Results 161 to 170 of about 30,863 (282)

Selective N‐Functionalization of Pyrazoles

European Journal of Organic Chemistry, EarlyView.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek, Matthias Schrader, Christopher J. Teskey   +2 more
wiley   +1 more source

Organocatalytic Enantioselective Addition of Malonates to Cyclic Imines: A Short Total Synthesis of Tetraponerine T-1. [PDF]

Angew Chem Int Ed Engl
Kölblin F, Wennemers H.
europepmc   +1 more source

Base‐Free Nickel‐Catalyzed Three‐Component Coupling of Aldehydes, Butadiene, and Malonate Derivatives: Toward Sustainable Synthesis of Highly Functionalized Molecules

European Journal of Organic Chemistry, EarlyView.
A nickel‐catalyzed three‐component reaction between arylaldehydes, butadiene, and malonates is developed yielding high functionalized homoallylic alcohols in a single step. No additional base is required and the reaction shows broad substrates compatibility with yields up to 96% and an exclusive selectivity toward the linear E‐isomer.
Anthony Saint Pol, Radhouan Maazaoui, Céline Delabre, Laëtitia Chausset‐Boissarie, Maël Penhoat, Isabelle Suisse, Aurélien Béthegnies, Mathieu Sauthier   +7 more
wiley   +1 more source

Biosynthetic mechanism and ecological function of chirality in Solanum steroidal alkaloids. [PDF]

Nat Commun
Gao Y, Song W, Zhang X, Ye W, Lin Y, Ma J, Fu Y, Wang B, Lan W, Xu X, Huang W, Lin C, Baldwin IT, Bento JMS, Xue Z, Li J.   +15 more
europepmc   +1 more source

Synthesis of S‐Linked Glycoconjugates of Monosaccharides and Levoglucosenone Derivatives Through Photoinduced Thiol–Ene Reaction Mediated by 4CzIPN and Its Water Soluble Analog

European Journal of Organic Chemistry, EarlyView.
Visible‐light thiol–ene reaction mediated by 4CzIPN enables access to hydrolytically stable S‐linked glycoconjugates from levoglucosenone‐derived thiols (Y = 91% to quant. d.r. = up to >95:5) and conventional thio‐sugars (Y = 80% to quant. d.r. = up to >95:5).
Lorenzo Poletti, Francesco Riina, Daniele Ragno, Carmela De Risi, Alessandro Massi, Graziano Di Carmine   +5 more
wiley   +1 more source

Beyond the two-conformer model: boat conformers provide stereoselectivity in S_N1-type glycosylations of <i>manno</i>-type donors. [PDF]

Chem Sci
Remmerswaal WA, Hoogers D, Schoenmakers J, Bickelhaupt FM, Hansen T, Codée JDC.   +5 more
europepmc   +1 more source

Unified Approach for the Synthesis of Close Analogues of Reverse‐Prenylated Hexahydropyrrolo Indole Alkaloids

European Journal of Organic Chemistry, EarlyView.
A simple, modular, and unified strategy for the synthesis of reverse‐prenylated hexahydropyrrolo indole alkaloids has been developed. An unusual retrosynthetic disconnection allows for the late introduction of a side chain, which distinguishes many members of this class of natural products.
Daniel Schmelzer, Carina S. Wencke, Christian B. W. Stark   +2 more
wiley   +1 more source

Hydrophobic pocket engineering of arylmalonate decarboxylase expands its substrate scope towards the synthesis of the (<i>R</i>)-enantiomers of sterically hindered carboxylic acids.

Chem Commun (Camb)
van der Pol E, Krammer LM, Eder J, Gross D, Fischer RC, Miyamoto K, Breinbauer R, Kourist R.   +7 more
europepmc   +1 more source

Chiral S(VI) platform unifies selective C-H amination of complex molecules and alkane feedstocks. [PDF]

Science
Trinh TA, Hu DB, Kenny AJ, Warrington EM, Cherempei S, Guzei IA, Schomaker JM.   +6 more
europepmc   +1 more source

Nucleophilic Reactions of Cyclobutenones and the Related 4,4‐Dichlorocyclobutenone Derivatives

European Journal of Organic Chemistry, EarlyView.
Cyclobutenone derivates and their 4,4‐dichloro counterparts have an uninterrupted attention as useful synthons in the synthesis of complex organic molecules. Their nucleophilic reactions remain underexplored. This review brings attention to these reactions, whose outcome is not straightforward.
Sarah J. Wright, Muhluri H. Mthombeni, Songeziwe Ntsimango   +2 more
wiley   +1 more source