Results 231 to 240 of about 30,863 (282)
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Stereoselective synthesis of (+)-hyptolide
Tetrahedron Letters, 2003Abstract The first total synthesis of the naturally occurring lactone (+)-hyptolide is described. Ethyl l -lactate was the chiral starting material. Key steps of this 15-step synthesis were a Brown's asymmetric allylation, a Carreira's asymmetric ethynylation and a ring closing metathesis.
Juan Murga +3 more
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Stereoselective Bromofunctionalization of Alkenes
Chirality, 2013ABSTRACTThe stereoselective bromofunctionalization of alkenes, particularly the enantioselective format, has been a subject of intense research in recent years. The ground‐breaking works are documented in recent reviews. On the other hand, this account will provide an insight into our group's approach in tackling the challenges in enantioselective ...
Chong Kiat, Tan +2 more
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Stereoselective neuroimaging in vivo
European Neuropsychopharmacology, 2007Stereoselectivity is a basic property of many neuronal processes due to the spatial features of molecules involved in neurotransmission. Today, neuroimaging procedures are available for studying stereoselectivity in the living brain. Mirror-image radiotracers are the molecular tools that are used, together with single photon emission tomography (SPECT)
Smith, Donald F., Jakobsen, Steen
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Control of Stereoselectivity in Phosphotriesterase
2004Publisher Summary This chapter describes the control of stereoselectivity in phosphotriesterease (PTE). PTE originally isolated from the soil bacterium Pseudomonas diminuta , catalyzes the hydrolysis of a wide range of organophosphate compounds, including agricultural insecticides and chemical warfare agents. The mechanism of hydrolysis and overall
Suk-Bong, Hong, Frank M, Raushel
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Stereoselective synthesis of microcarpalide
Tetrahedron, 2005Microcarpalide is a strong microfilament disrupting agent. The convergent and stereoselective synthesis of microcarpalide was succeeded via Julia olefination and macrolactonization.
Ken Ishigami +2 more
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Stereoselective Synthesis of (+)-Goniothalesdiol
The Journal of Organic Chemistry, 2006Stereoselective synthesis of antitumor tetrahydrofuran (+)-goniothalesdiol was achieved in high overall yield from (-)-D-tartaric acid. Key features include an FeCl3 mediated THF formation with very high selectivity. Synthesis of natural gonithalesdiol and its analogue 2,5-bis-epi-goniothalesdiol was achieved from a common intermediate.
Prasad, Kavirayani R +1 more
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A Stereoselective Synthesis of Lentiginosine
The Journal of Organic Chemistry, 2016A concise stereoselective synthesis of (-)-lentiginosine, an iminosugar endowed with an interesting proapoptotic activity, has been accomplished using an enantiopure pyrroline N-oxide building block derived from d-tartaric acid. Key steps are a totally diastereoselective nucleophilic addition to the cyclic nitrone followed by a combination of two ...
CORDERO, FRANCA MARIA +2 more
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Stereoselective pharmacokinetics of perhexiline
Xenobiotica, 1986Blood plasma and urine excretion pharmacokinetics of the (+) and (-) enantiomers of perhexiline have been determined in oral single-dose studies in eight human volunteers, and compared with the pharmacokinetics of the racemate drug in the same subjects. The (-) enantiomer is more rapidly metabolized and eliminated, and is stereoselectively hydroxylated
B J, Gould, A G, Amoah, D V, Parke
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Stereoselective Synthesis of (+)-Boronolide
The Journal of Organic Chemistry, 2002The delta-lactone boronolide (+)-1, a pharmacologically active, naturally occurring product, has been synthesized in enantiopure form with L-erythrulose as the chiral starting material. The key steps of the synthesis were a highly stereoselective aldol-reduction one-pot sequence, an indium-mediated diastereoselective aldehyde allylation, and a ring ...
Miguel, Carda +3 more
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Stereoselectivity in drug metabolism
Expert Opinion on Drug Metabolism & Toxicology, 2007Many chiral drugs are used as their racemic mixtures in clinical practice. Two enantiomers of a chiral drug generally differ in pharmacodynamic and/or pharmacokinetic properties as a consequence of the stereoselective interaction with optically active biological macromolecules.
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