Results 241 to 250 of about 27,319 (289)
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Stereoselective neuroimaging in vivo
European Neuropsychopharmacology, 2007Stereoselectivity is a basic property of many neuronal processes due to the spatial features of molecules involved in neurotransmission. Today, neuroimaging procedures are available for studying stereoselectivity in the living brain. Mirror-image radiotracers are the molecular tools that are used, together with single photon emission tomography (SPECT)
Smith, Donald F., Jakobsen, Steen
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A Stereoselective Synthesis of Lentiginosine
The Journal of Organic Chemistry, 2016A concise stereoselective synthesis of (-)-lentiginosine, an iminosugar endowed with an interesting proapoptotic activity, has been accomplished using an enantiopure pyrroline N-oxide building block derived from d-tartaric acid. Key steps are a totally diastereoselective nucleophilic addition to the cyclic nitrone followed by a combination of two ...
CORDERO, FRANCA MARIA +2 more
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Stereoselective synthesis of (+)-boronolide
Tetrahedron Letters, 2005Abstract An efficient enantio- and stereocontrolled total synthesis of (+)-boronolide from valeraldehyde is described. The key steps include a Sharpless asymmetric dihydroxylation, a chelation controlled Grignard reaction followed by Sharpless asymmetric epoxidation and a ring closing metathesis.
S. Vasudeva Naidu +2 more
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Stereoselective synthesis of microcarpalide
Tetrahedron, 2005Microcarpalide is a strong microfilament disrupting agent. The convergent and stereoselective synthesis of microcarpalide was succeeded via Julia olefination and macrolactonization.
Ken Ishigami +2 more
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Stereoselective Synthesis of (+)-Goniothalesdiol
The Journal of Organic Chemistry, 2006Stereoselective synthesis of antitumor tetrahydrofuran (+)-goniothalesdiol was achieved in high overall yield from (-)-D-tartaric acid. Key features include an FeCl3 mediated THF formation with very high selectivity. Synthesis of natural gonithalesdiol and its analogue 2,5-bis-epi-goniothalesdiol was achieved from a common intermediate.
Prasad, Kavirayani R +1 more
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Stereoselective Electrophilic Cyclization
The Chemical Record, 2015AbstractElectrophilic cyclizations of unactivated alkenes play highly important roles in the synthesis of useful building blocks. This account describes our contributions to the rational design of monofunctionalized chiral Lewis base catalysts for enantioselective iodo‐ and protocyclizations.
Akira, Sakakura, Kazuaki, Ishihara
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Control of Stereoselectivity in Phosphotriesterase
2004Publisher Summary This chapter describes the control of stereoselectivity in phosphotriesterease (PTE). PTE originally isolated from the soil bacterium Pseudomonas diminuta , catalyzes the hydrolysis of a wide range of organophosphate compounds, including agricultural insecticides and chemical warfare agents. The mechanism of hydrolysis and overall
Suk-Bong, Hong, Frank M, Raushel
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On the stereoselective aminoacylation of RNA
Advances in Space Research, 1984Aminoacylation of the "internal" 2'hydroxyl groups of poly(A) with the imidazolide of racemic DL-leucine resulted in the formation of an enantiomeric excess of the D-ester, whereas aminoacylation with the imidazolide of racemic N-3,5-dinitrobenzoyl-DL-leucine gave an enantiomeric excess of the L-ester.
D A, Usher, M C, Needels
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Stereoselective pharmacokinetics of perhexiline
Xenobiotica, 1986Blood plasma and urine excretion pharmacokinetics of the (+) and (-) enantiomers of perhexiline have been determined in oral single-dose studies in eight human volunteers, and compared with the pharmacokinetics of the racemate drug in the same subjects. The (-) enantiomer is more rapidly metabolized and eliminated, and is stereoselectively hydroxylated
B J, Gould, A G, Amoah, D V, Parke
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Stereoselective synthesis of (−)-jimenezin
Tetrahedron Letters, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Cheol Hee Hwang +4 more
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