Results 141 to 150 of about 509,948 (192)
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An Inhibitor of Adrenal Steroid 11β-Hydroxylase
Nature, 1964Trans-1,4-bis (2-chlorobenzylaminomethyl) cyclohexane dihydrochloride (‘AY–9944’)1 has been shown to represent a novel class of cholesterol biosynthesis inhibitors which act by interfering with the enzymatic conversion of 7-dehydrocholesterol to cholesterol2,3. In laboratory animals, ‘AY–9944’ significantly depressed serum sterol-levels4.
D. Dvornik +3 more
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Identification of multiple steroid hydroxylases in Daphnia magna and their modulation by xenobiotics
, 1994Steroid hydroxylase activities were characterized in Daphnia magna and evaluated for potential use as biomarkers of xenobiotic exposure. Microsomes prepared from Daphma magna generated a single NADPH-dependent metabolite of [14C]testosterone.
W. S. Baldwin, G. LeBlanc
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Steroid 11β-Hydroxylase Deficiency [PDF]
, 2001 Inherited defects in cortisol biosynthesis are collectively termed congenital adrenal hyperplasia [reviewed in (1)]. Steroid 21-hydroxylase deficiency is, by far, the most common of these defects; it is reviewed elsewhere in this volume. This chapter reviews a related disease, steroid 11β-hydroxylase deficiency [reviewed in greater detail in (2)].
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Ca(2+)-regulated expression of steroid hydroxylases in H295R human adrenocortical cells.
Endocrinology, 1995Although changes in the expression of key steroidogenic enzymes such as cytochrome P450 cholesterol side-chain cleavage, 17 alpha-hydroxylase (P450c17), aldosterone synthase, and 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) in the human adrenal ...
I. Bird, J. Mathis, J. Mason, W. Rainey
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Disorders of steroid 11β-hydroxylase isozymes
Trends in Endocrinology & Metabolism, 1992Steroid 11 beta-hydroxylase activity in the adrenal cortex is required for the synthesis of the major glucocorticoids and mineralocorticoids, but different isozymes mediate this conversion in the zona fasciculata, where cortisol is produced, and the zona glomerulosa, the site of aldosterone synthesis.
Perrin C. White, Leigh Pascoe
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Extraadrenal Steroid 21-Hydroxylase Activity in a Woman with Congenital Adrenal Hyperplasia due to Steroid 21-Hydroxylase Deficiency* [PDF]
The Journal of Clinical Endocrinology & Metabolism, 1983 The 21-hydroxylation of plasma progesterone (P) has been demonstrated in pregnant, nonpregnant, and adrenalectomized women and in men. The fractional conversion of plasma progesterone to deoxycorticosterone (DOC), [rho]P-DOC BU, among those subjects was 0.009 +/- 0.001 (mean +/- SEM, n = 32).
R. J. Worley +4 more
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Disorders of Steroid 17α-Hydroxylase Deficiency
Endocrinology and Metabolism Clinics of North America, 1994The human P450c17 alpha gene (CYP17) is a single copy gene located in chromosome 10, consisting of 8 exons and 7 introns. 17 alpha-Hydroxylase/17,20-lyase deficiency is one of two hypertensive forms of congenital adrenal hyperplasia and is inherited as an autosomal recessive trait; although rare, it probably exists with twice the frequency of the 11 ...
Claudio E. Kater, Edward G. Biglieri
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The presence of 6β-steroid hydroxylase in human cornea
Journal of Steroid Biochemistry, 1976Abstract Human cornea were excised at the time of surgical procedure from patients undergoing radical surgery. Three separate incubations were performed in Eagle's minimum essential medium with [4- 14 C]-progesterone as precursor for five days. From the initial radioactivity, 6.9% was biotransformed to 6β-hydroxy-4-pregnene-3,20-dione.
Alfredo J. Gallegos +2 more
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Genetics of steroid 21-hydroxylase deficiency
Trends in Genetics, 1985Abstract Classical and non-classical adrenal hyperplasia due to steroid 21-hydroxylase deficiency (210HD) are HLA-linked, autosomal recessive disorders characterized by a variable degree of hyperandrogenism and cortisol deficiency. Direct screening of newborns has placed the incidence of the classical disease at 1 : 5000 to 1 : 15 000, whereas the ...
Maria I. New, Phyllis W. Speiser
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Control of gene expression of adrenal steroid hydroxylases and related enzymes.
Endocrine Research, 1986Utilization of cDNA probes specific for various components of the bovine adrenocortical steroidogenic pathway have led to the conclusion that there are three levels of regulation of steroid hydroxylase gene expression.
M. Waterman +5 more
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