Results 51 to 60 of about 269,366 (337)
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Russian Journal of Earth Sciences, 2020 Five data sets were used to estimate steric level fluctuations in the North Atlantic for 2003-2015. We compare estimates made by a combination of altimetry and GRACE gravity data (ALT-GRV) with assessments obtained from vertical density profiles derived ...
Koldunov Aleksey +3 more
doaj +1 more source
Al-Kitab Journal for Pure Sciences, 2023 Alkaline hydrolysis rates coefficients for the series of methyl 3-(7-substituted-1-naphthyl) propynoate was calculated in 70%v/v dimethylsulphoxide-water at various temperatures (25,30,40, and 50̊ C).
Khalaf D. F. Ghadir +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
An NMR Study on How Steric Effects Affect Synergistic Effects in Surfactant Mixtures
Chinese Journal of Magnetic Resonance, 2018 NMR spectra of aqueous solutions of cetyltrimethylammonium bromide (CTAB)/triton X-100 (TX-100), sodium dodecyl sulfate (SDS)/TX-100 and CTAB/TX-100/SDS surfactant mixtures were acquired.
CHEN Xiao-ying +4 more
doaj +1 more source
Active Matter Ratchets with an External Drift
, 2013 When active matter particles such as swimming bacteria are placed in an asymmetric array of funnels, it has been shown that a ratchet effect can occur even in the absence of an external drive. Here we examine active ratchets for two dimensional arrays of
Reichhardt, C., Reichhardt, C. J. Olson
core +1 more source
Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer +14 more
wiley +1 more source
From the double-stranded helix to the chiral nematic phase of B-DNA: a molecular model
, 2004 B-DNA solutions of suitable concentration form left-handed chiral nematic phases (cholesterics). Such phases have also been observed in solutions of other stiff or semiflexible chiral polymers; magnitude and handedness of the cholesteric pitch are ...
Ferrarini, A., Tombolato, F.
core +1 more source
Analysis of the conformational profiles of fenamates shows route towards novel, higher accuracy, force-fields for pharmaceuticals [PDF]
, 2015 In traditional molecular mechanics force fields, intramolecular non-bonded interactions are modelled as intermolecular interactions, and the form of the torsion potential is based on the conformational profiles of small organic molecules.
Galek, P, Price, SL, Uzoh, OG
core +1 more source
Advanced Engineering Materials, EarlyView.The release of foulers from protective marine coatings is determined by several interrelated material properties, including the strength of Young's modulus, the flexibility of chain segments, the surface free energy, and the magnitude of hydrodynamic stress.
Johann C. Schaal +2 more
wiley +1 more source