Results 201 to 210 of about 30,863 (282)

Stereoselective Generalizations over Diverse Sets of Chiral Acids Enabled by Buried Volume. [PDF]

J Am Chem Soc
Smith AL, Toste FD.
europepmc   +1 more source

Design, synthesis and activity evaluation of tetrahydroisoquinoline‐based programmed cell death ligand 1 inhibitors

Smart Molecules, EarlyView.
Based on a 3D‐quantitative structure‐activity relationship pharmacophore model, structural optimization of Y6 yielded Y7f. Mechanistic studies revealed that Y7f acted as a programmed death receptor 1/programmed cell death ligand 1 (PD‐L1) interaction inhibitor by inducing PD‐L1 dimerization. Y7f restored T‐cell function.
Menglin Yu, Sen Cai, Yanyan Pan, Heshuang Wang, Fengwu Zhang, Aiyu Ma, Shixuan Lv, Xiuhan Guo, Shisheng Wang, Qiling Song, Chunyan Ma, Shuai Wang, Li Zhang, Jian Wang, Qingwei Meng, Yueqing Li   +15 more
wiley   +1 more source

Stereoselective synthesis, VCD study and conformational analysis of C-glycosyl isochromans. [PDF]

Sci Rep
Ahmad N, Homolya Á, Barta RA, Herczeg M, Bényei A, Iurgenson N, Bereczki I, Fedics GM, Mándi A, Kurtán T, Borbás A.   +10 more
europepmc   +1 more source

DFT‐assisted rational design of salan ligands for highly enantioselective Zr–salan‐catalyzed hydroxylation of cyclic β‐keto esters

Smart Molecules, EarlyView.
Guided by DFT calculations, the design of novel C1‐symmetric salan ligands without the involvement of Suzuki coupling was achieved, and the preparation of α‐hydroxy‐β‐ketoesters in 99% yield and 99% ee was realized under low catalyst loading. Abstract In this work, a structurally simple, inexpensive, and readily accessible Zr–salan catalytic system was
Cunfei Ma, Kun Tang, Yuchen Jiang, Hongfei Zhu, Yufeng Wu, Yafeng Xing, Yakun Wang, Qilei Liu, Jian Du, Qingwei Meng   +9 more
wiley   +1 more source

Computational design of generalist cyclopropanases with stereodivergent selectivity. [PDF]

Nat Commun
Shen Z, Siriboe MG, Ren X, Dayananda T, Jenkins JL, Khare SD, Fasan R.   +6 more
europepmc   +1 more source

Modular Synthesis of α‐Quaternary Pyrrolines by Pyridoxal‐Catalyzed Sequential Reactions With Precise Chirality Relay

Transformative Chemistry, EarlyView.
Direct asymmetric α‐C conjugate addition of aminoacetonitrile enabled by carbonyl/iminium double activation, together with subsequent electrophilic functionalization, offers a one‐pot, two‐step modular strategy for synthesizing chiral α‐quaternary pyrrolines with precise chirality relay and high structural diversity.
Xingdie Yang, Pengwei Ji, Liang Liu, Tongyin Chen, Siqi Liu, Wen‐Wen Chen, Baoguo Zhao   +6 more
wiley   +1 more source

Highly regio- and <i>E</i>-stereoselective C[double bond, length as m-dash]C bond transposition catalyzed by tris(benzhydryl) sodium calciate. Proof of synergy: one metal is good, but two are better. [PDF]

Chem Sci
Koshelev IV, Selikhov AN, Cherkasov AV, Aysin RR, Trifonov AA.   +4 more
europepmc   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Rh-Catalyzed Chemodivergent Parallel Kinetic Resolution and Desymmetrization of Enynes and Dienynes with Acrylamides. [PDF]

Angew Chem Int Ed Engl
Hamada S, Jiang J, Sato Y, Yamazaki T, Maeda S, Tanaka K.   +5 more
europepmc   +1 more source

Complex Chemistry of a Chiral Terpyridine Ligand Based on (1R)‐(+)‐Camphor

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
From (1R)‐(+)‐camphor, a chiral terpyridine ligand is accessible in a few steps that coordinates to divalent metal ions of the first and second transition metal row. From structural characterization, the steric repulsion of the two equatorial methyl groups of the tetrahydromethanoquinoline units becomes evident, which causes cyclometalation of the ...
Julia Ehrhard, Marc H. Prosenc, Werner R. Thiel   +2 more
wiley   +1 more source