Results 1 to 10 of about 482,487 (316)
Philosophical Transactions of the Royal Society B: Biological Sciences, 2021 At the birth of supergenes, the genomic landscape is dramatically re-organized leading to pronounced differences in phenotypes and increased intrasexual diversity. Two of the best-studied supergenes in vertebrates are arguably the inversion polymorphisms on chromosomes 2 and 11 in the white-throated sparrow ( Zonotrichia ...
Küpper, Clemens, Maney, Donna
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BMC Psychiatry, 2023 Background Anabolic-androgenic steroid (AAS) dependence has numerous adverse health consequences, and may be driven in part by body image concerns, primarily muscle dysmorphia. This study aims to further understand and identify potential clinical targets
Morgan Scarth +3 more
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MedComm, 2023 Alzheimer's disease (AD) is a common form of neurodegenerative disease in the elderly. Amyloid‐β (Aβ)‐associated neurotoxicity is an important component of the neurodegenerative change in AD.
Jing Li +3 more
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Cells, 2021 Human microsomal triglyceride transfer protein (hMTP) plays an essential role in the assembly of apoB-containing lipoproteins, and has become an important drug target for the treatment of several disease states, such as abetalipoproteinemia, fat ...
Yong-Xiao Yang +3 more
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Biochemical mechanism of erastin-induced ferroptotic cell death in neuronal cells
Acta Biochimica et Biophysica Sinica, 2023 Ferroptosis is a new form of nonapoptotic cell death closely associated with glutathione (GSH) peroxidase 4 inhibition and/or GSH depletion, resulting in the accumulation of cellular iron and lipid peroxides.
Hou Ming-Jie, Wang Pan, Zhu Bao Ting
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Indian Journal of Endocrinology and Metabolism, 2022 Steroid stewardship is the systematic effort to prescribe and monitor glucocorticoids in a rational manner, while balancing benefit and potential risk, in patients who require this therapy. Steroid stewardship includes pre-prescription screening, rational prescription, medical care during corticosteroid use, and appropriate monitoring after ...
Sanjay Kalra, Ashok Kumar, Rakesh Sahay
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Substance Abuse Treatment, Prevention, and Policy, 2023 Background Recreational use of anabolic-androgenic steroids (AAS) is a public health concern world-wide associated with a range of physical and psychological side effects. Still, people who use AAS tend to be reluctant to seek treatment.
Hans Christian Bordado Henriksen +3 more
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Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein
MedComm, 2022 GPR17 is a class A orphan G protein‐coupled receptor (GPCR) expressed in neurons and oligodendrocyte progenitors of the central nervous system (CNS). The signalling of GPR17 occurs through the heterotrimeric Gi, but its activation mechanism is unclear ...
Fang Ye +10 more
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Molecules, 2023 Neuropathy target esterase (NTE) is a serine hydrolase with phospholipase B activity, which is involved in maintaining the homeostasis of phospholipids. It can be inhibited by aging inhibitors such as some organophosphorus (OP) compounds, which leads to ...
Wenxiong Wu, Pan Wang
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Journal of Taibah University for Science, 2017 The title compound derived from 3β-chlorocholest-5-ene has been synthesized and characterized successfully. A single crystal X-ray investigation of the compound revealed that the van der Waals interactions play a key role in the formation of the ...
Shamsuzzaman +6 more
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