Results 141 to 150 of about 4,949,444 (161)

Perfluorododecanoic acid delays Leydig cell regeneration from stem cells in adult rats

Food and Chemical Toxicology, 2021
Perfluorododecanoic acid (PFDoA) is an endocrine-damaging compound in contaminated food and water. However, the potential role and underlying mechanism of PFDoA in Leydig cell regeneration from stem Leydig cells remain unclear. The current study aims to investigate the effect of PFDoA on the regeneration of Leydig cells in the testis of rats treated ...
Huitao Li, Zina Wen, Chaobo Ni, Xianwu Chen, Yong Cheng, Yuxin Liu, Xiaoheng Li, Qiqi Zhu, Ren-Shan Ge   +8 more
openaire   +2 more sources

[Progress in the study of stem Leydig cells].

Zhonghua nan ke xue = National journal of andrology, 2007
Leydig cells are the primary source of testosterone. As is true for all specialized cells, Leydig cells originally arise from primitive undifferentiated stem cells, stem Leydig cells (SLCs). The huge potential of SLCs is to be used therapeutically to restore testosterone levels in males with androgen deficiency due to diverse causes.
Si-Xiao, Zhang, Qiang, Dong
openaire   +1 more source

Establishment of a stem Leydig cell line capable of 11-ketotestosterone production

Reproduction, Fertility and Development, 2020
The deficiency or insufficiency of androgen can trigger a range of reproductive diseases as well as other symptoms. Stem Leydig cells (SLCs) are critical for the formation and maintenance of a functional androgen-producing cell (Leydig cell, LC) population throughout adult male life. However, to date, our knowledge about SLCs is poor.
Qin Huang, Zhuo Yang, Jie Wang, Yubing Luo, Changle Zhao, Minghui Li, Hesheng Xiao, Wenjing Tao, Deshou Wang, Jing Wei   +9 more
openaire   +2 more sources

Origin and regulation of stem Leydig cells in the adult testis

Current Opinion in Endocrine and Metabolic Research, 2019
Abstract Testosterone, produced by testicular Leydig cells, is essential for the development of the male reproductive system and the maintenance of male reproductive function throughout life. Testosterone produced by the fetal Leydig cells is critical for the differentiation of the male reproductive system and for the masculinization of the fetal ...
Panpan Chen, Xingxing Zhao, Xiaoju Guan, Haolin Chen   +3 more
openaire   +1 more source

Stem Leydig cells: Current research and future prospects of regenerative medicine of male reproductive health

Seminars in Cell and Developmental Biology, 2022
Ren-Shan Ge, Zina Wen, Xiaoheng Li
exaly  

Epidermal growth factor regulates the development of stem and progenitor Leydig cells in rats

Journal of Cellular and Molecular Medicine, 2020
Qiqi Zhu, Ren-Shan Ge, Yadong Huang
exaly  

Method of committed differentiation of human induced pluripotent stem cells into Leydig cells and application of Leydig cells

2021
XIANG PENG, JIANG MEI HUA, LI WEIQIANG
openaire   +1 more source

A role of KIT receptor signaling for proliferation and differentiation of rat stem Leydig cells

Molecular and Cellular Endocrinology, 2017
Ren-Shan Ge, Qing-Quan Lian, Xiaoheng Li
exaly  

Stem Leydig Cells in the Adult Testis: Characterization, Regulation and Potential Applications

Endocrine Reviews, 2019
Haolin Chen, Barry R Zirkin
exaly  

Regulation of development of rat stem and progenitor Leydig cells by activin

Andrology, 2017
R -S Ge
exaly