Results 1 to 10 of about 849,950 (196)

Adjuvant Migraine Medications in the Treatment of Sudden Sensorineural Hearing Loss. [PDF]

, 2021
Objectives/hypothesisTo examine the hearing outcomes of patients with sudden sensorineural hearing loss (SSNHL) treated with oral and intratympanic (IT) steroid only or a combination of steroid and migraine treatment.
Abouzari, Mehdi, Chua, Janice T, Djalilian, Hamid R, Goshtasbi, Khodayar, Lin, Harrison W, Saber, Tina, Sarna, Brooke, Tan, Donald   +7 more
core   +1 more source

Investigating anabolic-androgenic steroid dependence and muscle dysmorphia with network analysis among male weightlifters

BMC Psychiatry, 2023
Background Anabolic-androgenic steroid (AAS) dependence has numerous adverse health consequences, and may be driven in part by body image concerns, primarily muscle dysmorphia. This study aims to further understand and identify potential clinical targets
Morgan Scarth, Lars T. Westlye, Ingrid A. Havnes, Astrid Bjørnebekk   +3 more
doaj   +1 more source

17β-Estradiol-Induced Conformational Changes of Human Microsomal Triglyceride Transfer Protein: A Computational Molecular Modelling Study

Cells, 2021
Human microsomal triglyceride transfer protein (hMTP) plays an essential role in the assembly of apoB-containing lipoproteins, and has become an important drug target for the treatment of several disease states, such as abetalipoproteinemia, fat ...
Yong-Xiao Yang, Peng Li, Pan Wang, Bao-Ting Zhu   +3 more
doaj   +1 more source

Attenuation of amyloid‐β‐induced mitochondrial dysfunction by active components of anthocyanins in HT22 neuronal cells

MedComm, 2023
Alzheimer's disease (AD) is a common form of neurodegenerative disease in the elderly. Amyloid‐β (Aβ)‐associated neurotoxicity is an important component of the neurodegenerative change in AD.
Jing Li, Pan Wang, Ming‐Jie Hou, Bao Ting Zhu   +3 more
doaj   +1 more source

Biochemical mechanism of erastin-induced ferroptotic cell death in neuronal cells

Acta Biochimica et Biophysica Sinica, 2023
Ferroptosis is a new form of nonapoptotic cell death closely associated with glutathione (GSH) peroxidase 4 inhibition and/or GSH depletion, resulting in the accumulation of cellular iron and lipid peroxides.
Hou Ming-Jie, Wang Pan, Zhu Bao Ting
doaj   +1 more source

Health service engagement, side effects and concerns among men with anabolic-androgenic steroid use: a cross-sectional Norwegian study

Substance Abuse Treatment, Prevention, and Policy, 2023
Background Recreational use of anabolic-androgenic steroids (AAS) is a public health concern world-wide associated with a range of physical and psychological side effects. Still, people who use AAS tend to be reluctant to seek treatment.
Hans Christian Bordado Henriksen, Ingrid Amalia Havnes, Marie Lindvik Jørstad, Astrid Bjørnebekk   +3 more
doaj   +1 more source

Synthesis, crystal structure, Hirshfeld surfaces, and thermal, mechanical and dielectrical properties of cholest-5-ene

Journal of Taibah University for Science, 2017
The title compound derived from 3β-chlorocholest-5-ene has been synthesized and characterized successfully. A single crystal X-ray investigation of the compound revealed that the van der Waals interactions play a key role in the formation of the ...
Shamsuzzaman, Hena Khanam, Ashraf Mashrai, Mohd Asif, Abad Ali, Assem Barakat, Yahia N. Mabkhot   +6 more
doaj   +1 more source

Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein

MedComm, 2022
GPR17 is a class A orphan G protein‐coupled receptor (GPCR) expressed in neurons and oligodendrocyte progenitors of the central nervous system (CNS). The signalling of GPR17 occurs through the heterotrimeric Gi, but its activation mechanism is unclear ...
Fang Ye, Thian‐Sze Wong, Geng Chen, Zhiyi Zhang, Binghao Zhang, Shiyi Gan, Wei Gao, Jiancheng Li, Zhangsong Wu, Xin Pan, Yang Du   +10 more
doaj   +1 more source

Computational Modeling Study of the Binding of Aging and Non-Aging Inhibitors with Neuropathy Target Esterase

Molecules, 2023
Neuropathy target esterase (NTE) is a serine hydrolase with phospholipase B activity, which is involved in maintaining the homeostasis of phospholipids. It can be inhibited by aging inhibitors such as some organophosphorus (OP) compounds, which leads to ...
Wenxiong Wu, Pan Wang
doaj   +1 more source

Computational exploration of copper catalyzed vinylogous aerobic oxidation of unsaturated compounds

Scientific Reports, 2021
Selective oxidation is one of the most important and challenging transformations in both academic research and chemical industry. Recently, a highly selective and efficient way to synthesize biologically active γ-hydroxy-α,β-unsaturated molecules from Cu-
Ting Wang, Yu Zhou, Yao Xu, Gui-Juan Cheng   +3 more
doaj   +1 more source