Results 131 to 140 of about 118,878 (273)
Stereochemistry and chiroptic properties of pheophorbides and related compounds [PDF]
, 1973 Scheer, Hugo, Wolf, H.
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Journal of Forensic Sciences, EarlyView.Abstract In the present study, the metabolism of khat (Catha edulis) and pseudoephedrine was compared with the aim of identifying objective criteria that could be used to discriminate between them for forensic and doping‐control purposes. An in vitro study using human liver microsomes and an in vivo study using rat urine were performed under harmonized
Jong Suk Park +6 more
wiley +1 more source
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, EarlyView.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source
Investigating the molecular mechanisms underlying the anti‐CRISPR function of AcrIIA13b protein
The FEBS Journal, EarlyView.Anti‐CRISPR protein AcrIIA13b inhibits CRISPR–Cas9 function by preventing target DNA engagement. The Cas9–sgRNA ribonucleoprotein (RNP) normally recognizes the protospacer adjacent motif (PAM) duplex to initiate DNA cleavage. AcrIIA13b binding to the PAM‐interacting WED–PI domain blocks this recognition, leaving the target DNA intact.
So Yeon Lee, Hyun Ho Park
wiley +1 more source
Drivers of strigolactone diversity: P450s in strigolactone biosynthesis
Journal of Integrative Plant Biology, EarlyView.This review summarizes the discovery and functional identification of cytochrome P450 in strigolactone biosynthesis, classifies and summarizes the members discovered so far, clarifies their biological significance, discusses the technology of strigolactone synthesis research, and finally describes some problems in strigolactone research and potential ...
Changbin Niu +2 more
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Plant Biotechnology Journal, EarlyView.ABSTRACT Iridoids constitute a prominent class of plant‐specialised metabolites, with carbocyclic iridoids (e.g., geniposide) and secoiridoids (e.g., loganin) diverging early in their biosynthetic pathways. This divergence is marked by substrate‐specific carboxyl methyltransferases—GjGAMT and CrLAMT—that catalyse the decisive methylation step in ...
Li Li +7 more
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Stereochemistry of Two Hydroxybiflavanonols from Garcinia cola Nuts [PDF]
, 1987 Fischer, R., Madubunyi, I., Scheer, Hugo
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Synthesis of (E)‐β‐SF5‐Styrenes via a Heck Reaction of in situ Generated Vinylsulfur Pentafluoride†
Chinese Journal of Chemistry, Volume 44, Issue 11, Page 1823-1827, 1 June 2026.A Heck cross‐coupling reaction between aryl(hetero)iodides and in situ generated vinylsulfur pentafluoride is reported. This reaction provides β‐SF5‐styrenes in one‐step as a single (E)‐stereoisomer and tolerates a broad range of functional groups. Comprehensive Summary The synthesis of (E)‐(1‐alken‐1‐yl)pentafluoro‐λ6‐sulfanes, a valuable class of ...
Nicolas DeGrâce +1 more
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