Results 41 to 50 of about 43,028 (255)

Concerns with Male Infertility Induced by Exposure to Titanium Nanoparticles and the Supporting Impact of Pelargonium graveolens Essential Oil: Morphometric Records in Male-Wistar Rats

Life, 2022
Background: Due to the increased use of titanium dioxide nanoparticles (TiO2 NPs), the risks of their reprotoxic effect arise. This study anticipated examining the potential protective effects of GEO (geranium essential oil) components screened via GC/MS
Ahmed Abdou Said, Yasmin Nasr, Azza A. A. Galal, Ahmed E. Abdelhamid, Haiam A. Mohamed, Mohamed M. M. Metwally, Mahmoud A. Said, Mohamed A. Nassan, Naief Dahran, Amany Abdel-Rahman Mohamed   +9 more
doaj   +1 more source

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source

Metabolomic fingerprints of clustered preterm and term neonates – a pilot study

Frontiers in Endocrinology
IntroductionAdrenal steroidogenesis plays a pivotal role in neonatal adaptation, and advanced steroid profiling offers novel insights into disease risks and personalized management strategies.
Miłosz Lorek, Miłosz Lorek, Teresa Joanna Stradomska, Anna Siejka, Janusz Fuchs, Dominika Januś, Aneta Gawlik-Starzyk   +6 more
doaj   +1 more source

Preclinical and Clinical Research Models of Prostate Cancer: A Brief Overview

Life, 2022
The incidence and mortality from prostate cancer (PCa) are on the rise which poses a major public health concern worldwide. In this narrative review, we have summarized the characteristics of major in vitro and in vivo PCa models including their utility ...
Debasish Basak, Lisney Gregori, Fatema Johora, Subrata Deb   +3 more
doaj   +1 more source

Hedgehog Signaling and Steroidogenesis [PDF]

Annual Review of Physiology, 2015
Since its discovery nearly 30 years ago, the Hedgehog (Hh) signaling pathway has been shown to be pivotal in many developmental and pathophysiological processes in several steroidogenic tissues, including the testis, ovary, adrenal cortex, and placenta.
Isabella, Finco, Christopher R, LaPensee, Kenneth T, Krill, Gary D, Hammer   +3 more
openaire   +2 more sources

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

SIRT1: A Key Player in Male Reproduction

Life, 2022
Reproduction is the way to immortality for an individual, and it is essential to the continuation of the species. Sirtuins are involved in cellular homeostasis, energy metabolism, apoptosis, age-related problems, and sexual reproduction. Sirtuin 1 (SIRT1)
Muhammad Babar Khawar, Abdullah Muhammad Sohail, Wei Li   +2 more
doaj   +1 more source

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

Form of Supplemental Selenium Affects the Expression of mRNA Transcripts Encoding Selenoproteins, and Proteins Regulating Cholesterol Uptake, in the Corpus Luteum of Grazing Beef Cows

Animals, 2022
Selenium (Se)-deficient soils necessitate supplementation of this mineral to the diet of forage-grazing cattle. Functionally, Se is incorporated into selenoproteins, some of which function as important antioxidants.
Sarah N. Carr, Benjamin R. Crites, Joy L. Pate, Camilla H. K. Hughes, James C. Matthews, Phillip J. Bridges   +5 more
doaj   +1 more source

High-Throughput H295R Steroidogenesis Assay Approach to Characterize Effects on Steroidogenesis: Data Associated with Publication

, 2018
Data associated with publication on High-Throughput H295R Steroidogenesis Assay Approach to Characterize Effects on Steroidogenesis.
EPA's National Center for Computational Toxicology (5039467)
core   +1 more source