Results 121 to 130 of about 58,537 (265)

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

ChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo, Geradius Deogratias, James E. Mgaya, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source

Studies on the constituents of Orchidaceous plants. II. Isolation, structures, and stereochemistry of cyclonervilol, cyclohomonervilol, and dihydrocycloeucalenol C-24 epimers, new triterpenes from Nervilia purpurea Schlechter.

, 1985
Tohru Kikuchi, Shigetoshi Kadota, Hisashi Suehara, Takehiko Shima   +3 more
openalex   +2 more sources

GraphReco: Probabilistic Structure Recognition for Chemical Molecules

ChemistryOpen, EarlyView.
Molecule structure images are unfriendly for machine understanding, blocking productivity improvements in chemical data mining, drug discovery, and many other fields. We present a rule‐based probabilistic Optical Chemical Structure Recognition model to explain and tackle the ambiguity challenges in graph assembly.
Haidong Wang, Yuncheng Yu, Jyh‐Charn Liu   +2 more
wiley   +1 more source

Stereochemistry-aware string-based molecular generation. [PDF]

PNAS Nexus
Tom G, Yu E, Yoshikawa N, Jorner K, Aspuru-Guzik A.   +4 more
europepmc   +1 more source

Stereochemistry and catalysis with zirconium complexes [PDF]

, 1991
Gerhard Erker
openalex   +1 more source

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner   +2 more
wiley   +1 more source

Collective Asymmetric Total Syntheses of Musellarins A-E. [PDF]

J Org Chem
Liu Y, Ou Y, Chang V, Yao H, Tong R.
europepmc   +1 more source

Conformational flexibility and absolute stereochemistry of (3R)-3-hydroxy-4-aryl-β-lactams investigated by chiroptical spectroscopies and TD-DFT calculations

, 2011
Daniele Tedesco, Carlo Bertucci, Riccardo Zanasi, Andrea Guerrini   +3 more
openalex   +2 more sources

Enhancing Lipidomics With High‐Resolution Ion Mobility‐Mass Spectrometry

PROTEOMICS, EarlyView.
ABSTRACT Lipids, indispensable yet structurally intricate biomolecules, serve as critical regulators of cellular function and disease progression. Conventional lipidomics, constrained by limited resolution for isomeric and low‐abundance species, has been transformed by ion mobility‐mass spectrometry (IM‐MS).
Gaoyuan Lu, Shuling Xu, Penghsuan Huang, Lingjun Li   +3 more
wiley   +1 more source

The Curious Case of CysE: Diversity and Distribution of Serine Acetyltransferases in Bacteria

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Serine acetyltransferase (CysE) is a member of the left‐handed β‐helix family of acetyltransferases that catalyze the rate limiting step in de novo cysteine biosynthesis. There are two isoforms of CysE that differ in length, with the shorter isoform lacking approximately 76 amino acids at the N‐terminus of the protein from the serine ...
Keely E. A. Oldham, Adele K. Williamson, Emily K. Grout, Joanna L. Hicks   +3 more
wiley   +1 more source