Results 91 to 100 of about 971,458 (301)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

A New General Allometric Biomass Model [PDF]

, 2011
To implement monitoring and assessment of national forest biomass, it is becoming the trend to develop generalized single-tree biomass models suitable for large scale forest biomass estimation.
Shou Zheng Tang, Wei Sheng Zeng
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Molecular Dynamics Simulations of Detonation Instability

, 2008
After making modifications to the Reactive Empirical Bond Order potential for Molecular Dynamics (MD) of Brenner et al. in order to make the model behave in a more conventional manner, we discover that the new model exhibits detonation instability, a ...
Andrew J. Heim, Edward M. Kober, Niels Grønbech-Jensen, Timothy C. Germann, W. Fickett   +4 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

STEM HAADF electron tomography of palladium nanoparticles with complex shapes

Philosophical Magazine Letters, 2009
Palladium nanoparticles, with potential interest for various applications in catalysis, have been studied by Transmission Electron Microscopy (TEM). In order to ascertain the exact morphology of these particles, electron tomography was perfomed in the Scanning TEM, High Angle Annular Dark Field (STEM-HAADF) imaging mode.
Benlekbir, Samir, Epicier, Thierry, Bausach, M., Aouine, M., Berhault, G.   +4 more
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Factors Shaping Female Representation in STEM Career in Nigeria

African Journal of Economics, Politics and Social Studies
The underrepresentation of females in Science, Technology, Engineering, and Mathematics (STEM) disciplines remains a significant concern in many parts of the world and Nigeria is not an exception. This paper investigates the multifaceted factors influencing the representation of females in STEM disciplines within the Nigerian context by drawing upon ...
Chioma Masi Onoshakpor, Chika Judith Abolle-Okoyeagu, Ojotule Onoja, Christie Etukudor   +3 more
openaire   +2 more sources

High-throughput continuous dielectrophoretic separation of neural stem cells. [PDF]

, 2019
We created an integrated microfluidic cell separation system that incorporates hydrophoresis and dielectrophoresis modules to facilitate high-throughput continuous cell separation. The hydrophoresis module consists of a serpentine channel with ridges and
Adams, Tayloria NG, Aghaamoo, Mohammad, Flanagan, Lisa A, Jiang, Alan YL, Lee, Abraham P, Lee, Do-Hyun, Yale, Andrew R   +6 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source