Results 151 to 160 of about 118,878 (273)

ChemBang: Expanding the Chemical Space Around Small Molecules

Molecular Informatics, Volume 45, Issue 5, May 2026.
Schematic diagram of the underlying concepts behind ChemBang and the molecular generation process from a seed molecular structure by applying the three main categories of chemical transformations, namely, interchange of small substituents, replacement of ring systems, and scaffold enlargement by additional ring systems.
Diana Montes‐Grajales, Luca Menestrina, Ricard Garcia‐Serna, Jordi Mestres   +3 more
wiley   +1 more source

Stereoselective Total Synthesis of (+)-Giganin and Its C10 Epimer by Using Late-Stage LithiationBorylation Methodology [PDF]

, 2013
Alali, Bandur, Beckmann, Besong, Blakemore, Crimmins, Curran, Davoli, De Luca, Dearden, Debré, Dixon, Donohoe, Donohoe, Duret, Duval, Elford, Esposti, Fang, Furuhata, Gao, Gralla, Griggs, Hattori, Hiscox, Hoppe, Hu, Hu, Huh, Kolb, Larouche-Gauthier, Liu, Marshall, Matteson, Matteson, Matteson, Matteson, Matteson, McLaughlin, Miyoshi, Oasa, Oberlies, Okun, Persich, Sohn, Strand, Strand, Strand, Stymiest, Takahashi, Takahashi, Takahashi, White, Yamamoto, Ye, Yu   +55 more
core   +3 more sources

Insights Into Bifenthrin Stereoisomers and Their Regulatory Implications

ChemistryOpen, Volume 15, Issue 5, May 2026.
Bifenthrin is a pyrethroid insecticide with two stereogenic centers, generating four stereoisomers with distinct physicochemical and electronic properties. A combined crystallographic and density functional theory study, supported by Hirshfeld surface, quantum theory of atoms in molecules, natural bond orbital, and reactivity descriptor analyses ...
Nayara C. M. Santos, Nayara D. Coutinho, Vitor S. Duarte, Anderson Catao, Antônio S. N. Aguiar, Lucas D. Dias, James O. Fajemiroye, Hamilton B. Napolitano   +7 more
wiley   +1 more source

An Unusual Ring Pattern in the Rosβ Lanthipeptide of the Two-Component Lantibiotic Roseocin. [PDF]

J Nat Prod
Desormeaux EK, Zhu L, Luo Y, Sareen D, van der Donk WA.   +4 more
europepmc   +1 more source

Tetrameric hotdog‐fold structure and catalytic mechanism of the SaPaaI thioesterase from Staphylococcus aureus

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Acyl‐CoA thioesterases hydrolyse thioester bonds to release free fatty acyl chains and coenzyme A (CoA), thereby regulating lipid metabolism, signaling, and membrane homeostasis. Here, we present the structural and functional characterization of the Paal‐like thioesterase SAV0944 (SaPaaI) from Staphylococcus aureus.
Yogesh Khandokar, Parul Srivastava, Renate H. M. Schwab, Ashish Sethi, Naveen Vankadari, Jade K. Forwood   +5 more
wiley   +1 more source

Total Synthesis and Complete Stereochemical Assignment of the Marine Bromotriterpenoid (+)-Callicladol through a Combined Approach Using Model Syntheses and Nuclear Magnetic Resonance Calculations. [PDF]

J Am Chem Soc
Nishikibe K, Kumagai M, Nishikawa K, Tsuruta T, Hiura T, Morimoto Y.   +5 more
europepmc   +1 more source

Substrate selectivity of human histidine methyltransferase METTL9

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Methylation of histidine residues in zinc transporters by histidine methyltransferase METTL9 plays an important role in modulating their metal‐binding properties. Here, we report synthetic, enzymatic, and computational studies on human METTL9‐catalyzed Nπ‐methylation of His375 in zinc transporter SLC39A5‐derived peptides in which the histidine
Sadaf Ahmad, Laust Moesgaard, Christian W. Tornøe, Paulina Emmel, Klaudia Slusarczyk, Jakub Drozak, Jacob Kongsted, Jasmin Mecinović   +7 more
wiley   +1 more source

Stereochemistry-aware string-based molecular generation. [PDF]

PNAS Nexus
Tom G, Yu E, Yoshikawa N, Jorner K, Aspuru-Guzik A.   +4 more
europepmc   +1 more source

The Curious Case of CysE: Diversity and Distribution of Serine Acetyltransferases in Bacteria

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 5, Page 1092-1103, May 2026.
ABSTRACT Serine acetyltransferase (CysE) is a member of the left‐handed β‐helix family of acetyltransferases that catalyze the rate limiting step in de novo cysteine biosynthesis. There are two isoforms of CysE that differ in length, with the shorter isoform lacking approximately 76 amino acids at the N‐terminus of the protein from the serine ...
Keely E. A. Oldham, Adele K. Williamson, Emily K. Grout, Joanna L. Hicks   +3 more
wiley   +1 more source

Design, Scalable Synthesis, and Characterization of Poly(Oligourethane Methacrylate)s Bottlebrushes with Discrete, Sequence-Defined, and Stereocontrolled Side-Chains. [PDF]

Macromolecules
Mbizana S, Rutkowski J, Zwoliński K, Castellanos E, Pietrasik J, Szweda R.   +5 more
europepmc   +1 more source