Results 31 to 40 of about 133,959 (307)

Electronic and Steric Effects on Oxygen Reactivities of NiFeSe Complexes Related to O₂-Damaged [NiFeSe]-Hydrogenases’ Active Site

Inorganics
Hydrogen has the potential to serve as a new energy resource, reducing greenhouse gas emissions that contribute to climate change. Natural hydrogenases exhibit impressive catalytic abilities for hydrogen production, but they often lack oxygen tolerance ...
Yuchen Qiao, Enting Xu, Yameng Hao, Xuemei Yang, Ming Ni   +4 more
doaj   +1 more source

N-Glycans Mediate the Ebola Virus-GP1 Shielding of Ligands to Immune Receptors and Immune Evasion

Frontiers in Cellular and Infection Microbiology, 2020
The Ebola Virus (EBOV) glycoprotein (GP) sterically shields cell-membrane ligands to immune receptors such as human leukocyte antigen class-1 (HLA-I) and MHC class I polypeptide-related sequence A (MICA), thus mediating immunity evasion. It was suggested
Muhammed Iraqi, Avishay Edri, Yariv Greenshpan, Kiran Kundu, Kiran Kundu, Priyanka Bolel, Avishag Cahana, Aner Ottolenghi, Roi Gazit, Leslie Lobel, Alex Braiman, Angel Porgador, Angel Porgador   +12 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Solid State Structure and Solution Thermodynamics of Three-Centered Hydrogen Bonds (O∙∙∙H∙∙∙O) Using N-(2-Benzoyl-phenyl) Oxalyl Derivatives as Model Compounds

Molecules, 2014
Intramolecular hydrogen bond (HB) formation was analyzed in the model compounds N-(2-benzoylphenyl)acetamide, N-(2-benzoylphenyl)oxalamate and N1,N2-bis(2-benzoylphenyl)oxalamide.
Carlos Z. Gómez-Castro, Itzia I. Padilla-Martínez, Efrén V. García-Báez, José L. Castrejón-Flores, Ana L. Peraza-Campos, Francisco J. Martínez-Martínez   +5 more
doaj   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Study on ethylene/1-hexene copolymerization catalyzed by α-diimine nickel catalysts with different ligands

Magnetic Resonance Letters, 2021
The structure of polyolefin has an important influence on its performance and application. Ethylene/1-hexene copolymerization is one of the important ways to control the structure of the polyolefin.
Yusheng Xing, Haojie Yu, Li Wang, Nan Wang, Lei Zhu, Ruixue Liang, Md Alim Uddin   +6 more
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Steric Effects of Alcohols on the [Mn₄O₄] Cubane-Type Structures

Crystals
[M4O4] (M = 3d transition metal) represents an interesting class of compounds featuring cubane-type molecular structures, and particularly, [Mn4O4] cubanes or their derivatives attract much attention by virtue of their potential applications as single ...
Yan He, Zheng Zhou, Haixiang Han
doaj   +1 more source

Stabilization of α-ZrP ceramic nanosheets adsorbing quaternary ammonium ions in organic solvents and their application as a stable solid support for lipase catalyzing stereospecific synthetic reactions

Journal of Asian Ceramic Societies, 2022
Herein, the effect of immobilizing lipase onto layered α-zirconium phosphate ceramic nanosheets (α-ZrP NS) on the enzymatic transesterification of allylic alcohols was investigated in organic solvents. α-ZrP NS modified with quaternary ammonium ions show
Akane Yamada, Gen Onodera, Masanari Kimura, Kai Kamada   +3 more
doaj   +1 more source

The rapidly growing landscape of RAS inhibitors: from selective allele blockade to broad inhibition strategies

Molecular Oncology, EarlyView.
RAS‐targeted therapies have become a clinical reality. Although promising results in patients have been achieved, there are still challenges ahead such as coping with drug resistance. Here we summarize selected RAS inhibitors targeting either individual KRAS mutant isoforms (KRASG12C, KRASG12D, KRASG12V) or exhibiting a wider inhibitory spectrum ...
Matthias Drosten, Mariano Barbacid
wiley   +1 more source