Results 141 to 150 of about 13,428 (198)

Transition Metal‐Free Vinylcyclopropanation of Olefins via Carbolithiation Reactions: Synthesis of 3‐Azabicyclo[3.1.0]hexanes

Advanced Synthesis &Catalysis, Volume 368, Issue 17, 1 September 2026.
Readily accessible N‐allyl‐N‐2‐bromoallylamines undergo a tandem lithiation–cyclization cascade to furnish highly substituted 3‐azabicyclo[3.1.0]hexanes. The transformation proceeds without transition metals and delivers products with excellent diastereocontrol across a broad substrate range.
Nuria Cases, Marta Solas, M. Pilar Castroviejo, Samuel Suárez‐Pantiga, Miguel A. Rodríguez, Roberto Sanz   +5 more
wiley   +1 more source

Generation of the Camptothecin Scaffold by a Flavin‐Catalyzed Photooxidative Skeletal Reorganization

Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.
The biosynthetic pathway of the anticancer drug precursor camptothecin involves an enigmatic skeletal reorganization from a 6/5/6 tetrahydro‐β‐carboline to a 6/6/5 pyrroloquinoline ring system. Here, we show that this transformation can be achieved by photooxidation with flavin cofactors, such as flavin mononucleotide (FMN) as catalysts.
Shenyu Liu, Zeliang Zhang, Benedikt Seligmann, Van Hung Bui, Tuan‐Anh Minh Nguyen, Thu‐Thuy T. Dang, Jakob Franke   +6 more
wiley   +2 more sources

Unspecific Peroxygenase-Based Chemo-Enzymatic Synthesis of Amino Alcohols for Pharmaceutical Preparation. [PDF]

Chembiochem
Last S, Gazizova A, Wittmann K, Dietz N, Weissenborn MJ, von Langermann J.   +5 more
europepmc   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Cytochrome P450- and Dehydrogenase-Mediated Regiospecific and Stereoselective Formation of β- and γ-Lactones in Drimane-Type Sesquiterpenoid Biosynthesis. [PDF]

J Am Chem Soc
Wu M, Wu J, Janzen DJ, Yin WB, Li SM.
europepmc   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

Single Amino Acid-Based Control of Fibril Supramolecular Chirality. [PDF]

J Phys Chem Lett
Sitton J, Kurouski D.
europepmc   +1 more source

Synthesis of 3,5‐Diarylated 4‐Cyano‐2‐nitrophenols via Nitro Rearrangement

Asian Journal of Organic Chemistry, Volume 15, Issue 9, September 2026.
A practical synthetic route to 3,5‐diaryl‐4‐cyano‐2‐nitrophenols, a class of unsymmetrically substituted and densely functionalized phenols, is provided. The key transformation is a nitro rearrangement of 4‐cyano‐4‐nitrocyclohexanone derivatives, which were prepared from di(benzylidene)acetones through cyano(nitro)methylation.
Nagatoshi Nishiwaki, Genta Taniguchi, Taisei Yoshikawa, Kento Iwai   +3 more
wiley   +1 more source

A Novel, Robust, and Isocratic HPLC-UV Method for the Comprehensive Determination of Enantiomeric Impurity (R-Isomer) in Niraparib Drug Substance. [PDF]

Chirality
Kondaveti PK, Douglas P, Raghunadh A, Kalyanaraman L.   +3 more
europepmc   +1 more source

Flavouring Group Evaluation 82 Revision 2 (FGE.82Rev2): Consideration of epoxides evaluated by JECFA. [PDF]

EFSA J
EFSA Panel on Food Additives and Flavourings (FAF), Castle L, Andreassen M, Aquilina G, Bastos M, Boon P, Fallico B, FitzGerald R, Frutos Fernández MJ, Grasl-Kraupp B, Gundert-Remy U, Gürtler R, Houdeau E, Kurek M, Louro H, Morales P, Passamonti S, Degen G, Engel KH, Carfí M, Criado A, Dino B, Martino C.   +22 more
europepmc   +1 more source