Results 161 to 170 of about 40,087 (250)

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Asymmetric Total Synthesis and Structure Revision of (+)-Mangicol D. [PDF]

J Am Chem Soc
Xie Y, Wang Y, Zhu Z, Ning S, Maimone TJ.   +4 more
europepmc   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

The pivotal role of β-lactone stereochemistry in the development of SARS-CoV-2 M^pro inhibitors. [PDF]

Protein Sci
Świderek K, Moliner V.
europepmc   +1 more source

Cryo‐EM structure of GH43 β‐Xylosidase from Enterobacter cloacae provides insights into substrate specificity and the role of an auxiliary domain in enzymatic activity

The FEBS Journal, EarlyView.
Xylan, the second most abundant plant cell wall polysaccharide, is degraded by β‐xylanases and β‐xylosidases. Here, we present the 2.65 Å cryo‐EM structure of Enterobacter cloacae β‐xylosidase (EcXyl43, GH43) and the 2.4 Å X‐ray structure of its inactive F507A mutant.
Lorenzo Briganti, Andre Schutzer Godoy, Caio Cesar Mello Capetti, Rafaela Sachetto Fernandes, Vanessa O. A. Pellegrini, Ornella M. Ontañon, Eleonora Campos, Rodrigo V. Portugal, Igor Polikarpov   +8 more
wiley   +1 more source

Generation of Polysubstituted Tetrahydrofurans via Urea-Enabled, Pd-Catalyzed Olefin Heteroannulation. [PDF]

Org Lett
O'Neil ST, Monteferrante OE, Stanley BR, Paradine SM.   +3 more
europepmc   +1 more source

Benign by design: A paradigm shift in cosmetic ingredient development

International Journal of Cosmetic Science, EarlyView.
Benign by design strategies enable the creation of biodegradable cosmetic ingredients, reducing environmental persistence while maintaining the intended biological activity. This work compiles design rules and tools to guide the development of more sustainable molecules for the cosmetics industry.
Sandra Mota, Klaus Kümmerer, Isabel Martins de Almeida, Emília Sousa   +3 more
wiley   +1 more source

Installing Axial Chirality by Atroposelective C(sp³)-H Bond Oxidation. [PDF]

J Am Chem Soc
Borrell M, Galeotti M, Vicens L, Mintz T, Call A, Pappo D, Costas M.   +6 more
europepmc   +1 more source

Geometrical isomerization of hydroxycinnamic acid under UV‐light: Structural plasticity as a driver of metabolite complexity

Photochemistry and Photobiology, EarlyView.
UV irradiation drives metabolite complexity through photoisomerization of hydroxycinnamic acid‐containing compounds in plants. The olefin functional group of hydroxycinnamic acid enables structural plasticity through trans/cis isomerization. Multiple chromophores within a molecule can amplify UV‐induced transformations.
Mailane Rose Sekgobela, Lutendo Michael Mathomu, Nakisani Babra Moyo, Rudzani Nemadzhilili, Mwadham Mwombeki Kabanda, Ntakadzeni Edwin Madala   +5 more
wiley   +1 more source

Synthesis and Structural Confirmation of Secalosides A and B. [PDF]

J Am Chem Soc
Nam Y, Tam AT, Reynolds TE, Rojas DN, Brekan JA, Sil S, Scheidt KA.   +6 more
europepmc   +1 more source