Results 91 to 100 of about 58,537 (265)

General Anesthetics: Aspects of Chirality, Pharmacodynamics, and Pharmacokinetics

open access: yesPharmaceuticals
The introduction of general anesthetics in the mid-19th century is considered one of the greatest contributions to medical practice. It was the first time that complicated surgical interventions became feasible, without putting an excessive strain on the
Ružena Čižmáriková   +2 more
doaj   +1 more source

Learning Strategies from Nature's Blueprint to Cyclic Carbonate Synthesis

open access: yesChemSusChem, Volume 18, Issue 6, March 15, 2025.
The development of sustainable synthetic methods for cyclic carbonates draws inspiration from nature, focusing on eco‐friendly processes and renewable resources like CO2 and biomass. This review explore various CO2 activation mechanisms, green chemistry principles, and green catalysts.
Erika Saccullo   +4 more
wiley   +1 more source

Further Insights Into the Metabolism of LGD‐4033 in Human Urine. Part 1. Structure Elucidation of Additional Important Metabolites

open access: yesDrug Testing and Analysis, EarlyView.
Well‐characterized, chemically synthesized molecules related to LGD‐4033 metabolism were used as analytical standards for the analysis of LGD‐4033 post‐administration urine samples. This approach offered further insights into LGD‐4033 metabolism, providing solid experimental proof for the structure of important previously reported metabolites and ...
Yiannis S. Angelis   +5 more
wiley   +1 more source

Ring Formation in Sesquiterpene Synthesis: Biomimetic vs. Non‐Biomimetic Strategies

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
A short review of cyclase enzyme‐mediated ring formation in sesquiterpene biosynthesis is presented as a prelude to six case studies examining the merits and demerits of biomimetic vs. non‐biomimetic strategies for carbocyclisation in the total synthesis of this iconic natural product class.
Bohan Lin, Chen Dai, Alan C. Spivey
wiley   +1 more source

Vanillin production from lignin depolymerization by acidic deep eutectic solvent and its possible mechanism

open access: yesEnvironmental Progress &Sustainable Energy, EarlyView.
Abstract As one of the most abundant renewable resources and complex aromatic polymers, lignin holds great promise for producing monophenolic compounds. However, its depolymerization into valuable monomers is hindered by intricate side reactions. In this study, alkaline lignin was converted into vanillin using nine choline chloride‐based deep eutectic ...
Xiaoyan Chen, Xiaohui Pan, Dongyang Cui
wiley   +1 more source

Computer‐Aided Functional Oligosaccharide Screening and the Regulatory Role in Lipid Metabolism

open access: yesFood Bioengineering, EarlyView.
ABSTRACT This study investigated the lipid‐lowering effects and intervention mechanisms of structurally diverse functional oligosaccharides on non‐alcoholic fatty liver disease (NAFLD). By integrating computational tools such as molecular docking and molecular dynamics simulations (MDS), a comprehensive “in silico‐in vitro‐in vivo” tri‐dimensional ...
Rui Jing   +3 more
wiley   +1 more source

Stereochemistry in Solution of Some Schiff Bases of 1,2-Diamines with two Molecules of beta-Diketones as Obtained from UV Absorption and Circular Dichroism Spectra. [PDF]

open access: bronze, 1969
Erik Larsen   +7 more
openalex   +1 more source

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