Results 81 to 90 of about 14,677 (287)
Asymmetric Reduction of Unactivated Alkenes
Chemistry – A European Journal, EarlyView.Unactivated alkenes rank among the most inert functional groups in synthesis and their selective reduction remains challenging. This Review charts the evolution from classical metal‐catalyzed hydrogenation to radical hydrogen atom transfer (HAT) and emerging biocatalytic concepts, highlighting how complementary mechanistic strategies, including the ...
Nico D. Fessner +3 more
wiley +1 more source
Crystal structure of O-isopropyl [bis(trimethylsilyl)amino](tert-butylamino)phosphinothioate
Acta Crystallographica Section E: Crystallographic Communications, 2015 [Bis(trimethylsilyl)amino](tert-butylimino)thiophosphorane reacts in benzene with isopropyl alcohol via 1,2-addition of an iPrO–H bond across the P=N bond, resulting in the title compound, C13H35N2OPSSi2. In the molecule, the P atom possesses a distorted
Oleksandr O. Kovalenko +3 more
doaj +1 more source
Bayesian Optimization of Solvent‐Free Thermal Amidation via Reactive Extrusion
Chemistry – A European Journal, EarlyView.Thermal amidation between a carboxylic acid and an amine was successfully conducted in an extruder in the absence of solvent, coupling agent, or catalyst, relying on an adapted Bayesian Optimization protocol. Active pharmaceutical ingredient moclobemide was synthesized on a larger scale, achieving excellent yield and low Process Mass Intensity (PMI ...
Matthieu Lavayssiere +2 more
wiley +1 more source
Green Synthesis and CatalysisA novel approach to α-fluoroamides bearing a C–F quaternary stereocenter is reported herein. With sulfone installed as the activating group, an alkyl group as well as a fluorine atom was introduced successively under mild conditions.
Jieqing Wu +6 more
doaj +1 more source
The total synthesis of D-chalcose and its C-3 epimer
Beilstein Journal of Organic Chemistry, 2013 We completed a new and efficient synthesis of D-chalcose (I) and the first synthesis of its C-3 epimer (I′) in nine steps with overall yields of 23% and 24%, respectively.
Jun Sun +5 more
doaj +1 more source
CHIMIA, 2018 The chiral iron(II) hydride complex [FeH(CNCEt3)(1a)](BF4) (3, 1a is a chiral macrocycle with an (NH)2P2 donor set) catalyzes the base-free transfer hydrogenation (ATH) of prochiral ketones and the hemireduction of benzils to the corresponding ...
Lorena De Luca, Antonio Mezzetti
doaj +1 more source
Organocatalytic stereodivergent synthesis of β,β-disubstituted-α-aminoacids [PDF]
, 2017 In this work, we present an organocatalytic stereodivergent synthesis of β,β-disubstituted-α-aminoacids using arylidene azlactones as starting materials.
Martinelli, Ada
core
Phosphine-Catalyzed Doubly Stereoconvergent γ-Additions of Racemic Heterocycles to Racemic Allenoates: The Catalytic Enantioselective Synthesis of Protected α,α-Disubstituted α-Amino Acid Derivatives [PDF]
, 2015 Methods have recently been developed for the phosphine-catalyzed asymmetric γ-addition of nucleophiles to readily available allenoates and alkynoates to generate useful α,β-unsaturated carbonyl compounds that bear a stereogenic center in either the γ or ...
Fu, Gregory C., Kalek, Marcin
core +5 more sources
A General Strategy for the Synthesis of Jerangolids Enabled by π‐allyl Stille Coupling
Chemistry – A European Journal, EarlyView.A general strategy for the synthesis of jerangolids is established, featuring a late‐stage π‐allyl Stille coupling of two advanced, highly customizable building blocks to form the skipped diene core. The approach provides access to all naturally occurring jerangolids, including jerangolid H, whose configuration is confirmed by NMR analysis.
Janick Schug +2 more
wiley +1 more source
Synthesis of enantiomeric polyhydroxyalkylpyrrolidines from 1,3-dipolar cycloadducts. Evaluation as inhibitors of a β-galactofuranosidase [PDF]
, 2016 Enantiomeric 2,3,4-tris(hydroxyalkyl)-5-phenylpyrrolidines have been synthesized from the major cycloadducts obtained by the 1,3-dipolar cycloaddition of sugar enones with azomethine ylides derived from natural amino acids.
Oliveira Udry, Guillermo Alejandro +3 more
core +2 more sources