Advances in the Different Synthetic Routes of Fluorinated Hydrazines
The Chemical Record, EarlyView.This review highlights the various routes to the preparation of fluorinated hydrazines, thereby promoting the exploration of innovative methods for the synthesis of new N‐fluorinated hydrazines. Their synthesis mainly involves synthetic routes such as organometallic, organocatalytic, and photocatalytic.
Dimitra Kyrko, Benoît Crousse
wiley +1 more source
Synthesis of an A/B-<i>cis</i>-Fused Cyclopenta[<i>b</i>]fluorene (6/5/6/5) Ring System for Embellicine A via the Eight-Membered Silylene-Tethered IMDA Reaction. [PDF]
Org LettSakai Y +7 more
europepmc +1 more source
Human IDO2 exhibits unique binding affinities distinct to those of human IDO1
The FEBS Journal, EarlyView.Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi +8 more
wiley +1 more source
Stereoselective hydrogen isotope exchange on nicotinamide cofactors through flavoenzyme microscopic reversibility. [PDF]
Chem SciOtun CW +9 more
europepmc +1 more source
S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea
The FEBS Journal, EarlyView.S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels +7 more
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Industrial Chemical Glycan Synthesis (ICGS): Process Intensification of Glycosylations. [PDF]
Chem Bio EngQin C +6 more
europepmc +1 more source
Efficient Enantiomeric Selectivity Separation Via Homochiral Graphene Oxide Membrane
ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 4, July 2026.A new type of chiral graphene oxide (GO) membrane is proposed that exhibits a separation factor of up to 20.1 as well as a preferential enantiomer flux of 4.5 mmol m−2 h−1. Moreover, the only first FPLC‐compatible column has been further developed via stacking these chiral GO membranes.
Junbo Wang +10 more
wiley +1 more source
Stereoselective Ferrier-Type O-Glycosylation Enabled by Difluoromethylated Glycal Donors. [PDF]
Adv Sci (Weinh)Zou Y +5 more
europepmc +1 more source
1,1‐and 1,2‐Diborylalkenes: Preparation and Synthetic Applications
Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.In this review, we highlight recent advances in the synthesis and reactivity of 1,1‐diborylalkenes and 1,2‐diborylalkenes, along with various transformations leading to C‐C, C‐heteroatom, and multicomponent products. By providing a comprehensive and practical resource, this review aims to assist researchers in exploring the synthetic utility of 1,1 and
Jayaram Vankudoth +2 more
wiley +1 more source
Confined Acids Catalyze a Broadly Applicable β-Selective <i>O</i>-Glycosylation. [PDF]
J Am Chem SocLu J +6 more
europepmc +1 more source