Results 161 to 170 of about 118,878 (273)

An Unusual Stereochemical Outcome in the Oxidatively Induced Reductive Elimination of (Pentenediyl)iron Complexes [PDF]

, 1997
Donaldson, William, Yun, Young K.
core   +1 more source

Structures of variants of Escherichia coli flavodiiron‐type nitric oxide reductase reveal changes in the di‐iron site

Acta Crystallographica Section D, Volume 82, Issue 5, Page 457-470, May 2026.
Flavodiiron proteins (FDPs) are di‐iron enzymes that reduce NO and/or O2 with distinct substrate selectivity. We have produced E. coli FDP variants targeting second coordination‐sphere residues and determined their structures. Although the kinetics remained unchanged, the E.
Patrícia T. Borges, Filipe Folgosa, Maria C. Martins, Guillaume Gotthard, Peter van der Linden, Philippe Carpentier, Miguel Teixeira, Carlos Frazão, Célia V. Romão   +8 more
wiley   +1 more source

Collective Asymmetric Total Syntheses of Musellarins A-E. [PDF]

J Org Chem
Liu Y, Ou Y, Chang V, Yao H, Tong R.
europepmc   +1 more source

Syntheses and stereochemistry of hydroxy-substituted alicyclic β-amino acid derivatives [PDF]

, 2010
Benedek Gabriella
core  

Rewiring Steroidal Metabolic Pathways for Diosgenin Production in Solanum nigrum

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3032-3047, May 2026.
ABSTRACT Diosgenin is a key starting material for the synthesis of steroidal drugs, such as corticosteroids and sex hormones. While the primary commercial source of diosgenin is the tubers of Dioscorea spp., identifying alternative plant hosts capable of diosgenin biosynthesis could enhance its production.
Jongbu Lim, Keunhwa Kim, Jung Heo, Seung Mo Seo, Sungjun Choung, Hyeonjin Kim, Yuri Choi, Kyungsun Park, Hyejung Yun, Dongha Kim, Eun Song Lee, Junwoo Lee, Smita Mirsyad Warsadiharja, Saet Buyl Lee, Sunkyu Han, Soon Ju Park, Sang‐Gyu Kim   +16 more
wiley   +1 more source

Second‐Generation Crystalline Sponges Enabling Consistent Structure Analysis Under Standardized Conditions for Diverse Molecules

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
The second‐generation crystalline sponge method allows structurally diverse molecular guests to crystallize under standardized crystallization conditions. The key is the predominant packing type of cages and anions in crystals. ABSTRACT Crystallization is typically highly sensitive to even minor structural differences in target molecules.
Wei He, Hiroki Takezawa, Makoto Fujita
wiley   +2 more sources

Co-Translational Incorporation of <i>(R)</i>- and <i>(S)</i>-β²-Hydroxy Acids <i>In Vitro</i>: A Structural and Biochemical Study on the <i>E. coli</i> Ribosome. [PDF]

J Am Chem Soc
Majumdar C, Kent AD, Hamlish NX, Zhu C, Fitzgerald KA, Cate JHD, Schepartz A.   +6 more
europepmc   +1 more source

Do carbenium ion additions toward alkenes proceed via .pi. complexes? A stereochemical investigation [PDF]

, 1986
Mayr, Herbert, Pock, Rudolf, Rubow, Monika, Wilhelm, Eberhard   +3 more
core   +1 more source

Design, Synthesis, and Evaluation of New Polyhydroxylated Bis‐Chalcones as Potential COX‐2 Selective Inhibitors

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Novel polyhydroxylated bis‐chalcones were successfully synthesized and demonstrated COX‐2 selective inhibition. The most potent and selective inhibitor exhibited a mixed‐type inhibition mechanism with COX‐2. Its additional bulk preferentially blocked the access to the active pocket of COX‐1 rather than COX‐2. Selective inhibition of COX‐2 is considered
Rui Pereira, Alberto N. Araújo, Daniela Ribeiro, Ismael Rufino, Nuno Martinho, Rita C. Guedes, Vera L. M. Silva, Eduarda Fernandes   +7 more
wiley   +1 more source

Total Synthesis of the Spirocyclic Bis‐Indole Alkaloid (−)‐Owerreine via a [4+2] Annulation

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
The total synthesis of the bis‐indole alkaloid (−)‐owerreine has been accomplished by a diastereoselective [4+2] annulation between an enamine and an α,β−unsaturated indolenine precursor to form the 3‐spirocyclic tetrahydropyridine linkage of the natural product. DFT calculations allow an understanding of the mechanism of the key annulation.
Elisa Coll, Vincent Gandon, Cyrille Kouklovsky, Laurent Evanno, Guillaume Vincent   +4 more
wiley   +2 more sources