<i>De novo</i> construction of C-O axial chirality <i>via</i> cobalt-catalyzed atroposelective C-H activation/annulation. [PDF]
Chem SciZhang Y +5 more
europepmc +1 more source
Copper-catalysed dynamic kinetic (4+1) cyclization of 1,3-enynes for atroposelective arylpyrrole synthesis. [PDF]
Nat CommunZhong YJ +10 more
europepmc +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 11, 3 June 2026.A substrate‐dependent, regio‐ and stereocontrolled diversity‐oriented organocatalytic vinylogous Michael addition/cyclization cascade of γ, γ’‐alkylidene indane‐1,3‐diones with enals, using secondary amines as the catalyst, has been developed. A substrate‐dependent, regio‐ and stereo‐controlled diversity‐oriented organocatalytic vinylogous Michael ...
Jen‐Yu Kuan +2 more
wiley +1 more source
A theoretical study on the feasibility of 1,4-Copper migration in the Cu-catalyzed formal hydro(borylmethylsilyl)ation of internal alkynes. [PDF]
Commun ChemLiu S +6 more
europepmc +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 11, 3 June 2026.Herein, an organocatalytic asymmetric synthesis of dihydroquinoline/hydantoin hybrids is described. The synthetic protocol involves a tandem reaction comprising a phosphoric acid–catalyzed initial Povarov dimerization of in situ generated imine/enamine mixtures under tautomeric equilibrium, followed by a Urech–Read reaction of the 1,2‐dihydroquinoline ...
Zuriñe Serna‐Burgos +5 more
wiley +1 more source
Convergent Total Synthesis of 16β‐Hydroxylpseudobufarenogin
Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.We present a novel convergent strategy that integrates Pd/Ag‐promoted Suzuki–Miyaura coupling with Ir‐catalyzed radical‐relay cyclization, enabling the first total synthesis of 16β‐hydroxylpseudobufarenogin. This approach is broadly applicable to the total synthesis of various oxygenated bufadienolides by simply modifying the fragment structures ...
Wataru Shigematsu +3 more
wiley +2 more sources
Palladium-Catalyzed Regio- and Stereoselective C-H Alkynylation of Conjugated Dienols. [PDF]
JACS AuYang MW, Lu HX, Zhang JW, Xu YH.
europepmc +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, Volume 600, Issue 11, Page 1638-1654, June 2026.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Iron-Catalyzed Tunable Double Bond Migration and Geometrical Isomerization in Olefins via a Spin-Accelerated Alkyl Mechanism. [PDF]
Angew Chem Int Ed EnglObeid AH +3 more
europepmc +1 more source
Aggregate, Volume 7, Issue 6, June 2026.This review surveys eukaryotic cilia as putative quantum‐enabled sensory and regulatory centers. It highlights their multifaceted roles in the cell, focuses on the nontrivial roles of quantum mechanics in their membrane and cytoskeletal proteins, and introduces the essential building blocks enabling quantum properties to survive in the warm, wet, and ...
Daniel L. Bilezikian +5 more
wiley +1 more source