Results 221 to 230 of about 58,537 (265)

Ribosomal Synthesis of Topologically Defined Thioisoindole‐Bridged Bicyclic Peptides

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
A flexible in vitro translation (FIT) system‐based strategy for ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is developed. The flexizyme substrate Ac‐Ala(NtBA)Sc‐CME is efficiently incorporated into FIT to generate ribosomal peptides bearing N‐terminal Ac‐Ala(NtBA)Sc as the cyclization handle, which after mild deprotection ...
Yue Zhang, Alexander A. Vinogradov, Yin Sun, Hiroaki Suga   +3 more
wiley   +1 more source

Genome Mining-Based Discovery of Pyrano[2,3-<i>c</i>]pyrrole Type Natural Products Possessing Alkyl Side Chain with Branched Methyl Groups. [PDF]

Org Lett
Shi Y, Ozaki T, Morishita Y, Taniguchi T, Sato H, Aoyama Y, Sugawara A, Numata K, Fuse T, Matsuda R, Hosotani K, Fukano H, Hoshino Y, Hirabayashi A, Suzuki M, Yasuda J, Yoshikawa R, Hayashi H, Kodama EN, Shimotai Y, Hamamoto H, Davis RA, Asai T.   +22 more
europepmc   +1 more source

On the Nature of Improper Hydrogen Bonding in RCH2F and RCHF2 Motifs

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
The nature of ‘improper’ hydrogen bonds is explored in FnC─H⋯X systems, such as RCF2H interaction with chloride and water. It is noted that increased fluorination decreases the positive charge density on H but increases it on C, thus these interactions are dominated by electrostatic attraction to C over H.
Bruno A. Piscelli, Michael Bühl, Rodrigo A. Cormanich, David O'Hagan   +3 more
wiley   +1 more source

Bioinspired Synthesis of Twin abeo‐Steroids Bufogargarizins A and B via a Divergent Intramolecular Aldol Addition Reaction

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Twin natural products. This manuscript describes a concise biomimetic synthesis of twin abeo‐steroids bufogargarizins A and B with an unusual [7.5.6.5] and [5.7.6.5] skeletons in 19 steps (LLS). The described synthetic approach features the application of a bioinspired regiodivergent intramolecular aldol addition reaction and a selective singlet oxygen‐
Zoey J. Surma, Volodymyr Hiiuk, Eugene Zviagin, Yaxin Ouyang, Alex Chacko, Fengrui Qu, Paul M. Zimmerman, Pavel Nagorny   +7 more
wiley   +1 more source

Diversifying the triquinazine scaffold of a Janus kinase inhibitor. [PDF]

RSC Med Chem
Mulliri K, Meier K, Feuchter JD, Javor S, Meirelles MA, Reymond JL.   +5 more
europepmc   +1 more source

Correction to: Local Disordered Region Sampling (LDRS) for ensemble modeling of proteins with experimentally undetermined or low confidence prediction segments. [PDF]

Bioinformatics
europepmc   +1 more source

POPPING BALLOONS: A FUN ACTIVITY TO ENGAGE STUDENTS IN REVIEW OF CHEMICAL NOMENCLATURE AND STEREOCHEMISTRY BY USING EDUCATIONAL GAMES AND LOW-COST MATERIALS

José Nunes da Silva, Antônio José Melo Leite, Renner César Silveira Jucá   +2 more
openalex   +1 more source

One-Step Biomimetic Synthesis of the Alkaloids Karachine, Valachine, and Sinometumine E. [PDF]

Org Lett
Fadeev AA, Vanoušková A, Kotora M.
europepmc   +1 more source

Efficient Stereochemical Analysis of Hydroxy Fatty Acids Using PGME and PAME Derivatization. [PDF]

Anal Chem
Um S, Lee J, Kim SH.
europepmc   +1 more source

Schweinfurthins and their analogues are highly selective cellular probes for oxysterol-binding protein (OSBP). [PDF]

RSC Med Chem
Depta L, He N, Madsen ML, Nielsen MLH, Bryce-Rogers HP, Waterworth SC, Neighbors JD, Stockdale DP, Callahan MP, Mente NR, Wiemer DF, Beutler JA, Laraia L.   +12 more
europepmc   +1 more source