Results 121 to 130 of about 14,677 (287)
Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications
Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff +2 more
wiley +1 more source
Stereodiscrimination of guests in chiral organosilica aerogels studied by ESR spectroscopy
Beilstein Journal of NanotechnologyMacroporous materials containing surfaces with chiral groups are highly relevant for applications in the chromatographic separation of enantiomers. Despite these materials being highly engineered and commercially available, optimization was often done ...
Sebastian Polarz +3 more
doaj +1 more source
Ir-Catalyzed Regio- and Enantio-selective Hydroalkynylation of β,β-Disubstituted Enamides Forming Homopropargyl Amides Bearing β-Quaternary Stereocenter [PDF]
, 2021 Xiaoli Jiang, Shaolin Zhu
openalex +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 16, 25 April 2026.A chemoenzymatic synthesis of (1R,2S)‐metaraminol was developed by combining gold(I)‐catalysed alkyne hydration and stereoselective biotransamination in a sequential one‐pot process. Various phenol protection strategies were considered in oxidation‐reduction sequences, providing access to enantiopure propargylic alcohols as starting materials for ...
Lorena Escot +2 more
wiley +1 more source
Chemistry – A European Journal, Volume 32, Issue 15, 22 April 2026.Recent theoretical efforts to elucidate the origin of enantioselectivity in transition metal‐catalyzed propargylic substitution reactions are highlighted in this review. ABSTRACT In recent years, asymmetric catalytic propargylic substitution reactions have undergone remarkable development, enabling the construction of chiral carbon centers adjacent to ...
Ken Sakata, Yoshiaki Nishibayashi
wiley +1 more source
Evolution of the Total Syntheses of Batzellasides the First Marine Piperidine Iminosugar
Natural Product Communications, 2013 Batzellasides A-C are C -alkylated piperidine iminosugars isolated from a sponge Batzella sp. The first total synthesis of (+)-batzellaside B was achieved by employing a chiral pool approach starting from L-arabinose for the construction of a piperidine ...
Tetsuya Sengoku +3 more
doaj +1 more source
Nickel-catalyzed enantioselective allylic alkylation of lactones and lactams with unactivated allylic alcohols [PDF]
, 2018 The first nickel-catalyzed enantioselective allylic alkylation of lactone and lactam substrates to deliver products bearing an all-carbon quaternary stereocenter is reported.
Bachman, Shoshana +4 more
core +1 more source
Radical Cross Coupling and Enantioselective Protonation through Asymmetric Photoredox Catalysis
Advanced ScienceAn unprecedented enantioselective protonation reaction enabled by photoredox catalytic radical coupling is developed. Under cooperative dicynopyrazine‐derived chromophore (DPZ) as a photosensitizer and a chiral phosphoric acid catalyst, and Hantzsch ...
Manman Kong +6 more
doaj +1 more source