Results 171 to 180 of about 118,878 (273)

Strong Implications From Small Deviations in Labeling Patterns: The Mechanism of Burkholderia gladioli Pacifigorgiadiene Synthase

open access: yesChemistry – A European Journal, Volume 32, Issue 16, 25 April 2026.
The mechanism of pacifigorgiadiene synthase from Burkholderia gladioli was investigated through isotopic labeling experiments and DFT calculations. The results revealed an unexpected labeling pattern which appeared to be different in the main and the side products, requiring unprecedented mechanistic explanations, including a “break‐flip‐cyclise ...
Zhiyong Yin   +6 more
wiley   +1 more source

Rh‐Catalyzed Chemodivergent Parallel Kinetic Resolution and Desymmetrization of Enynes and Dienynes with Acrylamides

open access: yesAngewandte Chemie, Volume 138, Issue 17, 20 April 2026.
Rh‐catalyzed chemodivergent parallel kinetic resolution of racemic 1,6‐enynes with α‐fluoroacrylamides or mixtures of different acrylamides proceeded via [2+2+2] cycloaddition and C–H alkylation to afford structurally and stereochemically distinct products with high selectivity under mild conditions.
Shintaro Hamada   +5 more
wiley   +2 more sources

Stereoselective Chemoenzymatic Synthesis Metaraminol Involving Gold‐Catalysed Alkyne Hydration and Carbonyl Biotransamination

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 16, 25 April 2026.
A chemoenzymatic synthesis of (1R,2S)‐metaraminol was developed by combining gold(I)‐catalysed alkyne hydration and stereoselective biotransamination in a sequential one‐pot process. Various phenol protection strategies were considered in oxidation‐reduction sequences, providing access to enantiopure propargylic alcohols as starting materials for ...
Lorena Escot   +2 more
wiley   +1 more source

Triptindane‐9,10,11‐triol: Threefold Hydride Transfer from Lithium Aluminum Hydride as the Key Step to C3‐Symmetrically Trifunctionalized Tribenzo[3.3.3]propellanes

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 15, 22 April 2026.
Threefold reduction of 9,10,11‐triptindanetrione with LiAlH4 or NaBH4 yields exclusively the C3‐symmetric triol, suggesting an intracomplex (“rolling”) mechanism. However, use of LiAlH4/LiAlD4 (1 : 1) reveals a preceding hydride exchange. Mechanistic implications are discussed including the reduction of the related diketone.
Thorsten Hackfort   +5 more
wiley   +1 more source

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