Results 151 to 160 of about 63,316 (301)

Stability studies of cynaropicrin–major sesquiterpene lactone of Cynara cardunculus leaves

Pest Management Science, EarlyView.
This study investigated its stability under high temperature and pH, mimicking agronomic extremes and under soil context. Bioassays demonstrated that degradation products exhibited higher phytotoxic activity than cynaropicrin and deacylcynaropicrin. This is the first study about cynaropicrin's stability, characterizing degradation products, and their ...
Daniela Rosa, Carlos Rial, José MG Molinillo, Alejandro Sampalo, Rosa M Varela, Francisco A Macías, Maria F Duarte   +6 more
wiley   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Helical reconstruction of amyloids in cryoSPARC

Acta Crystallographica Section F, EarlyView.
We present practical guidelines for helical reconstruction of amyloid filaments in cryoSPARC, benchmarked against publicly available datasets. Our analysis defines current capabilities and limitations, and outlines optimization strategies to enable high‐throughput structural studies and therapeutic discovery.Amyloid‐mediated proteotoxicity underlies ...
Jan-Hannes Schaefer, Robert T. O'Neill, Joseph P. Donnelly, Evan T. Powers, Jeffery W. Kelly, Gabriel C. Lander   +5 more
wiley   +1 more source

Assigning the stereochemistry of natural products by machine learning. [PDF]

J Cheminform
Orsi M, Reymond JL.
europepmc   +1 more source

Structure of the Arabidopsis receptor kinase SRF6 ectodomain determined from crystals obtained using the LRR crystallization screen

Acta Crystallographica Section D, EarlyView.
A crystallization screen that has enabled the structural analysis of various extracellular domains of plant membrane receptor kinases is described together with the structure of the LRR domain of the receptor SRF6.Plant‐specific membrane receptor kinases with structurally diverse extracellular domains regulate key processes in plant growth, development,
Alberto Caregnato, Ulrich Hohmann, Michael Hothorn   +2 more
wiley   +1 more source

In vitro and in vivo metabolism profiles of cathinone and pseudoephedrine: Discrimination between khat and pseudoephedrine uses

Journal of Forensic Sciences, EarlyView.
Abstract In the present study, the metabolism of khat (Catha edulis) and pseudoephedrine was compared with the aim of identifying objective criteria that could be used to discriminate between them for forensic and doping‐control purposes. An in vitro study using human liver microsomes and an in vivo study using rat urine were performed under harmonized
Jong Suk Park, Jun Sang Yu, Yejin Kim, Hee Seung Kim, Jae Chul Cheong, Jin Young Kim, Hye Hyun Yoo   +6 more
wiley   +1 more source

London Dispersion Governs Stereochemistry, Stability, and Self-Sorting in a System of M₄L₄ Cages. [PDF]

J Am Chem Soc
Massad I, Dobson JTF, Teeuwen PCP, Ronson TK, Nitschke JR.   +4 more
europepmc   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Physical Implausibility of Carbohydrate Ligands in Results of Deep Learning-Based Cofolding Methods. [PDF]

J Chem Inf Model
Luthfi M, Simpkin AJ, Elliott LG, Sompornpisut P, Rigden DJ.   +4 more
europepmc   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source