Journal of Lipid Research, 2001 We identified a new peroxisomal disorder caused by a deficiency of the enzyme α-methylacyl-coenzyme A (CoA) racemase. Patients with this disorder show elevated plasma levels of pristanic acid and the bile acid intermediates di- and trihydroxycholestanoic
Sacha Ferdinandusse +5 more
doaj
Molecules, 2013 Ecdysteroids, molting hormones of insects, can exert several mild, non-hormonal bioactivities in mammals, including humans. In a previous study, we have found a significant effect of certain derivatives on the ABCB1 transporter mediated multi-drug ...
Ana Martins +8 more
doaj +1 more source
Botrylactone: new interest in an old moleculedreview of its absolute configuration and related compounds [PDF]
, 2010 The absolute configuration of botrylactone, a unique compound with an interesting polyketide lactone skeleton with two oxirane bridges previously isolated from Botrytis cinerea and described as a powerful antibiotic, has been reviewed on the basis of ...
Durán Patrón, Rosa María +4 more
core +2 more sources
Synthesis and conformational analysis of new derivatives of 7-chloro-1,3-dihydro-5-phenyl-2h-1,4-benzodiazepine-2-one [PDF]
Organic Chemistry : An Indian Journal, OCAIJ, 8(8), 2012 [293-298], 2011 1,4-benzodiazepine-2-ones and their derivatives are prominent structures in medicinal chemistry. These biomolecules have wide biological activities and posses therapeutic applications. In this works, we introduce new derivatives of 1,4-benzodiazepine-2-ones which are synthesized using michael addition reaction of 7-chloro- 1,3-dihydro-5-phenyl-2H-1,4 ...
arxiv
General Anesthetics: Aspects of Chirality, Pharmacodynamics, and Pharmacokinetics
PharmaceuticalsThe introduction of general anesthetics in the mid-19th century is considered one of the greatest contributions to medical practice. It was the first time that complicated surgical interventions became feasible, without putting an excessive strain on the
Ružena Čižmáriková +2 more
doaj +1 more source
Mechanism-based Enzyme Inactivators of Phytosterol Biosynthesis
Molecules, 2004 Current progress on the mechanism and substrate recognition by sterol methyl transferase (SMT), the role of mechanism-based inactivators, other inhibitors of SMT action to probe catalysis and phytosterol synthesis is reported.
W. David Nes +8 more
doaj +1 more source
High resolution mass spectrometry in molecular structure and stereochemical studies - Effect of stereochemistry on the fragmentation of epimeric derivatives of azabicycloalkanes [PDF]
High resolution mass spectrometry in studies of stereochemistry effect on fragmentation of epimeric derivatives of ...
Burlingame, A. L. +2 more
core +1 more source
High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]
, 2011 Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Ahmed +54 more
core +1 more source
The Sequence of the Enterococcal Cytolysin Imparts Unusual Lanthionine Stereochemistry
Nature Chemical Biology, 2013 The enterococcal cytolysin is a two-component lantibiotic of unknown structure with hemolytic activity that is important for virulence. We prepared cytolysin by co-expression of each precursor peptide with the synthetase CylM in E.
Weixin Tang, W. A. van der Donk
semanticscholar +1 more source
Enantioselective PCCP Brønsted acid-catalyzed aza-Piancatelli rearrangement. [PDF]
, 2019 An enantioselective aza-Piancatelli rearrangement has been developed using a chiral Brønsted acid based on pentacarboxycyclopentadiene (PCCP). This reaction provides rapid access to valuable chiral 4-amino-2-cyclopentenone building blocks from readily ...
Delgado, Jose M +5 more
core