Results 131 to 140 of about 9,285,009 (287)

Single Extracellular Vesicle Profiling to Define Brain Specific Traumatic Brain Injury Induced Neuro‐Inflammation

open access: yesSmall Methods, EarlyView.
A highly innovative and implementable diagnostic tool for profiling microenvironmental perturbations in TBI patients by analyzing sEVs derived from glial cells circulating in the blood. This device provides a window into the injured brain and identifies neuroinflammatory signals, potentially serving as a platform for detecting highly specific brain ...
Zhen Zhang   +10 more
wiley   +1 more source

Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice

open access: yesAging Cell, EarlyView.
Senolytic therapy restores neurovascular function, blood–brain barrier integrity, and cognitive performance in aged mice by targeting endothelial senescence. Findings highlight that brain microvascular endothelial cells are highly vulnerable to aging‐induced senescence, and early intervention in middle age may be the most effective strategy to prevent ...
Boglarka Csik   +20 more
wiley   +1 more source

Ultrassom focalizado: nova arma terapêutica na cirurgia estereotáxica Focused ultrasound: a new weapon for stereotaxic surgery

open access: yesArquivos de Neuro-Psiquiatria, 1967
O autor faz um apanhado das teorias fundamentais do ultrassom focalizado e seu uso em cirurgia estereotáxica cerebral. É feita análise comparativa entre as vantagens do ultrassom frente às demais técnicas de lesão estereotáxica e são considerados os ...
Raul Marino Jr.
doaj  

Human and Mouse Alzheimer's Seeds Differentially Affect Amyloid Deposition and Microglia‐Dependent Plaque Response in Aged Mice

open access: yesAging Cell, EarlyView.
This study shows that human and mouse brains contain a different pool of strains that differentially affect the formation of Aβ and tau aggregates. Moreover, the murine seeds trigger an unresponsiveness microglial state, which causes the loss of plaque microglial coverage and affects the formation of amyloid plaques, leading to more severe neuritic ...
Juana Andreo‐Lopez   +20 more
wiley   +1 more source

MRI guided stereotactic ventrointermediate thalamotomy for writer's cramp: two cases report and literature review

open access: yesChinese Journal of Contemporary Neurology and Neurosurgery, 2015
Objective To explore the methods and curative effect of stereotactic surgery for treating writer's cramp (WC). Methods and Results Two patients with writer's cramp (tremor type) underwent MRI guided stereotactic ventrointermediate (Vim) thalamotomy on
Chao-shi NIU   +4 more
doaj  

The Subcortical Atlas of the Rhesus Macaque (SARM) for neuroimaging

open access: yesNeuroImage, 2021
Digitized neuroanatomical atlases that can be overlaid onto functional data are crucial for localizing brain structures and analyzing functional networks identified by neuroimaging techniques.
Renée Hartig   +7 more
doaj  

Evaluation of directional vacuum-assisted breast biopsy: Report for the National Breast Cancer Centre final report, CHERE Project Report No 21 [PDF]

open access: yes
This project was commissioned by the National Breast Cancer Centre (NBCC). The objectives of the project, as set out in the call for expressions of interest, were to determine: 1.
Lorraine Ivancic, Marion Haas
core  

Accumulation of GSK‐3β in Interneurons Impairs Adult Hippocampal Neurogenesis by Inhibiting GABAergic Transmission

open access: yesAging Cell, EarlyView.
Overexpression of GSK‐3β in DG GABAergic neurons impairs neurogenesis by reducing GABA release, which can be reversed by enhancing GABAergic transmission. ABSTRACT The activation of glycogen synthase kinase 3β (GSK‐3β) and the deterioration of spatial memory represent prominent pathological and clinical manifestations of Alzheimer's disease (AD ...
Fei Liu   +11 more
wiley   +1 more source

Age‐Related Complement C3 Drives Memory Impairments and Associated Neuropathologies in a Mouse Model

open access: yesAging Cell, EarlyView.
Age‐related complement C3 elevation induces memory impairments and neuropathology by dysregulating astrocytic insulin signaling and triggering mitochondrial dysfunction. Critically, antibody blockade of C3 in mouse brain tissue effectively reversed learning and memory deficits in mice, demonstrating that targeting C3 is a promising therapeutic strategy.
Miaomiao Du   +10 more
wiley   +1 more source

A low-cost technique to cryo-protect and freeze rodent brains, precisely aligned to stereotaxic coordinates for whole-brain cryosectioning [PDF]

open access: green, 2013
Vadim Pinskiy   +5 more
openalex   +1 more source

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