Results 191 to 200 of about 17,928 (220)

Antihypertensive effects of dilevalol, a stereoisomer of labetalol

open access: diamond, 1985
Kazuki Matsunaga   +2 more
openalex   +1 more source

A Triple‐Catalytic, Fully Biogenic Synthesis of Cyclic Carbonates

open access: yesChemSusChem, Volume 19, Issue 1, January 2026.
A three‐step synthesis of cyclic carbonates from biogenic resources (fatty acids, O2, CO2) is reported. The process operates via a visible light‐mediated hydrocarbon oxidation, with an overall 100% atom‐economy, in the presence of easily accessible catalysts (porphyrin, VO(acac)2, pyridine) but without intermediate work‐up procedures.
Robin Stuhr   +2 more
wiley   +1 more source

Recent Developments in Capillary and Microchip Electroseparations of Peptides (2023–mid 2025)

open access: yesELECTROPHORESIS, Volume 47, Issue 1, Page 106-136, January 2026.
ABSTRACT This review presents a comprehensive overview of the developments and applications of high‐performance capillary and microchip electromigration methods (zone electrophoresis in a free solution or in sieving media, isotachophoresis, isoelectric focusing, affinity electrophoresis, electrokinetic chromatography, and electrochromatography) for ...
Václav Kašička
wiley   +1 more source

Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential

open access: yesFood Frontiers, Volume 7, Issue 1, January 2026.
The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima   +15 more
wiley   +1 more source

Crystallography in school. [PDF]

open access: yesJ Appl Crystallogr
Irmer E.
europepmc   +1 more source

Spirocyclic Diamine Scaffolds for Medicinal Chemistry

open access: yesHelvetica Chimica Acta, Volume 109, Issue 1, January 2026.
Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel   +3 more
wiley   +1 more source

Synthesis of Biphenanthrene Natural Products by Atroposelective Aromatic Ring‐Opening Metathesis

open access: yesHelvetica Chimica Acta, Volume 109, Issue 1, January 2026.
Aromatic ring‐opening metathesis in natural product total synthesis allows for the streamlined stereoselective preparation of atropisomeric biphenanthrenes with an enantioselectivity of >99:1 e.r. ABSTRACT With the unique ability to cleave and form an extensive range of carbon–carbon double and triple bonds, alkene and alkyne metathesis advanced to a ...
Valeriia Hutskalova, Christof Sparr
wiley   +1 more source

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