Results 11 to 20 of about 43,028 (255)
Perturbing local steroidogenesis to improve breast cancer immunity [PDF]
Nature CommunicationsBreast cancer, particularly triple-negative breast cancer (TNBC), evades the body’s immune defences, in part by cultivating an immunosuppressive tumour microenvironment.
Qiuchen Zhao +12 more
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Translocator protein and steroidogenesis [PDF]
Biochemical Journal, 2018 Two interesting papers by Barren et al. and Owen et al. have been very recently published in Biochemical Journal, reporting the role of translocator protein (TSPO) in steroidogenesis. The involvement of TSPO in the steroid biosynthesis has been suggested by 30 years of researches, using biochemical, pharmacological and genetic experimental approaches ...
Costa, Barbara +2 more
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Chemical Suppression of Steroidogenesis [PDF]
Environmental Health Perspectives, 1981 A large number of chemicals are known to interfere with steroidogenesis in the adrenal cortex and other tissues. Many xenobiotics inhibit steroid hormone production as a result of interactions with cytochrome P-450-containing hydroxylases in adrenal mitochondria or microsomes.
Colby, H D
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Cortisol synthesis by primary human keratinocytes [PDF]
, 2009 PhDCortisol analogues have been used to treat skin disorders, such as psoriasis and atopic dermatitis, for over 50 years but the ability of normal human keratinocytes to synthesise cortisol has not been reported.
Hannen, Rosalind Francesca
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Defects of steroidogenesis [PDF]
Journal of Endocrinological Investigation, 2010 In the biosynthesis of steroid hormones the neutral lipid cholesterol, a normal constituent of lipid bilayers is transformed via a series of hydroxylation, oxidation, and reduction steps into a vast array of biologically active compounds: mineralocorticoids, glucocorticoids, and sex hormones.
BIASON LAUBER A +3 more
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Intestinal steroidogenesis [PDF]
Steroids, 2015 Steroids are fundamental hormones that control a wide variety of physiological processes such as metabolism, immune functions, and sexual characteristics. Historically, steroid synthesis was considered a function restricted to the adrenals and the gonads.
Bouguen, Guillaume +4 more
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Toxics, 2022 Copper is essential for several cellular processes and is an important catalytic factor for many proteins. However, excess copper can provoke oxidative stress and reproductive toxicity.
Wedad S. Sarawi +9 more
doaj +1 more source
"Ex vivo" and "in vivo" studies to assess chemical effects on steroidogenesis in fish: development and application of methods [PDF]
, 2011 The aquatic environment receives many chemical substances of natural or anthropogenic origin, which can influence the endocrine functions and health of wildlife.
a Marca Pereira, Luz Maria
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BMI1 Drives Steroidogenesis Through Epigenetically Repressing the p38 MAPK Pathway
Frontiers in Cell and Developmental Biology, 2021 Testosterone biosynthesis progressively decreases in aging males primarily as a result of functional changes to Leydig cells. Despite this, the mechanisms underlying steroidogenesis remain largely unclear.
Jun Yu +13 more
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Optic Atrophy 1- Dependent Mitochondrial Remodeling Controls Steroidogenesis in Trophoblasts [PDF]
, 2012 During human pregnancy, placental trophoblasts differentiate and syncytialize into syncytiotrophoblasts that sustain progesterone production [1]. This process is accompanied by mitochondrial fragmentation and cristae remodeling [2], two facets of ...
Rafelski, S. M. +2 more
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