Results 141 to 150 of about 30,863 (282)

A biocatalytic platform for the stereoselective synthesis of diverse atropisomeric compounds using engineered metalloenzymes. [PDF]

Sci Adv
Cai X, Cui D, Chu Y, Rui Y, Duan X, Peng Y, Wang Z, Xu J.   +7 more
europepmc   +1 more source

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

Clinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul, Waseem Mujahed, Ibrahim Idries, Maor Wanounou, Meir Bialer, Yoseph Caraco   +5 more
wiley   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis. [PDF]

Angew Chem Int Ed Engl
Okunlola GA, Aleku GA.
europepmc   +1 more source

Learning Strategies from Nature's Blueprint to Cyclic Carbonate Synthesis

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
The development of sustainable synthetic methods for cyclic carbonates draws inspiration from nature, focusing on eco‐friendly processes and renewable resources like CO2 and biomass. This review explore various CO2 activation mechanisms, green chemistry principles, and green catalysts.
Erika Saccullo, Vincenzo Patamia, Chiara Zagni, Antonio Rescifina, Giuseppe Floresta   +4 more
wiley   +1 more source

Intracellular assembly of artificial enzymes for cytoplasmic enantioselective Mannich reactions. [PDF]

Nat Commun
Zhu Z, Hu Q, Wu Y, Wang B, Zhou Z.
europepmc   +1 more source

π‐Extended Silyl Enolates as Emerging Platforms in Radical Chemistry

European Journal of Organic Chemistry, EarlyView.
This review covers the emerging role of π‐extended silyl polyenol ethers in radical chemistry. It highlights their versatile roles as electron‐rich SOMOphiles, silyl radical cation precursors, and nucleophilic partners in radical–polar crossover manifolds, while considering recent advances in photoredox catalysis, electrochemistry, and transition metal‐
Debora Guazzetti, Kelly Bugatti, Claudio Curti, Franca Zanardi   +3 more
wiley   +1 more source

Ireland-Claisen Rearrangement as a Stereocontrolled Bond-Construction Strategy in Natural Product Total Synthesis. [PDF]

ACS Omega
Sakaine G, U̅dris N, Šmits G.
europepmc   +1 more source

Conversion of Alcohols to Alkyl Chlorides Using the Bichloride Ionic Liquid [NEt3Me][Cl(HCl)n]

European Journal of Organic Chemistry, EarlyView.
The ionic liquid [NEt3Me][Cl(HCl)1.61] is presented as a controllable source of HCl for the effective transformation of a broad range of alcohols into alkyl chlorides. The process eliminates the need for continuous handling of HCl gas and enables a recyclable IL‐based catalyst system. The solvent‐free chlorination of alcohols using the bichloride‐based
Justus H. Peter, Piet de Jong, Merlin Kleoff, Gesa H. Dreyhsig, Jan‐H. Dickoff, Mohsen Adeli, Sebastian Riedel, C. Christoph Tzschucke, Rainer Haag   +8 more
wiley   +1 more source

Organocatalytic stereoselective C-H diazenylation of active methylenes with arenediazonium salts. [PDF]

RSC Adv
Aqsa, Din A, Ahmad M, Khan H, Israr M, Osama S, Ullah Q, Saba S, Chen ZS, Ali Shah SA, Ali S.   +10 more
europepmc   +1 more source

Exploiting Biocatalysis for the Scalable Synthesis of Enantiopure γ‐Hydroxynitrile Building Blocks

European Journal of Organic Chemistry, EarlyView.
Screening a panel of (S)‐and (R)‐selective alcohol dehydrogenases identified several biocatalysts for stereoselectively reducing γ‐ketonitriles into γ‐hydroxynitriles. These processes were optimized, delivering the targets in yields up to 88% with e.e.’s up to 99%. Scalability of the methodology was achieved to produce gram quantities of product, which
Benjamin Baumert, Kathryn Yeow, Roi Boris Tchuemmogne Tchuente, Adam Cruise, Christopher Thomas, Thomas Bayer, Uwe T. Bornscheuer, Marcus Baumann   +7 more
wiley   +1 more source