Molecular Mechanisms of Steroid Hormone Biosynthesis and Action
, 2023 Steroids are essential hormones that regulate biological processes across their lifespan. Steroid hormone production and action must be tightly controlled otherwise there can be detrimental effects on physiological function leading to disease.
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Discovery of autophagy as a universal mechanism for sex steroid synthesis in human ovary and testis
Autophagy Reports, 2023 We recently discovered that lipophagy is a key mechanism to provide free cholesterol required for steroid biosynthesis in human ovary and testis. Pharmacological or genetic inhibition of autophagy by silencing of the autophagy-related (ATG) genes BECN1 ...
Yashar Esmaeilian +6 more
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Toxins, 2023 Deoxynivalenol (DON) is a major mycotoxin present in animal feed and negatively affects growth and reproduction in farm species, including pigs and cattle.
Angelica D. Reyes-Perea +4 more
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Insulin-Like Growth Factor II (IGF-II) Is More Potent Than IGF-I in Stimulating Cortisol Secretion from Cultured Bovine Adrenocortical Cells: Interaction with the IGF-I Receptor and IGF-Binding Proteins [PDF]
, 1995 Although the stimulating effect of insulin-like growth factor I (IGF-I) on adrenal steroidogenesis has been well established, the role of IGF-II in the adult adrenal gland remains unknown.
Weber, Matthias M. +3 more
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Korean Ginseng Berry Extract Enhances the Male Steroidogenesis Enzymes In Vitro and In Vivo
The World Journal of Men's Health, 2023 Purpose: Testosterone hormonal replacement is the most commonly prescribed solution for men with reproductive issues; however, this treatment has various drawbacks.
Hyun Joo Chung +6 more
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The in vitro modulation of steroidogenesis by inflammatory cytokines and insulin in TM3 Leydig cells
Reproductive Biology and Endocrinology, 2018 Background Cytokines and hormones, including insulin, are known to modulate the hypothalamic-pituitary-testes axis and steroidogenesis, both centrally and peripherally.
Kristian Leisegang, Ralf Henkel
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European Journal of Histochemistry, 2022 Pituitary adenylate cyclase-activating polypeptide (PACAP) plays an important role in the steroidogenesis and spermatogenesis in the testis through its receptors PAC1, VPAC1, and VPAC2.
Zeqi Tang +7 more
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LPS-Induced Systemic Inflammation Caused mPOA-FSH/LH Disturbance and Impaired Testicular Function
Frontiers in Endocrinology, 2022 Male reproductive function is key to the continuation of species and is under sophisticated regulation, challenged by various stressors including inflammation. In the lipopolysaccharide (LPS) intraperitoneal injection-induced acute systemic inflammation,
Peilei Shen +16 more
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Monogenic Disorders of Adrenal Steroidogenesis [PDF]
, 2018 Disorders of adrenal steroidogenesis comprise autosomal recessive conditions affecting steroidogenic enzymes of the adrenal cortex. Those are located within the 3 major branches of the steroidogenic machinery involved in the production of ...
Wiebke Arlt +2 more
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AMPK/ULK1 enhances mitophagy and steroidogenesis in duck Granulosa cells under heat exposure
Poultry ScienceMitochondria play crucial roles in energy metabolism and steroidogenesis. Heat stress suppresses steroidogenesis in ovarian granulosa cells (GCs) and impairs poultry reproduction.
Xiaozhi Zhan +8 more
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