Results 171 to 180 of about 118,878 (273)
Asymmetric Total Synthesis and Structure Revision of (+)-Mangicol D. [PDF]
Xie Y +4 more
europepmc +1 more source
The mechanism of pacifigorgiadiene synthase from Burkholderia gladioli was investigated through isotopic labeling experiments and DFT calculations. The results revealed an unexpected labeling pattern which appeared to be different in the main and the side products, requiring unprecedented mechanistic explanations, including a “break‐flip‐cyclise ...
Zhiyong Yin +6 more
wiley +1 more source
Rh‐catalyzed chemodivergent parallel kinetic resolution of racemic 1,6‐enynes with α‐fluoroacrylamides or mixtures of different acrylamides proceeded via [2+2+2] cycloaddition and C–H alkylation to afford structurally and stereochemically distinct products with high selectivity under mild conditions.
Shintaro Hamada +5 more
wiley +2 more sources
Generation of Polysubstituted Tetrahydrofurans via Urea-Enabled, Pd-Catalyzed Olefin Heteroannulation. [PDF]
O'Neil ST +3 more
europepmc +1 more source
A chemoenzymatic synthesis of (1R,2S)‐metaraminol was developed by combining gold(I)‐catalysed alkyne hydration and stereoselective biotransamination in a sequential one‐pot process. Various phenol protection strategies were considered in oxidation‐reduction sequences, providing access to enantiopure propargylic alcohols as starting materials for ...
Lorena Escot +2 more
wiley +1 more source
Threefold reduction of 9,10,11‐triptindanetrione with LiAlH4 or NaBH4 yields exclusively the C3‐symmetric triol, suggesting an intracomplex (“rolling”) mechanism. However, use of LiAlH4/LiAlD4 (1 : 1) reveals a preceding hydride exchange. Mechanistic implications are discussed including the reduction of the related diketone.
Thorsten Hackfort +5 more
wiley +1 more source
An Unexpected Isomerization for the Total Synthesis of Daphnepapytone A. [PDF]
Lubins I, Breit B.
europepmc +1 more source
Data curation in cheminformatics: importance and implementation. [PDF]
Esaki T, Ikeda K.
europepmc +1 more source
Foundation and Multimodal Models for Drug Discovery in Molecular Informatics: Principles, Evaluation, and Practical Guidance. [PDF]
Pastore EP, De Rango F.
europepmc +1 more source

