective of the present study was to investigate whether IL-6 affected the proliferation and differentiation of rat stem Leydig cells. Leydig cell-depleted rat testis (in vivo)
Ren-Shan Ge, Xiaoheng Li, Xianwu Chen
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Characterization and differentiation of CD51 Stem Leydig cells in adult mouse testes
Molecular and Cellular Endocrinology, 2019It was reported previously that adult mouse stem Leydig cells (SLCs) express CD51 (integrin α-chain V). However, it is still unclear whether all CD51+ cells are SLCs. In the present study, we found that CD51+ cells can be classified into two sub-groups, a weakly-staining group (CD51+) and a strongly-staining group (CD51++).
Haolin Chen +2 more
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Insights into the Regulation on Proliferation and Differentiation of Stem Leydig Cells
Stem Cell Reviews and Reports, 2021Male hypogonadism is a clinical syndrome caused by testosterone deficiency. Hypogonadism can be caused by testicular disease (primary hypogonadism) or hypothalamic-pituitary dysfunction (secondary hypogonadism). The present strategy for treating hypogonadism is the administration of exogenous testosterone. But exogenous testosterone is reported to have
Zhuo-jie Liu +3 more
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Leydig stem cells and future therapies for hypogonadism
Current Opinion in Endocrinology, Diabetes & Obesity, 2020Purpose of review In this review, we outline the most recent advances in the development of Leydig stem cells (LSCs) and summarize the current and upcoming treatments for hypogonadism. Recent findings In-vitro and in-vivo studies show that inducing stem cells to differentiate into ...
Justin K, Achua +2 more
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The neuroendocrine Leydig cells and their stem cell progenitors, the pericytes.
Advances in anatomy, embryology, and cell biology, 2009The Leydig cells of the testis represent the main source of androgens. The idea of Leydig cells as endocrine cells has been the leading characteristic of this interesting cell population till now. Our studies of the last 2 decades allowed us to reveal a new important feature of Leydig cells that is their obvious similarity with structures of the ...
Michail S, Davidoff +3 more
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Effects of perfluorooctanoic acid on stem Leydig cell functions in the rat
Environmental Pollution, 2019Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic (PFOS) are two perfluorinated chemical products widely existing in the environment. Evidence suggested that PFOA might relate to male reproductive dysfunction in rats and humans. PFOA exposure inhibited the function of Leydig cells.
Hemin, Lu +8 more
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