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Four enzymes control natural variation in the steroid core ofErysimumcardenolides

Younkin GC, Alani ML, Züst T, Jander G.
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Molecular Cloning of Steroid Hydroxylases

Endocrine Research, 1984
Recombinant plasmids specific for bovine adrenocortical cytochromes P-450scc and P-45011 beta have been identified and characterized. Using these cDNA inserts as probes, it is found that tissue specificity of gene expression for these two proteins is as expected. Cytochrome P-450scc mRNA is found in adrenocortical and corpus luteum RNA while cytochrome
M E, John, E R, Simpson, V, Boggaram, M R, Waterman   +3 more
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Steroid Hydroxylases

2017
Steroid hormones play an important role in the survival of the individual and of species. This is realized by the regulation of salt and sugar homeostasis by mineralocorticosteroids and glucocorticosteroids and of reproductive processes by sex hormones.
Hofland, J., de Jong, F. H.
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Mutations in Steroid 21-Hydroxylase (CYP21)

Human Mutation, 1994
The inherited inability to synthesize cortisol is termed congenital adrenal hyperplasia. More than 90% of cases are caused by 21-hydroxylase deficiency. This syndrome is characterized by signs of androgen excess and often mineralocorticoid deficiency. Steroid 21-hydroxylase (P450c21) is a microsomal enzyme expressed in the adrenal gland that catalyzes ...
P C, White, M T, Tusie-Luna, M I, New, P W, Speiser   +3 more
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Steroid 21-Hydroxylase Deficiency in Mice*

Endocrinology, 1988
The enzyme steroid 21-hydroxylase (21-OHase) plays a key role in adrenal steroidogenesis. Defects in this enzyme are responsible for one of the most common inborn errors of metabolism in humans. Duplicated genes for the enzyme are located in the class III region of the major histocompatibility complex (MHC), HLA.
H, Gotoh, T, Sagai, J, Hata, T, Shiroishi, K, Moriwaki   +4 more
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Enzyme-activated inhibitors of steroidal hydroxylases

The Journal of Steroid Biochemistry and Molecular Biology, 1995
Cytochrome P450 monooxygenases (CYP450) of the steroid biosynthetic pathways are highly substrate specific in comparison to the variable specificities of hepatic CYP450 enzymes. Both groups of enzymes catalyze the reductive cleavage of molecular oxygen with transfer of oxygen to the substrate to form hydroxylated derivatives.
J O, Johnston, C L, Wright, G W, Holbert
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Role of microsomal steroid hydroxylases in Δ7-steroid biosynthesis

Biochemistry (Moscow), 2013
CYP17 (steroid 17α-hydroxylase/17,20-lyase) is a key enzyme in steroid hormone biosynthesis. It catalyzes two independent reactions at the same active center and has a unique ability to differentiate Δ(4)-steroids and Δ(5)-steroids in the 17,20-lyase reaction.
T A, Sushko, A A, Gilep, A V, Yantsevich, S A, Usanov   +3 more
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Molecular Cloning of Steroid 21-Hydroxylase

Endocrine Research, 1984
Congenital adrenal hyperplasia due to 21-hydroxylase (21-OH) deficiency is HLA-linked. The haplotype HLA-(A3);Bw47;DR7 is strongly associated with 21-OH deficiency and always carries a null allele at the complement C4A (Rodgers) locus. It seemed likely that this haplotype carries a deletion encompassing both the C4A and 21-OH loci. We hypothesized that
P C, White, B, Dupont, M I, New
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Disorders of Steroid 11β-Hydroxylase Isozymes*

Endocrine Reviews, 1994
The most active corticosteroids are 11 beta-hydroxylated. Humans have two isozymes with 11 beta-hydroxylase activity that are respectively required for cortisol and aldosterone synthesis. CYP11B1 (11 beta-hydroxylase) is expressed at high levels and is regulated by ACTH, whereas CYP11B2 (aldosterone synthase) is normally expressed at low levels and is ...
P C, White, K M, Curnow, L, Pascoe
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