Results 181 to 190 of about 40,087 (250)

Assessing Vancomycin‐Formyl Peptide Conjugate Binding to the Surface of Resistant Staphylococcus aureus via Flow Cytometry

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
A flow cytometry technique was developed to measure the binding of vancomycin‐formyl peptide conjugates to the surface of resistant Staphylococcus aureus. Binding results indicate that the labelling site of the vancomycin targeting element has a major effect on binding to the bacterial cell wall, which correlates with reduced antibiotic activity ...
Winfrey P. Y. Hoo, Jemma Gullick, Ryan F. Leung, Alex J. Fulcher, Rachel W. Cass, Julien Tailhades, Anton Y. Peleg, Jennifer A. E. Payne, Meredith O’Keeffe, Max J. Cryle   +9 more
wiley   +1 more source

Foundation and Multimodal Models for Drug Discovery in Molecular Informatics: Principles, Evaluation, and Practical Guidance. [PDF]

Mol Inform
Pastore EP, De Rango F.
europepmc   +1 more source

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

Engineering Polyketide Stereocenters with Ketoreductase Domain Exchanges. [PDF]

J Am Chem Soc
Keiser LS, Gatenil PP, Zhu Y, Deng K, Waldburger L, Gin JW, Chen Y, Baidoo EEK, Petzold CJ, Lanclos N, Northen TR, Englund E, Keasling JD.   +12 more
europepmc   +1 more source

Chemical Optimization of Temporin A–L Peptides: From Native Isoforms to Enhanced Antimicrobial Analogs

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Temporins, among antimicrobial peptides, are short frog‐derived molecules with potent antibacterial activity. This review highlights chemical optimization strategies applied to temporins A–L, showing how sequence tuning modulates structure, stability, and selectivity, enabling improved activity against resistant pathogens.
Ida Boccino, Paolo Grieco, Francesco Merlino   +2 more
wiley   +1 more source

Improving Stereochemical Limitations in Protein-Ligand Complex Structure Prediction. [PDF]

ACS Omega
Ishitani R, Moriwaki Y.
europepmc   +1 more source

HetCA/STOCSY‐Guided Dereplication of Artemisia arborescens Reveals Furofuran Lignans with Antileishmanial Effects

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Bioactive metabolites can remain hidden in negligible activity extracts. A statistical spectroscopy–driven dereplication workflow integrating the HeteroCovariance Approach (HetCA) and Statistical Total Correlation Spectroscopy (STOCSY) prioritized furofuran lignans in Artemisia arborescens, identifying three compounds with moderate antileishmanial ...
Olga Karoutzou, Stavros Beteinakis, Olga Koutsoni, Despina Smirlis, Maria Halabalaki, Leandros Alexios Skaltsounis, Emmanuel Mikros   +6 more
wiley   +1 more source

Stereoselective synthesis of 1'-α-cyano carbocyclic pyrimidine nucleoside analogs <i>via</i> a chelation-controlled 1'-α-hydroxymethylation strategy.

Org Biomol Chem
Biteau NG, Kasthuri M, Patel D, De R, Schinazi RF, Amblard F.   +5 more
europepmc   +1 more source

Stereospecific cross-coupling reactions: Programmed assembly of chiral molecules by reaction of chiral reagents. [PDF]

Sci Adv
Liang H, Zhang X, Morken JP.
europepmc   +1 more source

Radiolysis Derivatives from <i>p</i>-Coumaric Acid via Gamma Irradiation and Their Anti-Inflammatory Activities. [PDF]

Molecules
Han AR, Song HY, Jeong GH, Choi E, Min YJ, Kim SY, Woo SY, Jin CH, Byun EB, Bai HW.   +9 more
europepmc   +1 more source